Higher rates of streptococcal colonization among children in the Pacific Rim Region correlates with higher rates of group A streptococcal disease and sequelae

Higher rates of streptococcal colonization among children in the Pacific Rim Region correlates with higher rates of group A streptococcal disease and sequelae

Group A streptococcal (GAS) pharyngeal colonization rates were determined among 1061 asymptomatic students in Hawaii and American Samoa where acute rheumatic fever rates are high. All GAS isolates were emm sequence typed. Although pharyngeal colonization rates were low in Hawaii (3.4%), Pacific Isla...

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Bibliographic Details
Published in:Clinical microbiology and infection Vol. 16; no. 5; pp. 452 - 455
Main Authors: Erdem, G., Sinclair, S., Marrone, J.R., I'atala, T.F., Tuua, A., Tuua, B., Tuumua, F., Dodd, A., Mizumoto, C., Medina, L.
Format: Journal Article
Language:English
Published: Oxford, UK Elsevier Ltd 01-05-2010
Blackwell Publishing Ltd
Elsevier Limited
Subjects:
Adolescent
American Samoa - epidemiology
Antigens, Bacterial - genetics
Asymptomatic colonization
Bacterial Outer Membrane Proteins - genetics
Carrier Proteins - genetics
Carrier State - epidemiology
Carrier State - microbiology
Child
Children
Colonization
Complications
emm typing
epidemiology
Ethnic groups
Female
Hawaii - epidemiology
Humans
Infection
Male
Multivariate Analysis
Pacific Islander
Pharynx
Pharynx - microbiology
Rheumatic fever
Streptococcal Infections - epidemiology
Streptococcal Infections - microbiology
Streptococcus
Streptococcus pyogenes
Streptococcus pyogenes - genetics
Streptococcus pyogenes - isolation & purification
Hawaii
American Samoa
Asymptomatic colonization
epidemiology
Streptococcus pyogenes
Pacific Islander
emm typing
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Summary:Group A streptococcal (GAS) pharyngeal colonization rates were determined among 1061 asymptomatic students in Hawaii and American Samoa where acute rheumatic fever rates are high. All GAS isolates were emm sequence typed. Although pharyngeal colonization rates were low in Hawaii (3.4%), Pacific Islander children had significantly higher colonization rates (5.7% vs. 1.2% in other ethnic groups, p <0.05). The colonization rate was higher in American Samoa (13%). Few emm types that were infrequently observed in symptomatic infections in Hawaii were repeatedly identified in both sites. These emm types were previously described among asymptomatic children suggesting a type-specific association with pharyngeal colonization.
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Editor P. Tassios
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2009.02879.x