Search Results - "Hyrup, Birgitte"

Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration by Sander, Camilla, Madsen, Katrine Dragsbæk, Hyrup, Birgitte, Nielsen, Hanne Mørck, Rantanen, Jukka, Jacobsen, Jette

“…[Display omitted] Delivery of drugs into or via the oral cavity offers some distinct advantages due to the easy access to the oral mucosa, fast onset of…”
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Structure-Activity Studies of the Binding of Modified Peptide Nucleic Acids (PNAs) to DNA by Hyrup, Birgitte, Egholm, Michael, Nielsen, Peter E, Wittung, Pernilla, Norden, Bengt, Buchardt, Ole

“…Peptide nucleic acid (PNA) oligomers where one of the repeating backbone units is extended with a methylene group to either N-(2-aminoethyl)- beta -alanine or…”
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Permeability Barriers for Nicotine and Mannitol in Porcine Buccal Mucosa Studied by High-Resolution MALDI Mass Spectrometry Imaging by Marxen, Eva, Jacobsen, Jette, Hyrup, Birgitte, Janfelt, Christian

“…Improved nicotine permeability across buccal mucosa may enable more effective oromucosal nicotine replacement therapy products. It is essential to know the…”
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A randomized phase III trial for alleviating radiation-induced xerostomia with chewing gum by Kaae, Julie Killerup, Stenfeldt, Lone, Hyrup, Birgitte, Brink, Carsten, Eriksen, Jesper Grau

“…•Xerostomia impacts quality of life for head and neck cancer survivors.•Xerostomia-related quality of life improves after intervention with chewing…”
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Effect of Permeation Enhancers on the Buccal Permeability of Nicotine: Ex vivo Transport Studies Complemented by MALDI MS Imaging by Marxen, Eva, Jin, Liang, Jacobsen, Jette, Janfelt, Christian, Hyrup, Birgitte, Nicolazzo, Joseph A.

“…Purpose The purpose of this study was to assess the effect of several chemical permeation enhancers on the buccal permeability of nicotine and to image the…”
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Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa by Meng-Lund, Emil, Marxen, Eva, Pedersen, Anne Marie L, Müllertz, Anette, Hyrup, Birgitte, Holm, Rene, Jacobsen, Jette

“…The pH partition theory proposes a correlation between fraction of unionized drug substance and permeability. The aim of this study was to compare the…”
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X-ray crystal struture of a dimethylene sulfone-bridged ribonucleotide dimer in a single-stranded state by Hyrup, Birgitte, Richert, Clemens, Schulte-Herbrüggen, Thomas, Benner, Steven A., Egli, Martin

“…A crystal structure has been solved for an analog of the r(ApU) rlbodinucleotlde, n(Aso2U), where a bridging non-ionic dimethylene surf one linker replaces the…”
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Peptide Nucleic Acids (PNA): Synthesis, properties and potential applications by Hyrup, Birgitte, Nielsen, Peter E.

“…This review summarizes our present knowledge about Peptide nucleic acids (PNA), a DNA mimic with a pseudopeptide backbone…”
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The MediChew technology platform by Hyrup, Birgitte, Andersen, Carsten, Andreasen, Lars Vibe, Tandrup, Bo, Christensen, Torben

“…A few decades ago, chewing gum was rarely considered when industry searched for an applicable delivery vehicle for an active pharmaceutical substance. Yet, the…”
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A flexible and positively charged PNA analogue with an ethylene-linker to the nucleobase: Synthesis and hybridization properties by Hyrup, Birgitte, Egholm, Michael, Buchardt, Ole, Nielsen, Peter E.

“…The positively charged and relatively flexible PNA unit ethT (Fig. 1) has an ethylene linker between backbone and nucleobase rather than the methylene carbonyl…”
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Chimera of Dimethylene Sulfone-, Methyl Sulfide-, and Methyl Sulfoxide-Linked Ribonucleotides and DNA by Baeschlin, Daniel K, Hyrup, Birgitte, Benner, Steven A, Richert, Clemens

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