Search Results - "IACOPETTA, B"

The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3 by Miller, T.J., McCoy, M.J., Hemmings, C., Bulsara, M.K., Iacopetta, B., Platell, C.F.

“…Cancer stem-like cells are highly tumourigenic cells that can repopulate entire tumours after apparent successful treatment. Recent evidence suggests they…”
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p53 and disease: when the guardian angel fails by Royds, J A, Iacopetta, B

“…The p53 tumor suppressor gene (TP53) is mutated more often in human cancers than any other gene yet reported. Of importance, it is mutated frequently in the…”
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Sequential expression of putative stem cell markers in gastric carcinogenesis by Wang, T, Ong, C W, Shi, J, Srivastava, S, Yan, B, Cheng, C L, Yong, W P, Chan, S L, Yeoh, K G, Iacopetta, B, Salto-Tellez, M

“…Background: Gastric carcinogenesis has been well documented in the step-wise histopathological model, known as Correa pathway. Several biomarkers including…”
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Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients by MORRIS, M, PLATELL, C, FRITSCHI, L, IACOPETTA, B

“…Two recent North American studies have shown that completion of 5-fluorouracil (5FU)-based adjuvant chemotherapy is a major prognostic factor for the survival…”
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A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil by LACOPETTA, B, GRIEU, F, JOSEPH, B, ELSALEH, H

“…High levels of thymidylate synthase (TS) expression have been associated with poor survival of colorectal cancer (CRC) patients to 5-fluorouracil (5-FU)-based…”
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DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer by KAWAKAMI, K, RUSZKIEWICZ, A, BENNETT, G, MOORE, J, GRIEU, F, WATANABE, G, IACOPETTA, B

“…The CpG-island methylator phenotype (CIMP+) in colorectal cancer (CRC) is characterised by frequent hypermethylation of promoter regions in tumour suppressor…”
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Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands by van Rijnsoever, M, Grieu, F, Elsaleh, H, Joseph, D, Iacopetta, B

“…Background and aims: A subgroup of colorectal cancers (CRC) referred to as the CpG island methylator phenotype (CIMP+) shows simultaneous methylation of…”
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Population-based study of prognostic factors in stage II colonic cancer by Morris, M., Platell, C., de Boer, B., McCaul, K., Iacopetta, B.

“…Background: Adjuvant chemotherapy in stage II colorectal cancer may be considered for patients whose tumours have poor prognostic features. The aim of this…”
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Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study by ANDREYEV, H. J. N, NORMAN, A. R, BERANEK, M, JANDIK, P, BENAMOUZIG, R, JULLIAN, E, LAURENT-PUIG, P, OLSCHWANG, S, MULLER, O, HOFFMANN, I, RABES, H. M, ZIETZ, C, CUNNINGHAM, D, TROUNGOS, C, VALAVANIS, C, YUEN, S. T, HO, J. W. C, CROKE, C. T, O'DONOGHUE, D. P, GIARETTI, W, RAPALLO, A, RUSSO, A, BAZAN, V, OATES, J, TANAKA, M, OMURA, K, AZUMA, T, OHKUSA, T, FUJIMORI, T, ONO, Y, PAULY, M, FABER, C, GLAESENER, R, DE GOEIJ, Afpm, DIX, B. R, ARENDS, J. W, ANDERSEN, S. N, LÖVIG, T, BREIVIK, J, GAUDERNACK, G, CLAUSEN, O. P. F, DE ANGELIS, P, MELING, G. I, ROGNUM, T. O, SMITH, R, LACOPETTA, B. J, GOH, H-S, FONT, A, ROSELL, R, SUN, X. F, ZHANG, H, BENHATTAR, J, LOSI, L, LEE, J. Q, WANG, S. T, YOUNG, J, WALSH, T, WARD, R, HAWKINS, N

“…Researchers worldwide with information about the Kirsten ras (Ki-ras) tumour genotype and outcome of patients with colorectal cancer were invited to provide…”
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Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer by Chua, W, Goldstein, D, Lee, C K, Dhillon, H, Michael, M, Mitchell, P, Clarke, S J, Iacopetta, B

“…Background: To investigate three genetic alterations ( TP53 mutation, Kras mutation and microsatellite instability (MSI)) and three polymorphisms (methylene…”
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Identification of human papillomavirus DNA gene sequences in human breast cancer by KAN, C.-Y, LACOPETTA, B. J, LAWSON, J. S, WHITAKER, N. J

“…Human papilloma viruses (HPVs) are accepted as being carcinogenic in human cervical and anogenital cancers. The suspicion that HPVs may also have a role in…”
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Integrating next-generation sequencing into the diagnostic testing of inherited cancer predisposition by Ku, CS, Cooper, DN, Iacopetta, B, Roukos, DH

“…The clinical application of next‐generation sequencing (NGS) as a diagnostic tool has become increasingly evident. The coupling of NGS technologies with new…”
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A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability by Shannon, B, Gnanasampanthan, S, Beilby, J, Iacopetta, B

“…Background: The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital to methylation reactions. A…”
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Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy by Soong, R., Shah, N., Salto-Tellez, M., Tai, B. C., Soo, R. A., Han, H. C., Ng, S. S., Tan, W. L., Zeps, N., Joseph, D., Diasio, R. B., Iacopetta, B.

“…Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked…”
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The expression of RUNX3 in colorectal cancer is associated with disease stage and patient outcome by Soong, R, Shah, N, Peh, B K, Chong, P Y, Ng, S S, Zeps, N, Joseph, D, Salto-Tellez, M, Iacopetta, B, Ito, Y

“…RUNX3 is believed to have tumour suppressor properties in several cancer types. Inactivation of RUNX3 has been shown to occur by methylation-induced…”
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Objective analysis of cancer stem cell marker expression using immunohistochemistry by Miller, T.J., McCoy, M.J., Hemmings, C., Bulsara, M.K., Iacopetta, B., Platell, C.F.

“…Analysis of immunohistochemical expression is often a subjective and semiquantitative process that can lead to the inconsistent reporting of results. To assess…”
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Meat consumption and cooking practices and the risk of colorectal cancer by Tabatabaei, S M, Fritschi, L, Knuiman, M W, Boyle, T, Iacopetta, B J, Platell, C, Heyworth, J S

“…Background/Objectives: The association between meat consumption and the risk of colorectal cancer (CRC) has been controversial. One of the difficulties in…”
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The −174 G C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype by IACOPETTA, B, GRIEU, F, JOSEPH, D

“…Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position…”
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Can population differences in chemotherapy outcomes be inferred from differences in pharmacogenetic frequencies? by Loh, M, Chua, D, Yao, Y, Soo, R A, Garrett, K, Zeps, N, Platell, C, Minamoto, T, Kawakami, K, Iacopetta, B, Soong, R

“…Inter-ethnic differences in drug handling and frequencies of pharmacogenetic variants are increasingly being characterized. In this study, we systematically…”
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Polymorphisms of the Interleukin-6 Gene Promoter and Abdominal Aortic Aneurysm by Smallwood, L, Allcock, R, van Bockxmeer, F, Warrington, N, Palmer, L.J, Iacopetta, B, Norman, P.E

“…Background Elevated levels of circulating interleukin-6 (IL-6) have been reported in patients with abdominal aortic aneurysms (AAAs). Although this implicates…”
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