Search Results - "IANNONE, Marie"

A prospective investigation into the reasons why insured United States patients drop out of in vitro fertilization treatment by Domar, Alice D., Ph.D, Smith, Kristin, Conboy, Lisa, Sc.D, Iannone, Marie, M.S, Alper, Michael, M.D

“…Objective To determine the primary reason why insured patients drop out of IVF treatment in the United States and to identify methods to decrease such…”
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Multiplexed microsphere-based flow cytometric assays by Kellar, Kathryn L, Iannone, Marie A

“…Flow cytometry has become an indispensable tool for clinical diagnostics and basic research. Although primarily designed for cellular analysis, flow cytometers…”
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Identification and Characterization of a Selective Peroxisome Proliferator-Activated Receptor β/δ (NR1C2) Antagonist by Shearer, Barry G, Steger, David J, Way, James M, Stanley, Thomas B, Lobe, David C, Grillot, Didier A, Iannone, Marie A, Lazar, Mitchell A, Willson, Timothy M, Billin, Andrew N

“…The identification of small molecule ligands for the peroxisome proliferator-activated receptors (PPARs) has been instrumental in elucidating their biological…”
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Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor by Biggadike, Keith, Bledsoe, Randy K, Coe, Diane M, Cooper, Tony W.J, House, David, Iannone, Marie A, Macdonald, Simon J.F, Madauss, Kevin P, McLay, Iain M, Shipley, Tracy J, Taylor, Simon J, Tran, Thuy B, Uings, Iain J, Weller, Victoria, Williams, Shawn P

“…Crystallography and computer modeling have been used to exploit a previously unexplored channel in the glucocorticoid receptor (GR). Highly potent,…”
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The frequency of Treg subsets distinguishes disease activity in ANCA vasculitis by Agosto‐Burgos, Christian, Wu, Eveline Y, Iannone, Marie A, Hu, Yichun, Hogan, Susan L, Henderson, Candace D, Kennedy, Kristin B, Blazek, Lauren, Herrera, Carolina A, Munson, Dominique, Falk, Ronald J, Ciavatta, Dominic J, Free, Meghan E

“…Objectives T regulatory cells (Tregs) are a heterogeneous group of immunoregulatory cells that dampen self‐harming immune responses and prevent the development…”
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Structure-Guided Design of N-Phenyl Tertiary Amines as Transrepression-Selective Liver X Receptor Modulators with Anti-Inflammatory Activity by Chao, Esther Y, Caravella, Justin A, Watson, Mike A, Campobasso, Nino, Ghisletti, Serena, Billin, Andrew N, Galardi, Cristin, Wang, Ping, Laffitte, Bryan A, Iannone, Marie A, Goodwin, Bryan J, Nichols, Jason A, Parks, Derek J, Stewart, Eugene, Wiethe, Robert W, Williams, Shawn P, Smallwood, Angela, Pearce, Kenneth H, Glass, Christopher K, Willson, Timothy M, Zuercher, William J, Collins, Jon L

“…A cocrystal structure of T1317 (3) bound to hLXRβ was utilized in the design of a series of substituted N-phenyl tertiary amines. Profiling in binding and…”
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Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1 by Sanz, Marta, Weideman, Ann Marie K., Ward, Adam R., Clohosey, Matthew L., Garcia-Recio, Susana, Selitsky, Sara R., Mann, Brendan T., Iannone, Marie Anne, Whitworth, Chloe P., Chitrakar, Alisha, Garrido, Carolina, Kirchherr, Jennifer, Coffey, Alisha R., Tsai, Yi- Hsuan, Samir, Shahryar, Xu, Yinyan, Copertino, Dennis, Bosque, Alberto, Jones, Brad R., Parker, Joel S., Hudgens, Michael G., Goonetilleke, Nilu, Soriano-Sarabia, Natalia

“…Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts…”
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Discovery of Novel Quinoline-Based Estrogen Receptor Ligands Using Peptide Interaction Profiling by Hoekstra, William J, Patel, Hari S, Liang, Xi, Blanc, Jean-Baptiste E, Heyer, Dennis O, Willson, Timothy M, Iannone, Marie A, Kadwell, Sue H, Miller, Lisa A, Pearce, Kenneth H, Simmons, Catherine A, Shearin, Jean

“…Traditional approaches to discovery of selective estrogen receptor modulators (SERMs) have relied on ER binding and cell-based estrogen response element-driven…”
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Discovery of novel nuclear receptor modulating ligands: an integral role for peptide interaction profiling by Pearce, Kenneth H., Iannone, Marie A., Simmons, Catherine A., Gray, John G.

