Search Results - "IANCU, Emanuela M"

Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients by Iancu, Emanuela M, Gannon, Philippe O, Laurent, Julien, Gupta, Bhawna, Romero, Pedro, Michielin, Olivier, Romano, Emanuela, Speiser, Daniel E, Rufer, Nathalie

“…Persistent viruses are kept in check by specific lymphocytes. The clonal T cell receptor (TCR) repertoire against Epstein-Barr virus (EBV), once established…”
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Challenges and advantages of cell therapy manufacturing under Good Manufacturing Practices within the hospital setting by Iancu, Emanuela M, Kandalaft, Lana E

“…•Academic cellular GMP facilities are crucial for the advancement of immunotherapy.•Academic cellular immunotherapy Phase I studies have many…”
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Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes by Speiser, Daniel E, Wieckowski, Sébastien, Gupta, Bhawna, Iancu, Emanuela M, Baumgaertner, Petra, Baitsch, Lukas, Michielin, Olivier, Romero, Pedro, Rufer, Nathalie

“…Immune protection from infectious diseases and cancer is mediated by individual T cells of different clonal origin. Their functions are tightly regulated but…”
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Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial by Legat, Amandine, Maby-El Hajjami, Hélène, Baumgaertner, Petra, Cagnon, Laurène, Abed Maillard, Samia, Geldhof, Christine, Iancu, Emanuela M, Lebon, Luc, Guillaume, Philippe, Dojcinovic, Danijel, Michielin, Olivier, Romano, Emanuela, Berthod, Grégoire, Rimoldi, Donata, Triebel, Frédéric, Luescher, Immanuel, Rufer, Nathalie, Speiser, Daniel E

“…Cancer vaccines aim to generate and maintain antitumor immune responses. We designed a phase I/IIa clinical trial to test a vaccine formulation composed of…”
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The proteolytic activity of the paracaspase MALT1 is key in T cell activation by Fasel, Nicolas, Rueda, Daniel, Moser, Roger, Rufer, Nathalie, Rebeaud, Fabien, Tapernoux, Myriam, Guzzardi, Montserrat, Iancu, Emanuela M, Thome, Margot, Gaide, Olivier, Hailfinger, Stephan, Posevitz-Fejfar, Anita

“…The paracaspase MALT1 is pivotal in antigen receptor–mediated lymphocyte activation and lymphomagenesis. MALT1 contains a caspase-like domain, but it is…”
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Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes by Romero, Pedro, Zippelius, Alfred, Kurth, Isabel, Pittet, Mikael J, Touvrey, Cedric, Iancu, Emanuela M, Corthesy, Patricia, Devevre, Estelle, Speiser, Daniel E, Rufer, Nathalie

“…In humans, the pathways of memory and effector T cell differentiation remain poorly defined. We have dissected the functional properties of ex vivo…”
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Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients by Gannon, Philippe O, Baumgaertner, Petra, Huber, Alexandre, Iancu, Emanuela M, Cagnon, Laurène, Abed Maillard, Samia, Maby-El Hajjami, Hélène, Speiser, Daniel E, Rufer, Nathalie

“…Patients with cancer benefit increasingly from T-cell-based therapies, such as adoptive T-cell transfer, checkpoint blockade, or vaccination. We have…”
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Development of an optimized closed and semi-automatic protocol for Good Manufacturing Practice manufacturing of tumor-infiltrating lymphocytes in a hospital environment by Gannon, Philippe O., Harari, Alexandre, Auger, Aymeric, Murgues, Clément, Zangiacomi, Vincent, Rubin, Olivier, Ellefsen Lavoie, Kim, Guillemot, Laurent, Navarro Rodrigo, Blanca, Nguyen-Ngoc, Tu, Rusakiewicz, Sylvie, Rossier, Laetitia, Boudousquié, Caroline, Baumgaertner, Petra, Zimmermann, Stefan, Trueb, Lionel, Iancu, Emanuela M., Sempoux, Christine, Demartines, Nicolas, Coukos, George, Kandalaft, Lana E.

“…Several studies report on Good Manufacturing Process (GMP)-compliant manufacturing protocols for the ex vivo expansion of tumor-infiltrating lymphocytes (TILs)…”
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Clonotype Selection and Composition of Human CD8 T Cells Specific for Persistent Herpes Viruses Varies with Differentiation but Is Stable Over Time by Iancu, Emanuela M, Corthesy, Patricia, Baumgaertner, Petra, Devevre, Estelle, Voelter, Verena, Romero, Pedro, Speiser, Daniel E, Rufer, Nathalie

“…Protection from reactivation of persistent herpes virus infection is mediated by Ag-specific CD8 T cell responses, which are highly regulated by still poorly…”
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Assessing ageing of individual T lymphocytes: Mission impossible? by Iancu, Emanuela M., Speiser, Daniel E., Rufer, Nathalie

“…Effector T lymphocytes are the progeny of a limited number of antigen-specific precursor cells and it has been estimated that clonotypic human T cells may…”
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Simultaneous Coexpression of Memory-related and Effector-related Genes by Individual Human CD8 T Cells Depends on Antigen Specificity and Differentiation by GUPTA, Bhawna, IANCU, Emanuela M, GANNON, Philippe O, WIECKOWSKI, Sébastien, BAITSCH, Lukas, SPEISER, Daniel E, RUFER, Nathalie

“…Phenotypic and functional cell properties are usually analyzed at the level of defined cell populations but not single cells. Yet, large differences between…”
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Profile of a Serial Killer : Cellular and Molecular Approaches to Study Individual Cytotoxic T-Cells following Therapeutic Vaccination by Iancu, Emanuela M., Baumgaertner, Petra, Wieckowski, Sébastien, Speiser, Daniel E., Rufer, Nathalie

“…T-cell vaccination may prevent or treat cancer and infectious diseases, but further progress is required to increase clinical efficacy. Step-by-step…”
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Assessing ageing of individual T lymphocytes : Mission impossible?: Telomere Function by IANCU, Emanuela M, SPEISER, Daniel E, RUFER, Nathalie

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Persistence of EBV Antigen-Specific CD8 T Cell Clonotypes during Homeostatic Immune Reconstitution in Cancer Patients: e78686 by Iancu, Emanuela M, Gannon, Philippe O, Laurent, Julien, Gupta, Bhawna, Romero, Pedro, Michielin, Olivier, Romano, Emanuela, Speiser, Daniel E, Rufer, Nathalie

“…Persistent viruses are kept in check by specific lymphocytes. The clonal T cell receptor (TCR) repertoire against Epstein-Barr virus (EBV), once established…”
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Four Functionally Distinct Populations of Human Effector-Memory CD8 super(+) T Lymphocytes by Romero, Pedro, Zippelius, Alfred, Kurth, Isabel, Pittet, Mikaeel J, Touvrey, Cedric, Iancu, Emanuela M, Corthesy, Patricia, Devevre, Estelle, Speiser, Daniel E, Rufer, Nathalie

“…In humans, the pathways of memory and effector T cell differentiation remain poorly defined. We have dissected the functional properties of ex vivo…”
Get full text