Search Results - "Hyvönen, T"

Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce by Li, Qian, Hagberg, Carolina E., Silva Cascales, Helena, Lang, Shuai, Hyvönen, Mervi T., Salehzadeh, Firoozeh, Chen, Ping, Alexandersson, Ida, Terezaki, Eleni, Harms, Matthew J., Kutschke, Maria, Arifen, Nahida, Krämer, Niels, Aouadi, Myriam, Knibbe, Carole, Boucher, Jeremie, Thorell, Anders, Spalding, Kirsty L.

“…Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in…”
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Polyunsaturation in Lipid Membranes:  Dynamic Properties and Lateral Pressure Profiles by Ollila, Samuli, Hyvönen, Marja T, Vattulainen, Ilpo

“…We elucidate the influence of unsaturation on single-component membrane properties, focusing on their dynamical aspects and lateral pressure profiles across…”
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Chemical activation of SAT1 corrects diet-induced metabolic syndrome by Castoldi, Francesca, Hyvönen, Mervi T., Durand, Sylvère, Aprahamian, Fanny, Sauvat, Allan, Malik, Shoaib A., Baracco, Elisa Elena, Vacchelli, Erika, Opolon, Paule, Signolle, Nicolas, Lefevre, Déborah, Bossut, Noelie, Eisenberg, Tobias, Dammbrueck, Christopher, Pendl, Tobias, Kremer, Margerie, Lachkar, Sylvie, Einer, Claudia, Michalke, Bernhard, Zischka, Hans, Madeo, Frank, Keinänen, Tuomo A., Maiuri, Maria Chiara, Pietrocola, Federico, Kroemer, Guido

“…The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several…”
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Role of lipids in spheroidal high density lipoproteins by Vuorela, Timo, Catte, Andrea, Niemelä, Perttu S, Hall, Anette, Hyvönen, Marja T, Marrink, Siewert-Jan, Karttunen, Mikko, Vattulainen, Ilpo

“…We study the structure and dynamics of spherical high density lipoprotein (HDL) particles through coarse-grained multi-microsecond molecular dynamics…”
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Lessons of Slicing Membranes: Interplay of Packing, Free Area, and Lateral Diffusion in Phospholipid/Cholesterol Bilayers by Falck, Emma, Patra, Michael, Karttunen, Mikko, Hyvönen, Marja T., Vattulainen, Ilpo

“…We employ 100-ns molecular dynamics simulations to study the influence of cholesterol on structural and dynamic properties of dipalmitoylphosphatidylcholine…”
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Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C‑Methylated Spermine Derivatives by Khomutov, Maxim, Hyvönen, Mervi T, Simonian, Alina, Formanovsky, Andrey A, Mikhura, Irina V, Chizhov, Alexander O, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in…”
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Impact of changed cropping practices on weed occurrence in spring cereals in Finland - a comparison of surveys in 1997-1999 and 2007-2009 by SALONEN, J, HYVÖNEN, T, KASEVA, J, JALLI, H

“…Salonen J, Hyvönen T, Kaseva J & Jalli H (2012). Impact of changed cropping practices on weed occurrence in spring cereals in Finland – a comparison of surveys…”
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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Control of Heracleum mantegazzianum with pyrolysis liquid products by Hyvönen, Terho T., Hagner, Marleena M., Hurme, Timo K., Lindqvist, Bengt E., Ojanen, Hannu J.

“…Abstract Heracleum mantegazzianum is an invasive environmental weed that is widely distributed in Europe and whose distribution is continually expanding. Novel…”
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Atom-scale molecular interactions in lipid raft mixtures by Niemelä, Perttu S., Hyvönen, Marja T., Vattulainen, Ilpo

“…We review the relationship between molecular interactions and the properties of lipid environments. A specific focus is given on bilayers which contain…”
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Maintenance of white adipose tissue in man by Hyvönen, Mervi T., Spalding, Kirsty L.

“…Obesity is increasing in an epidemic manner in most countries and constitutes a public health problem by enhancing the risk for diseases such as diabetes,…”
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Lipid Bilayers Driven to a Wrong Lane in Molecular Dynamics Simulations by Subtle Changes in Long-Range Electrostatic Interactions by Patra, Michael, Karttunen, Mikko, Hyvönen, Marja T, Falck, Emma, Vattulainen, Ilpo

“…We provide compelling evidence that different treatments of electrostatic interactions in molecular dynamics simulations may dramatically affect dynamic…”
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Molecular Dynamics Simulations of Lipid Bilayers: Major Artifacts Due to Truncating Electrostatic Interactions by Patra, M., Karttunen, M., Hyvönen, M.T., Falck, E., Lindqvist, P., Vattulainen, I.

“…We study the influence of truncating the electrostatic interactions in a fully hydrated pure dipalmitoylphosphatidylcholine (DPPC) bilayer through 20 ns…”
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Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL by Hevonoja, Tiia, Pentikäinen, Markku O, Hyvönen, Marja T, Kovanen, Petri T, Ala-Korpela, Mika

“…Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and their physiological function is to carry cholesterol to the…”
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Crop–weed competition rather than temperature limits the population establishment of two annual C₄ weeds at the edge of their northern range by Hyvönen, T, Ramula, S, Bastiaans, Lammert

“…Climate change is predicted to affect range expansion of harmful C₄ weeds into the boreal region, given that they are able to successfully colonise both C₃ and…”
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Membrane simulations mimicking acidic pH reveal increased thickness and negative curvature in a bilayer consisting of lysophosphatidylcholines and free fatty acids by Lähdesmäki, Katariina, Ollila, O.H. Samuli, Koivuniemi, Artturi, Kovanen, Petri T., Hyvönen, Marja T.

“…Phospholipids are key components of biological membranes and their lipolysis with phospholipase A2 (PLA2) enzymes occurs in different cellular pH environments…”
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Impact of cholesterol on voids in phospholipid membranes by Falck, Emma, Patra, Michael, Karttunen, Mikko, Hyvönen, Marja T, Vattulainen, Ilpo

“…Free volume pockets or voids are important to many biological processes in cell membranes. Free volume fluctuations are a prerequisite for diffusion of lipids…”
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Role of Hypusinated Eukaryotic Translation Initiation Factor 5A in Polyamine Depletion-induced Cytostasis by Hyvönen, Mervi T., Keinänen, Tuomo A., Cerrada-Gimenez, Marc, Sinervirta, Riitta, Grigorenko, Nikolay, Khomutov, Alex R., Vepsäläinen, Jouko, Alhonen, Leena, Jänne, Juhani

“…We have earlier shown that α-methylated spermidine and spermine analogues rescue cells from polyamine depletion-induced growth inhibition and maintain…”
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Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues by Weisell, Janne, Hyvönen, Mervi T, Häkkinen, Merja R, Grigorenko, Nikolay A, Pietilä, Marko, Lampinen, Anita, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Biogenic polyamines, spermidine and spermine, are positively charged at physiological pH. They are present in all cells and essential for their growth and…”
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Impact of temperature and germination time on the success of a C4 weed in a C3 crop : Amaranthus retroflexus and spring barley by Hyvönen, Terho

“…Elevation in temperatures due to climate change could promote the invasion by C4 weed species of arable fields in the boreal region, which are dominated by C3…”
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