“…Nuclear receptors have historically been excellent drug targets, despite being associated with phenomenally complex and multifaceted biological pathways. This…”
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Correlation between in Vitro Peptide Binding Profiles and Cellular Activities for Estrogen Receptor-Modulating Compounds by Iannone, Marie A, Simmons, Catherine A, Kadwell, Sue H, Svoboda, Daniel L, Vanderwall, Dana E, Deng, Su-Jun, Consler, Thomas G, Shearin, Jean, Gray, John G, Pearce, Kenneth H

“…Numerous biochemical and structural studies have shown that the conformation of the estrogen receptor α (ERα) can be influenced by ligand binding. In turn, the…”
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Effect of microsphere binding site density on the apparent affinity of an interaction partner by Iannone, Marie A., Consler, Thomas G.

“…Background: Flow cytometric microsphere‐based binding assays can be used to measure molecular interactions with high sensitivity. We have used multiplexed…”
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Co-crystal structure guided array synthesis of PPARγ inverse agonists by Trump, Ryan P., Cobb, Jeffrey E., Shearer, Barry G., Lambert, Millard H., Nolte, Robert T., Willson, Timothy M., Buckholz, Richard G., Zhao, Sumin M., Leesnitzer, Lisa M., Iannone, Marie A., Pearce, Kenneth H., Billin, Andrew N., Hoekstra, William J.

“…PPARγ-activating thiazolidinediones and carboxylic acids such as farglitazar exert their anti-diabetic effects in part in PPARγ rich adipose. Both pro- and…”
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A microsphere-based assay for multiplexed single nucleotide polymorphism analysis using single base chain extension by Chen, J, Iannone, M A, Li, M S, Taylor, J D, Rivers, P, Nelsen, A J, Slentz-Kesler, K A, Roses, A, Weiner, M P

“…A rapid, high throughput readout for single-nucleotide polymorphism (SNP) analysis was developed employing single base chain extension and cytometric analysis…”
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Characterization of nuclear receptor ligands by multiplexed peptide interactions by Iannone, Marie A

“…This unit describes a method to evaluate the effect that small molecules have on the binding interactions of a nuclear receptor protein with a series of…”
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Unique T cell signatures are associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort by Yount, Kacy, Chen, Chi-Jane, Kollipara, Avinash, Liu, Chuwen, Mokashi, Neha, Zheng, Xiaojing, O'Connell, Catherine, Bagwell, C, Iannone, Marie, Wiesenfeld, Harold, Hillier, Sharon, Stanley, Natalie, Darville, Toni

“…Abstract Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection (STI) in the U.S. despite effective antibiotics. Understanding…”
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Microsphere-based single nucleotide polymorphism genotyping by Iannone, Marie A, Taylor, J David, Chen, Jingwen, Li, May-Sung, Ye, Fei, Weiner, Michael P

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CD4+ T cell memory restoration upon antiretroviral initiation in people living with HIV by Sponaugle, Alexis Thieme, Clutton, Genevieve, Iannone, Marie, Eron, Joseph, Goonetilleke, Nilu

“…Abstract HIV infection causes a rapid loss of CD4+ T cells that is attributed to both direct cytotoxicity of infected CD4+ T cells and bystander loss due to…”
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Abstract 5057: Single cell RNA sequencing reveals altered natural killer-like, effector CD8+ T lymphocytes in smokers by Martos, Suzanne N., Campbell, Michelle R., Iannone, Marie A., Pittman, Gary S., Wan, Ma, Bell, Douglas A.

“…Abstract Tobacco smoke exposure is a risk factor for many human diseases and the global disease burden attributed to smoking remains substantial. In addition…”
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Multidimensional phenotypic immune profiling of Chlamydia trachomatis infected women using mass cytometry platform by Kollipara, Avinash, Iannone, Marie A., Poston, Taylor, Lee, De’Ashia E., O’Connell, Catherine, Zheng, Xiaojing, Hillier, Sharon, Wiesenfeld, Harold, Darville, Toni

“…Abstract Chlamydia trachomatis (CT) is the most frequently reported bacterial sexually transmitted infection in the U.S., with 1 in 20 sexually active young…”
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Optimization of transient gene expression in mammalian cells and potential for scale-up using flow electroporation by Parham, J H, Iannone, M A, Overton, L K, Hutchins, J T

“…The goals of this study were to identify mammalian cell lines which could be efficiently transiently-transfected and scaled-up for protein production. The…”
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