Search Results - "Hyun, Jeongeun"

DNA Methylation in Nonalcoholic Fatty Liver Disease by Hyun, Jeongeun, Jung, Youngmi

“…Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United States and other Westernized countries. Nonalcoholic steatohepatitis…”
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Pathophysiological Aspects of Alcohol Metabolism in the Liver by Hyun, Jeongeun, Han, Jinsol, Lee, Chanbin, Yoon, Myunghee, Jung, Youngmi

“…Alcoholic liver disease (ALD) is a globally prevalent chronic liver disease caused by chronic or binge consumption of alcohol. The liver is the major organ…”
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Ursolic acid: A promising therapeutic agent for metabolic dysfunction-associated steatotic liver disease via inhibition of SPP1-induced Th17 cell differentiation: Editorial on “Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against metabolic dysfunction-associated steatotic liver disease” by Kim, So Jung, Hyun, Jeongeun

“…[...]assessment showed significant improvements in hepatic gene expression of pro-inflammatory cytokines, including transforming growth factor (TGF)-β,…”
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MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression by Hyun, Jeongeun, Wang, Sihyung, Kim, Jieun, Rao, Kummara Madhusudana, Park, Soo Yong, Chung, Ildoo, Ha, Chang-Sik, Kim, Sang-Woo, Yun, Yang H., Jung, Youngmi

“…Hedgehog (Hh) signalling regulates hepatic fibrogenesis. MicroRNAs (miRNAs) mediate various cellular processes; however, their role in liver fibrosis is…”
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MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells by Hyun, Jeongeun, Wang, Sihyung, Kim, Jieun, Kim, Gi Jin, Jung, Youngmi

“…Although chorionic plate-derived mesenchymal stem cells (CP-MSCs) were shown to promote liver regeneration, the mechanisms underlying the effect remain…”
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Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease: insights and therapeutic implications by Kim, So Jung, Hyun, Jeongeun

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miRNA-199b-5p suppresses of oral squamous cell carcinoma by targeting apical-basolateral polarity via Scribble/Lgl by Kim, Shihyun, Park, Suyeon, Kim, Yong-Jae, Hyun, Jeongeun, Choi, Jongho

“…In epithelial cells, Scribble forms cell-cell junctions and contributes to cell morphology and homeostasis by regulating apical-basolateral polarity in mammals…”
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Potential role of Hedgehog pathway in liver response to radiation by Wang, Sihyung, Lee, Youngjae, Kim, Jieun, Hyun, Jeongeun, Lee, Keumju, Kim, Younghwa, Jung, Youngmi

“…Radiation-induced fibrosis constitutes a major problem that is commonly observed in the patients undergoing radiotherapy; therefore, understanding its…”
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Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach by Kim, Sung-Jun, Kim, So-Jung, Hyun, Jeongeun, Kim, Hae-Won, Jang, Jun-Hyeog

“…Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment attributed to factors like obesity and diabetes. While ongoing research…”
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Editorial Expression of Concern: Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice by Wang, Sihyung, Lee, Chanbin, Kim, Jieun, Hyun, Jeongeun, Lim, Minso, Cha, Hyuk-Jin, Oh, Seh-Hoon, Choi, Yung Hyun, Jung, Youngmi

“…An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1038/s12276-021-00554-6…”
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Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression by Du, Kuo, Chitneni, Satish K., Suzuki, Ayako, Wang, Ying, Henao, Ricardo, Hyun, Jeongeun, Premont, Richard T., Naggie, Susanna, Moylan, Cynthia A., Bashir, Mustafa R., Abdelmalek, Manal F., Diehl, Anna Mae

“…Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate…”
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Alterations in DNA methylation associate with fatty liver and metabolic abnormalities in a multi-ethnic cohort of pre-teenage children by Moylan, Cynthia A., Mavis, Alisha M., Jima, Dereje, Maguire, Rachel, Bashir, Mustafa, Hyun, Jeongeun, Cabezas, Melanie N., Parish, Alice, Niedzwiecki, Donna, Diehl, Anna Mae, Murphy, Susan K., Abdelmalek, Manal F., Hoyo, Cathrine

“…Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation…”
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Hepatic stellate cells express thymosin Beta 4 in chronically damaged liver by Kim, Jieun, Wang, Sihyung, Hyun, Jeongeun, Choi, Steve S, Cha, Heejae, Ock, Meesun, Jung, Youngmi

“…Although the various biological roles of thymosin β4 (Tβ4) have been studied widely, the effect of Tβ4 and Tβ4-expressing cells in the liver remains unclear…”
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MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer by Lee, Na-Hyun, Kim, So Jung, Hyun, Jeongeun

“…Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality rate are increasing due to the lack of biomarkers and effective…”
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MicroRNA Expression Profiling in CCl₄-Induced Liver Fibrosis of Mus musculus by Hyun, Jeongeun, Park, Jungwook, Wang, Sihyung, Kim, Jieun, Lee, Hyun-Hee, Seo, Young-Su, Jung, Youngmi

“…Liver fibrosis is a major pathological feature of chronic liver diseases, including liver cancer. MicroRNAs (miRNAs), small noncoding RNAs, regulate gene…”
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Hedgehog Signaling Regulates the Repair Response in Mouse Liver Damaged by Irradiation by Wang, Sihyung, Hyun, Jeongeun, Youn, BuHyun, Jung, Youngmi

“…Radiotherapy is commonly used in treating many kinds of cancers that cannot be cured by other therapeutic strategies. However, radiation-induced fibrosis in…”
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Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling by Kim, Jieun, Hyun, Jeongeun, Wang, Sihyung, Lee, Chanbin, Lee, Jae-Wook, Moon, Eun-Yi, Cha, Heejae, Diehl, Anna Mae, Jung, Youngmi

“…The molecular mechanisms of thymosin beta-4 (TB4) involved in regulating hepatic stellate cell (HSC) functions remain unclear. Therefore, we hypothesize that…”
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RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts by Wang, Sihyung, Jung, Youngmi, Hyun, Jeongeun, Friedersdorf, Matthew, Oh, Seh-Hoon, Kim, Jieun, Premont, Richard T., Keene, Jack D., Diehl, Anna Mae

“…Abstract Background/Aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in…”
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Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice by Kim, Jieun, Wang, Sihyung, Hyun, Jeongeun, Guy, Cynthia D., Jung, Youngmi

“…Background/Aims: Radiation-induced liver disease (RILD) is a major obstacle in treating liver cancer; however, the mechanisms underlying RILD development…”
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Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development by Karunasagara, Shanika, Taghizadeh, Ali, Kim, Sang‐Hyun, Kim, So Jung, Kim, Yong‐Jae, Taghizadeh, Mohsen, Kim, Moon‐Young, Oh, Kyu‐Young, Lee, Jung‐Hwan, Kim, Hye Sung, Hyun, Jeongeun, Kim, Hae‐Won

“…Epithelial‐stromal interplay through chemomechanical cues from cells and matrix propels cancer progression. Elevated tissue stiffness in potentially malignant…”
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