Search Results - "I D Dukes"

Tedisamil blocks the transient and delayed rectifier K+ currents in mammalian cardiac and glial cells by Dukes, I D, Cleemann, L, Morad, M

“…The potassium currents in rat and guinea pig ventricular myocytes and mouse astrocytes were studied using tedisamil, a novel antiarrhythmic agent. A 1 to 20…”
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K+ channels: generating excitement in pancreatic beta-cells by Dukes, I. D., Philipson, L. H.

“…K+ channels: generating excitement in pancreatic beta-cells. I D Dukes and L H Philipson Glaxo Wellcome Research Institute, Research Triangle Park, North…”
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Endoplasmic reticulum calcium store regulates membrane potential in mouse islet beta-cells by J F Worley, 3rd, M S McIntyre, B Spencer, R J Mertz, M W Roe, I D Dukes

“…Glucose stimulation of islet beta-cell insulin secretion is initiated by membrane depolarization and an elevation in intracellular free calcium concentration…”
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Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans by Roe, M.W, Philipson, L.H, Frangakis, C.J, Kuznetsov, A, Mertz, R.J, Lancaster, M.E, Spencer, B, Worley, J.F. III, Dukes, I.D

“…Non-insulin-dependent diabetes mellitus (NIDDM) is a metabolic disease associated with abnormal insulin secretion, the underlying mechanisms of which are…”
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Divalent cations modulate the transient outward current in rat ventricular myocytes by Agus, Z S, Dukes, I D, Morad, M

“…The modulation of the transient outward K+ current (Ito) by divalent cations was studied in enzymatically isolated rat ventricular myocytes with the whole cell…”
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Dependence on NADH produced during glycolysis for beta-cell glucose signaling by I D Dukes, M S McIntyre, R J Mertz, L H Philipson, M W Roe, B Spencer, J F Worley, 3rd

“…An increase in cytosolic ATP following glucose metabolism by pancreatic beta-cells is the key signal initiating insulin secretion by causing blockade of…”
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The transient K+ current in rat ventricular myocytes: evaluation of its Ca2+ and Na+ dependence by Dukes, I D, Morad, M

“…1. The transient outward K+ current (Ito) was studied in enzymatically isolated rat ventricular myocytes using the whole-cell patch clamp technique. 2. At…”
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Voltage-dependent intracellular calcium release from mouse islets stimulated by glucose by Roe, M.W., Lancaster, M.E., Mertz, R.J., Worley, J.F., Dukes, I.D.

“…Glucose-activated beta-cell insulin secretion depends upon elevation of intracellular calcium concentration, [Ca2+]i, which is thought to arise from Ca2+…”
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Tedisamil inactivates transient outward K+ current in rat ventricular myocytes by Dukes, I D, Morad, M

“…The action of tedisamil, a new bradycardiac agent with antiarrhythmic properties, was investigated in single rat ventricular myocytes using the whole cell…”
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Thapsigargin inhibits the glucose-induced decrease of intracellular Ca2+ in mouse islets of Langerhans by Roe, M W, Mertz, R J, Lancaster, M E, Worley, 3rd, J F, Dukes, I D

“…Stimulation of pancreatic islets of Langerhans with glucose results in changes in intracellular Ca2+ concentration ([Ca2+]i). With the use of mouse islets…”
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Depletion of intracellular Ca2+ stores activates a maitotoxin-sensitive nonselective cationic current in beta-cells by J F Worley, 3rd, M S McIntyre, B Spencer, I D Dukes

“…Glucose stimulation of beta-cell insulin secretion is initiated by membrane depolarization coupled with an elevation in intracellular Ca2+ concentration…”
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NIDDM is associated with loss of pancreatic beta-cell L-type Ca2+ channel activity by Roe, M W, Worley, 3rd, J F, Tokuyama, Y, Philipson, L H, Sturis, J, Tang, J, Dukes, I D, Bell, G I, Polonsky, K S

“…Development of non-insulin-dependent diabetes mellitus (NIDDM) is associated with defects in glucose-stimulated insulin secretion. We have investigated Zucker…”
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Amylin Modulates β-Cell Glucose Sensing Via Effects on Stimulus- Secretion Coupling by WAGONER, P. K, CHEN CHEN, WORLEY, J. F, DUKES, I. D, OXFORD, G. S

“…The release of insulin from the pancreatic β cell is dependent upon a complex interplay between stimulators and inhibitors. Recently, amylin, a peptide…”
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Calcium current regulation of depolarization-evoked calcium transients in beta-cells (HIT-T15) by Dukes, I D, Cleemann, L

“…Glucose-induced insulin secretion by beta-cells is linked to phasic increases in intracellular Ca2+ concentration ([Ca2+]i) arising from membrane…”
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Delayed rectifier K+ channel overexpression in transgenic islets and beta-cells associated with impaired glucose responsiveness by L H Philipson, M P Rosenberg, A Kuznetsov, M E Lancaster, J F Worley, 3rd, M W Roe, I D Dukes

“…Glucose stimulation of pancreatic beta-cell insulin secretion is closely coupled to alterations in ion channel conductances and intracellular Ca2+ ([Ca2+]i)…”
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Effects of selective alpha 1-, alpha 2-, beta 1-and beta 2-adrenoceptor stimulation on potentials and contractions in the rabbit heart by Dukes, I D, Vaughan Williams, E M

“…Selective adrenoceptor agonists and antagonists have been used to analyse the effects of stimulation of individual types of adrenoceptor in various parts of…”
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Defective Pancreatic β-Cell Glycolytic Signaling in Hepatocyte Nuclear Factor-1α-deficient Mice by Dukes, Iain D., Sreenan, Seamus, Roe, Michael W., Levisetti, Matteo, Zhou, Yun-Ping, Ostrega, Diane, Bell, Graeme I., Pontoglio, Marco, Yaniv, Moshe, Philipson, Louis, Polonsky, Kenneth S.

“…Mutations in the hepatocyte nuclear factor-1α (HNF-1α) gene cause maturity onset diabetes of the young type 3, a form of type 2 diabetes mellitus. In mice…”
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The multiple modes of action of propafenone by Dukes, I D, Vaughan Williams, E M

“…Previous studies of widely different concentrations of propafenone in various species have reported that in addition to having class 1 antiarrhythmic action,…”
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Electrophysiological effects of α‐adrenoceptor antagonists in rabbit sino‐atrial node, cardiac Purkinje cells and papillary muscles by Dukes, I.D., Williams, E.M. Vaughan

“…1 The effects of prazosin, labetalol, and medroxalol were studied in the rabbit sino‐atrial node, Purkinje cells and papillary muscles. 2 At concentrations…”
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Absence of effect of culture duration on glucose-activated alterations in intracellular calcium concentration in mouse pancreatic islets by Roe, M W, Spencer, B, Lancaster, M E, Mertz, R J, Worley, 3rd, J F, Dukes, I D

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