Search Results - "Hyvönen, M."

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway by Saurus, P, Kuusela, S, Lehtonen, E, Hyvönen, M E, Ristola, M, Fogarty, C L, Tienari, J, Lassenius, M I, Forsblom, C, Lehto, M, Saleem, M A, Groop, P-H, Holthöfer, H, Lehtonen, S

“…High serum lipopolysaccharide (LPS) activity in normoalbuminuric patients with type 1 diabetes (T1D) predicts the progression of diabetic nephropathy (DN), but…”
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Molecular Dynamics Simulations of Lipid Bilayers: Major Artifacts Due to Truncating Electrostatic Interactions by Patra, M., Karttunen, M., Hyvönen, M.T., Falck, E., Lindqvist, P., Vattulainen, I.

“…We study the influence of truncating the electrostatic interactions in a fully hydrated pure dipalmitoylphosphatidylcholine (DPPC) bilayer through 20 ns…”
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Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase by Battisti, Umberto Maria, Gao, Chunxia, Nilsson, Oscar, Akladios, Fady, Lulla, Aleksei, Bogucka, Agnieszka, Nain‐Perez, Amalyn, Håversen, Liliana, Kim, Woonghee, Boren, Jan, Hyvönen, Marko, Uhlen, Mathias, Mardinoglu, Adil, Grøtli, Morten

“…Enzymes are effective biological catalysts that accelerate almost all metabolic reactions in living organisms. Synthetic modulators of enzymes are useful tools…”
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Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF by Meng, Xiaojuan, Lindahl, Maria, Hyvönen, Mervi E., Parvinen, Martti, de Rooij, Dirk G., Hess, Michael W., Raatikainen-Ahokas, Anne, Sainio, Kirsi, Rauvala, Heikki, Lakso, Merja, Pichel, José G., Westphal, Heiner, Saarma, Mart, Sariola, Hannu

“…The molecular control of self-renewal and differentiation of stem cells has remained enigmatic. Transgenic loss-of-function and overexpression models now show…”
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INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy by Hyvönen, M. E., Ihalmo, P., Forsblom, C., Thorn, L., Sandholm, N., Lehtonen, S., Groop, P.-H.

“…Diabet. Med. 29, 1589–1595 (2012) Aims  The metabolic syndrome is a frequent phenomenon in people with Type 1 diabetes and is associated with diabetic…”
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A Molecular Dynamics Approach for the Association of ApolipoproteinB-100 and Chondroitin-6-sulfate by Cilpa, G, Koivuniemi, A, Hyvönen, M. T, Riekkola, M.-L

“…A force field has been previously designed for a dodecasaccharide chain of chondroitin-6-sulfate (C6S) and has proved to yield valuable data going from basic…”
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The role of CD109 in glioma progression by Filppu, P, Le Joncour, V, Hyvönen, M, Sihto, H, Joensuu, H, Lehti, K, Laakkonen, P

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Treating malignant glioma and brain metastasis with nanoparticles: Challenges of a peptide-based targeting and passage through the blood–brain-barrier by Le Joncour, V, Hyvönen, M, Casals, E, Filppu, P, Ramanathan, J. Tanjore, Ayo, A, Westermarck, J, Rosenholm, J, Laakkonen, P

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Structure of the binding site for inositol phosphates in a PH domain by Hyvönen, M., Macias, M. J., Nilges, M., Oschkinat, H., Saraste, M., Wilmanns, M.

“…Phosphatidylinositol bisphosphate has been found to bind specifically to pleckstrin homology (PH) domains that are commonly present in signalling proteins but…”
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Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide by Macias, Maria J, Hyvönen, Marko, Baraldi, Elena, Schultz, Johan, Sudol, Marius, Saraste, Matti, Oschkinat, Hartmut

“…The WW domain is a new protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro. It is present in a number of…”
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Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment by VANHANEN, H. T, BLOMQVIST, S, EHNHOLM, C, HYVÖNEN, M, JAUHIAINEN, M, TORSTILA, I, MIETTINEN, T. A

“…A randomized double-blind study was made in modestly hypercholesterolemic subjects by replacing 50 g of daily dietary fat by the same amount of a rapeseed oil…”
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Structure of low density lipoprotein (LDL) particles: Basis for understanding molecular changes in modified LDL by Hevonoja, Tiia, Pentikäinen, Markku O, Hyvönen, Marja T, Kovanen, Petri T, Ala-Korpela, Mika

“…Low density lipoprotein (LDL) particles are the major cholesterol carriers in circulation and their physiological function is to carry cholesterol to the…”
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Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
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Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia by Hyvönen, Marko, Saraste, Matti

“…Bruton's tyrosine kinase (Btk) is an enzyme which is involved in maturation of B cells. It is a target for mutations causing X‐linked agammaglobulinaemia (XLA)…”
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Dose-dependent suppression of the neutrophil respiratory burst by lidocaine by Hyvönen, P. M., Kowolik, M. J.

“…Background: Oxygen radical production is thought to be fundamental to the pathogenesis of post‐ischaemic reperfusion injury which is routinely managed with…”
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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce by Li, Qian, Hagberg, Carolina E., Silva Cascales, Helena, Lang, Shuai, Hyvönen, Mervi T., Salehzadeh, Firoozeh, Chen, Ping, Alexandersson, Ida, Terezaki, Eleni, Harms, Matthew J., Kutschke, Maria, Arifen, Nahida, Krämer, Niels, Aouadi, Myriam, Knibbe, Carole, Boucher, Jeremie, Thorell, Anders, Spalding, Kirsty L.

“…Obesity is considered an important factor for many chronic diseases, including diabetes, cardiovascular disease and cancer. The expansion of adipose tissue in…”
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Novel target for peptide-based imaging and treatment of brain tumors by Hyvönen, Maija, Enbäck, Juulia, Huhtala, Tuulia, Lammi, Johanna, Sihto, Harri, Weisell, Janne, Joensuu, Heikki, Rosenthal-Aizman, Katri, El-Andaloussi, Samir, Langel, Ulo, Närvänen, Ale, Bergers, Gabriele, Laakkonen, Pirjo

“…Malignant gliomas are associated with high mortality due to infiltrative growth, recurrence, and malignant progression. Even with the most efficient therapy…”
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Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Atomistic insight into chondroitin-6-sulfate glycosaminoglycan chain through quantum mechanics calculations and molecular dynamics simulation by Cilpa, G., Hyvönen, M. T., Koivuniemi, A., Riekkola, M.-L.

“…Chondroitin‐6‐sulfate (C6S) is a glycosaminoglycan (GAG) constituent in the extracellular matrix, which participates actively in crucial biological processes,…”
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