Search Results - "Hyttinen, Juha"

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan by Salminen, Antero, Hyttinen, Juha M. T., Kaarniranta, Kai

“…Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy metabolic homeostasis and thus a major survival factor in a variety of…”
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Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases by Hyttinen, Juha M.T, Amadio, Marialaura, Viiri, Johanna, Pascale, Alessia, Salminen, Antero, Kaarniranta, Kai

“…Highlights • Cellular protein aggregation is connected to ageing and to various age-related diseases. • Aggrephagy is a selective form of autophagy. •…”
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Maturation of autophagosomes and endosomes: A key role for Rab7 by Hyttinen, Juha M.T., Niittykoski, Minna, Salminen, Antero, Kaarniranta, Kai

“…Macroautophagy is an important route in cellular maintenance, in the breakdown and reuse of intracellular materials. It is closely related to endocytosis, the…”
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Mitochondrial quality control in AMD: does mitophagy play a pivotal role? by Hyttinen, Juha M. T., Viiri, Johanna, Kaarniranta, Kai, Błasiak, Janusz

“…Age-related macular degeneration (AMD) is the predominant cause of visual loss in old people in the developed world, whose incidence is increasing. This…”
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DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells – Implications for age-related macular degeneration (AMD) by Hyttinen, Juha M.T, Błasiak, Janusz, Niittykoski, Minna, Kinnunen, Kati, Kauppinen, Anu, Salminen, Antero, Kaarniranta, Kai

“…Highlights • AMD is a major and emerging cause of vision loss in the elderly. • reactive oxygen species induce DNA damage, which can contribute to AMD. •…”
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MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy by Hyttinen, Juha M.T., Blasiak, Janusz, Felszeghy, Szabolcs, Kaarniranta, Kai

“…•Autophagy weakening has been suggested to be a mechanism for the pathogenesis of AMD.•Several microRNA, which are dysregulated in AMD subjects, do control…”
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UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells by Korhonen, Eveliina, Bisevac, Jovana, Hyttinen, Juha M T, Piippo, Niina, Hytti, Maria, Kaarniranta, Kai, Petrovski, Goran, Kauppinen, Anu

“…The cornea is continually exposed to highly energetic solar UV-B (280-320 nm). Our aim was to investigate whether UV-B triggers the activation of NLRP3…”
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Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells by Viiri, Johanna, Amadio, Marialaura, Marchesi, Nicoletta, Hyttinen, Juha M T, Kivinen, Niko, Sironen, Reijo, Rilla, Kirsi, Akhtar, Saeed, Provenzani, Alessandro, D'Agostino, Vito Giuseppe, Govoni, Stefano, Pascale, Alessia, Agostini, Hansjurgen, Petrovski, Goran, Salminen, Antero, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal…”
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Non-Coding RNAs Regulating Mitochondrial Functions and the Oxidative Stress Response as Putative Targets against Age-Related Macular Degeneration (AMD) by Hyttinen, Juha M T, Blasiak, Janusz, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which reduces the quality of life of millions of elderly people around the…”
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The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology by Hyttinen, Juha M T, Kannan, Ram, Felszeghy, Szabolcs, Niittykoski, Minna, Salminen, Antero, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is a mounting cause of loss of sight in the elderly in the developed countries, a trend enhanced by the continual ageing…”
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Only IL‐1β release is inflammasome‐dependent upon ultraviolet B irradiation although IL‐18 is also secreted by Korhonen, Eveliina, Piippo, Niina, Hytti, Maria, Hyttinen, Juha M. T., Kaarniranta, Kai, Kauppinen, Anu

“…DNA damage accumulates in aged postmitotic retinal pigment epithelium (RPE) cells, a phenomenon associated with the development of age‐related macular…”
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Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2 / PGC-1α -/- Mouse Model by Sridevi Gurubaran, Iswariyaraja, Viiri, Johanna, Koskela, Ali, Hyttinen, Juha M T, Paterno, Jussi J, Kis, Gréta, Antal, Miklós, Urtti, Arto, Kauppinen, Anu, Felszeghy, Szabolcs, Kaarniranta, Kai

“…Increased oxidative stress and mitochondrial damage are observed in protein aggregation diseases, such as age-related macular degeneration (AMD). We have…”
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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration by Felszeghy, Szabolcs, Viiri, Johanna, Paterno, Jussi J, Hyttinen, Juha M T, Koskela, Ali, Chen, Mei, Leinonen, Henri, Tanila, Heikki, Kivinen, Niko, Koistinen, Arto, Toropainen, Elisa, Amadio, Marialaura, Smedowski, Adrian, Reinisalo, Mika, Winiarczyk, Mateusz, Mackiewicz, Jerzy, Mutikainen, Maija, Ruotsalainen, Anna-Kaisa, Kettunen, Mikko, Jokivarsi, Kimmo, Sinha, Debasish, Kinnunen, Kati, Petrovski, Goran, Blasiak, Janusz, Bjørkøy, Geir, Koskelainen, Ari, Skottman, Heli, Urtti, Arto, Salminen, Antero, Kannan, Ram, Ferrington, Deborah A, Xu, Heping, Levonen, Anna-Liisa, Tavi, Pasi, Kauppinen, Anu, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed…”
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Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy by Kauppinen, Anu, Kaarniranta, Kai, Roehrich, Heidi, Hyttinen, Juha M. T., Korhonen, Eveliina, Hytti, Maria, Ferrington, Deborah A.

“…Mitochondrial dysfunction has been implicated in a wide variety of degenerative diseases, including age-related macular degeneration. Damage to mitochondria…”
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Potential of Long Non-Coding RNAs in Age-Related Macular Degeneration by Blasiak, Janusz, Hyttinen, Juha M T, Szczepanska, Joanna, Pawlowska, Elzbieta, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is the leading cause of visual impairment in the aging population with poorly known pathogenesis and lack of effective…”
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Autophagy in drusen biogenesis secondary to age‐related macular degeneration by Hyttinen, Juha M. T., Koskela, Ali, Blasiak, Janusz, Kaarniranta, Kai

“…Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the…”
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Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3[S] by Rilla, Kirsi, Oikari, Sanna, Jokela, Tiina A., Hyttinen, Juha M.T., Kärnä, Riikka, Tammi, Raija H., Tammi, Markku I.

“…Mammals have three homologous genes encoding proteins with hyaluronan synthase activity (Has1–3), all producing an identical polymer from…”
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SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1β-stimulated human retinal pigment epithelial cells by Korhonen, Eveliina, Piippo, Niina, Hytti, Maria, Hyttinen, Juha M.T., Kaarniranta, Kai, Kauppinen, Anu

“…•SQSTM1/p62 is required for the production of IL-8 upon IL-1β exposure.•Absence of SQSTM1/p62 promotes the production of MCP-1.•SQSTM1/p62 has no role in the…”
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Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization by Salminen, Antero, Kauppinen, Anu, Hyttinen, Juha Mt, Toropainen, Elisa, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) can be classified into two main categories: the atrophic, dry form and the exudative, wet form. The crucial difference…”
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Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice by Blasiak, Janusz, Koskela, Ali, Pawlowska, Elzbieta, Liukkonen, Mikko, Ruuth, Johanna, Toropainen, Elisa, Hyttinen, Juha M T, Viiri, Johanna, Eriksson, John E, Xu, Heping, Chen, Mei, Felszeghy, Szabolcs, Kaarniranta, Kai

“…Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we…”
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