Search Results - "I Fichtner"

SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival by Schmid, F, Wang, Q, Huska, M R, Andrade-Navarro, M A, Lemm, M, Fichtner, I, Dahlmann, M, Kobelt, D, Walther, W, Smith, J, Schlag, P M, Stein, U

“…MACC1 (metastasis associated in colon cancer 1) is a prognostic biomarker for tumor progression, metastasis and survival of a variety of solid cancers…”
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Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer by Sack, Ulrike, Walther, Wolfgang, Scudiero, Dominic, Selby, Mike, Kobelt, Dennis, Lemm, Margit, Fichtner, Iduna, Schlag, Peter M., Shoemaker, Robert H., Stein, Ulrike

“…Background Metastasis formation in colon cancer severely reduces the survival rate in patients. S100A4, a calcium-binding protein, is implicated in promoting…”
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Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo by Gajer, J M, Furdas, S D, Gründer, A, Gothwal, M, Heinicke, U, Keller, K, Colland, F, Fulda, S, Pahl, H L, Fichtner, I, Sippl, W, Jung, M

“…We have previously described novel histone acetyltransferase (HAT) inhibitors that block neuroblastoma cell growth in vitro . Here we show that two selected…”
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Radiosensitisation of U87MG brain tumours by anti-epidermal growth factor receptor monoclonal antibodies by Diaz Miqueli, A, Rolff, J, Lemm, M, Fichtner, I, Perez, R, Montero, E

“…As epidermal growth factor receptor (EGFR) has been reported to be a radiation response modulator, HER inhibitors are regarded to act as potential…”
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Preclinical models of patient derived xenografts (PDX) for immuno-oncology research by Stecklum, M, Wulf-Goldenberg, A, Brzezicha, B, Fichtner, I, Hoffmann, J

“…An abstract of the study conducted by Stecklum et al determining PD-L1 expression as a target for immunotherapy on different tumor cell lines and PDX and…”
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Mouse models for translational preclinical research in immuno-oncology by Wulf-Goldenberg, A, Stecklum, M, Reiner, Z, Fichtner, I, Hoffmann, J

“…An abstract of the study conducted by Wulf-Golderberg et al focusing the use mouse models for translational preclinical research in immuno-oncology is…”
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New preclinical models for neuro-oncology: Orthotopic patient-derived glioblastoma xenografts in mice by Orthmann, A, Haybäck, J, Jödicke, A, Kuhn, S, Linnebacher, M, Fichtner, I, Hoffmann, J

“…An abstract of the study conducted by Orthmann et al initiating the development of a preclinical models for neuro-oncology, orthotopic patient-dericed…”
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INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model by Graeser, R., Esser, N., Unger, H., Fichtner, I., Zhu, A., Unger, C., Kratz, F.

“…Summary The (6-maleimidocaproyl)hydrazone derivative of doxorubicin (INNO-206) is an albumin-binding prodrug of doxorubicin with acid-sensitive properties that…”
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624: In vivo models of pancreatic cancer for translational medicine by Behrens, D, Hallas, C, Anders, D, Fichtner, I

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Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas by Fichtner, I., Slisow, W., Gill, J., Becker, M., Elbe, B., Hillebrand, T., Bibby, M.

“…Despite some success in the treatment of colorectal carcinomas, novel rational therapies targeting specific cancer-related molecules are under development and…”
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Patient-derived xenografts (PDX) from agressive haematological malignancies by Brzezicha, B, Siegert, A, Walther, W, Fichtner, I, Hoffmann, J, Karawajew, L, Schmitt, C, Janz, M

“…Aggressive B-cell lymphomas and acute myeloid leukaemia's (AML) constitute a substantial proportion of human haematological malignancies and pose an important…”
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Molecular subtypes of head and neck cancer predict response to cetuximab treatment by Klinghammer, K, Otto, R, Raguse, J.D, Albers, A, Fichtner, I, Keilholz, U, Hoffmann, J

“…An abstract of the study conducted by Klinghammer et al establishing different molecular subtypes of head and neck cancer based on gene expression patterns as…”
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Evaluation of potential predictive biomarker for cetuximab in a panel of colorectal cancer patient-derived xenografts (PDX) by Rivera, M, Hoffmann, J, Wulf-Goldenberg, A, Schlag, P.M, Merk, J, Walther, W, Fichtner, I

“…An abstract of a study by Rivera et al evaluating of potential predictive biomarker for cetuximab in a panel of colorectal cancer patient-derived xenografts…”
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Preclinical Study of a Combination of Erlotinib and Bevacizumab in Early Stages of Unselected Non-Small Cell Lung Cancer Patient-Derived Xenografts by Rolff, J., Becker, M., Merk, J., Hoffmann, J., Fichtner, I.

“…Background The differential outcomes of clinical studies of the targeted therapies for non-small cell lung cancer (NSCLC) indicate that better stratification…”
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Impact of intratumoral heterogeneity of renal cancer on drug response and development of resistance in patient derived xenografts by Zeisig, R, Flechsig, S, Wulf-Goldenberg, A, Schmees, C, Jandrig, B, Hennenlotter, J, Bedke, J, Stenzl, A, Schostak, M, Becker, M, Fichtner, I, Hoffmann, J

“…Background: Patients with advanced renal cell carcinoma (RCC) have a poor prognosis due to fast onset of resistance towards Standard of Care (SoC) drugs…”
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652: Patient-derived xenograft models of acute leukemias for translational research by Siegert, A, Brzezicha, B, Wulf-Goldenberg, A, Fichtner, I, Hoffmann, J

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10 mTOR inhibition with everolimus – a novel treatment option for head and neck cancer identified in a translational research study using patient-derived xenografts by Klinghammer, K, Raguse, J.D, Plath, T, Albers, A.E, Brzezicha, B, Wulf-Goldenberg, A, Keilholz, U, Hoffmann, J, Fichtner, I

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PO-218 Cytokine-transgenic NOG mice engrafted with human peripheral blood cells support natural killer cell expansion by Paterka, M, Volden, P, Tanaka, A, Gimnopoulos, D, Fichtner, I

“…IntroductionGiven the central role natural killer (NK) cells exert in immune responses and the great therapeutic potential they hold due to their ability to…”
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Sensitive PCR method for the detection and real-time quantification of human cells in xenotransplantation systems by BECKER, M, NITSCHE, A, NEUMANN, C, AUMANN, J, JUNGHAHN, I, FICHTNER, I

“…The sensitive detection of human cells in immunodeficient rodents is a prerequisite for the monitoring of micrometastasis of solid tumours, dissemination of…”
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Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo by BANNON, J. H, FICHTNER, I, O'NEILL, A, PAMPILLON, C, SWEENEY, N. J, STROHFELDT, K, WATSON, R. W, TACKE, M, MC GEE, M. M

“…Titanocene compounds are a novel series of agents that exhibit cytotoxic effects in a variety of human cancer cells in vitro and in vivo. In this study, the…”
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