Effect of Anti-IgE Therapy in Patients with Peanut Allergy

Effect of Anti-IgE Therapy in Patients with Peanut Allergy

Injections of TNX-901 may provide protection after ingestion of peanut. Peanut allergy is characterized by symptoms and signs after ingestion that may include nausea, vomiting, diarrhea, abdominal pain, urticaria, angioedema, bronchospasm, hypotension, loss of consciousness, and death. 1 , 2 Althoug...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 348; no. 11; pp. 986 - 993
Main Authors: Leung, Donald Y.M, Sampson, Hugh A, Yunginger, John W, Burks, A. Wesley, Schneider, Lynda C, Wortel, Cornelis H, Davis, Frances M, Hyun, John D, Shanahan, William R
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 13-03-2003
Subjects:
Adolescent
Adult
Allergies
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antibodies, Monoclonal, Humanized
Biological and medical sciences
Digestive system
Double-Blind Method
Female
Food allergies
Humans
Immunoglobulin E - blood
Immunoglobulin E - immunology
Immunoglobulin G - immunology
Male
Medical sciences
Middle Aged
Peanut Hypersensitivity - drug therapy
Peanut Hypersensitivity - immunology
Pharmacology. Drug treatments
United States > US
Human
Immunopathology
Allergy
Peanut
Chemotherapy
Sensitivity
Treatment
Secondary effect
IgG1
Monoclonal antibody
Threshold
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Description
Summary:Injections of TNX-901 may provide protection after ingestion of peanut. Peanut allergy is characterized by symptoms and signs after ingestion that may include nausea, vomiting, diarrhea, abdominal pain, urticaria, angioedema, bronchospasm, hypotension, loss of consciousness, and death. 1 , 2 Although data from animals demonstrate that allergic reactions are mediated by antigen-specific IgE bound to high-affinity receptors for IgE (FcεRIs) on mast cells and basophils, 3 , 4 non-IgE pathways for anaphylaxis exist, at least in mice, 5 , 6 and direct clinical evidence of IgE involvement in peanut allergy in humans is lacking. Approximately 1.5 million people in the United States have peanut allergy, 7 , 8 50 to 100 of whom die each year from unintended . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ObjectType-News-3
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa022613