Search Results - "Hyvonen, M. T."

Atomistic insight into chondroitin-6-sulfate glycosaminoglycan chain through quantum mechanics calculations and molecular dynamics simulation by Cilpa, G., Hyvönen, M. T., Koivuniemi, A., Riekkola, M.-L.

“…Chondroitin‐6‐sulfate (C6S) is a glycosaminoglycan (GAG) constituent in the extracellular matrix, which participates actively in crucial biological processes,…”
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Mechanisms of polyamine catabolism-induced acute pancreatitis by Hyvönen, M T, Merentie, M, Uimari, A, Keinänen, T A, Jänne, J, Alhonen, L

“…Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the…”
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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce by Li, Qian, Hagberg, Carolina E., Silva Cascales, Helena, Lang, Shuai, Hyvönen, Mervi T., Salehzadeh, Firoozeh, Chen, Ping, Alexandersson, Ida, Terezaki, Eleni, Harms, Matthew J., Kutschke, Maria, Arifen, Nahida, Krämer, Niels, Aouadi, Myriam, Knibbe, Carole, Boucher, Jeremie, Thorell, Anders, Spalding, Kirsty L.

“…Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in…”
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Molecular Dynamics Simulations of Lipid Bilayers: Major Artifacts Due to Truncating Electrostatic Interactions by Patra, M., Karttunen, M., Hyvönen, M.T., Falck, E., Lindqvist, P., Vattulainen, I.

“…We study the influence of truncating the electrostatic interactions in a fully hydrated pure dipalmitoylphosphatidylcholine (DPPC) bilayer through 20 ns…”
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Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
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Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
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A Molecular Dynamics Approach for the Association of ApolipoproteinB-100 and Chondroitin-6-sulfate by Cilpa, G, Koivuniemi, A, Hyvönen, M. T, Riekkola, M.-L

“…A force field has been previously designed for a dodecasaccharide chain of chondroitin-6-sulfate (C6S) and has proved to yield valuable data going from basic…”
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Application of Self-Organizing Maps in Conformational Analysis of Lipids by Hyvönen, Marja T, Hiltunen, Yrjö, El-Deredy, Wael, Ojala, Timo, Vaara, Juha, Kovanen, Petri T, Ala-Korpela, Mika

“…The characteristics of lipid assemblies are important for the functions of biological membranes. This has led to an increasing utilization of molecular…”
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Altered phospholipid-apoB-100 interactions and generation of extra membrane material in proteolysis-induced fusion of LDL particles by Pentikäinen, M O, Hyvönen, M T, Oörni, K, Hevonoja, T, Korhonen, A, Lehtonen-Smeds, E M, Ala-Korpela, M, Kovanen, P T

“…Lipid droplets and membrane material are produced in the extracellular matrix of the arterial intima during atherogenesis. Both in vitro and in vivo…”
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Novel metabolically stable and functionally active mimetic of spermidine by Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.

“…Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
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Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
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Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL by Hevonoja, Tiia, Pentikäinen, Markku O, Hyvönen, Marja T, Kovanen, Petri T, Ala-Korpela, Mika

“…Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and their physiological function is to carry cholesterol to the…”
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Enantioselective synthesis of (R)- and (S)-3-methylspermidines by Khomutov, M. A., Keinanen, T. A., Hyvonen, M. T., Weisell, J., Vepsalainen, J., Alhonen, L., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown enantiomerically pure ( R )- and ( S )-1,8-diamino-3-methyl-4-azaoctane’s (3-MeSpd’s) were synthesized within 11 steps with high overall yields…”
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Chemical activation of SAT1 corrects diet-induced metabolic syndrome by Castoldi, Francesca, Hyvönen, Mervi T., Durand, Sylvère, Aprahamian, Fanny, Sauvat, Allan, Malik, Shoaib A., Baracco, Elisa Elena, Vacchelli, Erika, Opolon, Paule, Signolle, Nicolas, Lefevre, Déborah, Bossut, Noelie, Eisenberg, Tobias, Dammbrueck, Christopher, Pendl, Tobias, Kremer, Margerie, Lachkar, Sylvie, Einer, Claudia, Michalke, Bernhard, Zischka, Hans, Madeo, Frank, Keinänen, Tuomo A., Maiuri, Maria Chiara, Pietrocola, Federico, Kroemer, Guido

“…The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several…”
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Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines by Khomutov, M A, Keinanen, T A, Hyvonen, M T, Weisell, J, Vepsalainen, J, Alhonen, L, Kochetkov, S N, Khomutov, A R

“…Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity…”
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Lessons of Slicing Membranes: Interplay of Packing, Free Area, and Lateral Diffusion in Phospholipid/Cholesterol Bilayers by Falck, Emma, Patra, Michael, Karttunen, Mikko, Hyvönen, Marja T., Vattulainen, Ilpo

“…We employ 100-ns molecular dynamics simulations to study the influence of cholesterol on structural and dynamic properties of dipalmitoylphosphatidylcholine…”
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Maintenance of white adipose tissue in man by Hyvönen, Mervi T., Spalding, Kirsty L.

“…Obesity is increasing in an epidemic manner in most countries and constitutes a public health problem by enhancing the risk for diseases such as diabetes,…”
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Structure and Dynamics of Sphingomyelin Bilayer: Insight Gained through Systematic Comparison to Phosphatidylcholine by Niemelä, Perttu, Hyvönen, Marja T., Vattulainen, Ilpo

“…Sphingomyelin, one of the main lipid components of biological membranes, is actively involved in various cellular processes such as protein trafficking and…”
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