Do cardiac risk factors affect the homocysteine and asymmetric dimethylarginine relationship in patients with coronary artery diseases?

Elevated homocysteine (Hcy) concentrations have been shown to be a risk factor for atherosclerotic vascular disease and thrombosis. Increased asymmetric dimethylarginine (ADMA) levels have been implicated in the pathogenesis of numerous conditions affecting the cardiovascular system. In this study,...

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Bibliographic Details
Published in:	Clinical biochemistry Vol. 45; no. 16-17; pp. 1325 - 1330
Main Authors:	Işıklar, Özben O., Barutcuoğlu, Burcu, Kabaroğlu, Ceyda, Mutaf, Işıl, Özmen, Dilek, Bayındır, Oya, Zoghi, Mehdi, Uluer, Hatice
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-11-2012 Elsevier
Subjects:	Adult Aged Arginine - analogs & derivatives Arginine - blood Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - blood Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular disease Coronary Artery Disease - blood Coronary heart disease Female Heart Homocysteine - blood Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Regression Analysis Risk Factors eGFR NO eNOS CAD ADMA Cardiovascular disease MDRD Risk factors HDL NT-proBNP LDL Atherosclerosis DDAH HOMA SAM BMI ELISA Hcy Human Thiol Coronary heart disease Epidemiology Sulfur containing aminoacid Vascular disease Homocystein Clinical biology Risk factor Cardiovascular risk
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Summary:	Elevated homocysteine (Hcy) concentrations have been shown to be a risk factor for atherosclerotic vascular disease and thrombosis. Increased asymmetric dimethylarginine (ADMA) levels have been implicated in the pathogenesis of numerous conditions affecting the cardiovascular system. In this study, the influence of cardiovascular risk factors and other variables on Hcy and ADMA relationship in patients with coronary artery disease (CAD) was investigated. Seventy-five patients with CAD were divided into three tertiles according to their Hcy levels. The effect of age, gender, blood pressure, lipid profile, renal function, and the presence of diabetes, insulin resistance, heart failure, inflammation, overweight, smoking and severity of coronary atherosclerosis on Hcy and ADMA relationship was evaluated. ADMA concentrations of patients in the middle and highest Hcy tertiles were significantly higher than the patients in the lowest tertile. When ADMA concentrations were adjusted for demographic, clinical and laboratory variables, the significant differences in ADMA concentrations between the tertiles were preserved. ADMA levels positively correlated with Hcy. Homocysteine levels positively correlated with serum creatinine and NT-proBNP concentrations and negatively correlated with glomerular filtration rates. Stepwise multiple regression analysis revealed Hcy as the unique predictor of ADMA levels. Homocysteine concentration has an effect on ADMA levels. There is a strong correlation between Hcy and ADMA. Cardiovascular risk factors do not have an influence on this relationship. ► Elevated homocysteine level is a risk factor for atherosclerotic vascular disease. ► Endothelial dysfunction in hyperhomocysteinemia is secondary to elevated ADMA. ► The impact of cardiovascular risk factors on Hcy- ADMA relationship is unknown. ► Hcy- ADMA relationship is independent of other cardiovascular risk factors.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-9120 1873-2933
DOI:	10.1016/j.clinbiochem.2012.06.024