Search Results - "Hyrien, Olivier"

Peaks cloaked in the mist: the landscape of mammalian replication origins by Hyrien, Olivier

“…Replication of mammalian genomes starts at sites termed replication origins, which historically have been difficult to locate as a result of large genome…”
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How MCM loading and spreading specify eukaryotic DNA replication initiation sites by Hyrien, Olivier

“…DNA replication origins strikingly differ between eukaryotic species and cell types. Origins are localized and can be highly efficient in budding yeast, are…”
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Replication landscape of the human genome by Petryk, Nataliya, Kahli, Malik, d'Aubenton-Carafa, Yves, Jaszczyszyn, Yan, Shen, Yimin, Silvain, Maud, Thermes, Claude, Chen, Chun-Long, Hyrien, Olivier

“…Despite intense investigation, human replication origins and termini remain elusive. Existing data have shown strong discrepancies. Here we sequenced highly…”
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Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse by Tubbs, Anthony, Sridharan, Sriram, van Wietmarschen, Niek, Maman, Yaakov, Callen, Elsa, Stanlie, Andre, Wu, Wei, Wu, Xia, Day, Amanda, Wong, Nancy, Yin, Mianmian, Canela, Andres, Fu, Haiqing, Redon, Christophe, Pruitt, Steven C., Jaszczyszyn, Yan, Aladjem, Mirit I., Aplan, Peter D., Hyrien, Olivier, Nussenzweig, André

“…Replication origins, fragile sites, and rDNA have been implicated as sources of chromosomal instability. However, the defining genomic features of replication…”
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Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths by Arbona, Jean-Michel, Kabalane, Hadi, Barbier, Jeremy, Goldar, Arach, Hyrien, Olivier, Audit, Benjamin

“…In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S…”
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Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones by Kirstein, Nina, Buschle, Alexander, Wu, Xia, Krebs, Stefan, Blum, Helmut, Kremmer, Elisabeth, Vorberg, Ina M, Hammerschmidt, Wolfgang, Lacroix, Laurent, Hyrien, Olivier, Audit, Benjamin, Schepers, Aloys

“…Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the…”
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FORK-seq: replication landscape of the Saccharomyces cerevisiae genome by nanopore sequencing by Hennion, Magali, Arbona, Jean-Michel, Lacroix, Laurent, Cruaud, Corinne, Theulot, Bertrand, Tallec, Benoît Le, Proux, Florence, Wu, Xia, Novikova, Elizaveta, Engelen, Stefan, Lemainque, Arnaud, Audit, Benjamin, Hyrien, Olivier

“…Genome replication mapping methods profile cell populations, masking cell-to-cell heterogeneity. Here, we describe FORK-seq, a nanopore sequencing method to…”
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Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers by DeWeerd, Rachel A., Németh, Eszter, Póti, Ádám, Petryk, Nataliya, Chen, Chun-Long, Hyrien, Olivier, Szüts, Dávid, Green, Abby M.

“…Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy…”
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Genome-wide mapping of individual replication fork velocities using nanopore sequencing by Theulot, Bertrand, Lacroix, Laurent, Arbona, Jean-Michel, Millot, Gael A., Jean, Etienne, Cruaud, Corinne, Pellet, Jade, Proux, Florence, Hennion, Magali, Engelen, Stefan, Lemainque, Arnaud, Audit, Benjamin, Hyrien, Olivier, Le Tallec, Benoît

“…Little is known about replication fork velocity variations along eukaryotic genomes, since reference techniques to determine fork speed either provide no…”
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Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes by Chen, Chun-Long, Rappailles, Aurélien, Duquenne, Lauranne, Huvet, Maxime, Guilbaud, Guillaume, Farinelli, Laurent, Audit, Benjamin, d'Aubenton-Carafa, Yves, Arneodo, Alain, Hyrien, Olivier, Thermes, Claude

“…Neutral nucleotide substitutions occur at varying rates along genomes, and it remains a major issue to unravel the mechanisms that cause these variations and…”
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The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation by Arbona, Jean-Michel, Goldar, Arach, Hyrien, Olivier, Arneodo, Alain, Audit, Benjamin

“…The time-dependent rate [Formula: see text] of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been…”
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Evidence for sequential and increasing activation of replication origins along replication timing gradients in the human genome by Guilbaud, Guillaume, Rappailles, Aurélien, Baker, Antoine, Chen, Chun-Long, Arneodo, Alain, Goldar, Arach, d'Aubenton-Carafa, Yves, Thermes, Claude, Audit, Benjamin, Hyrien, Olivier

“…Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by…”
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Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress by Srinivasan, Seetha V., Dominguez-Sola, David, Wang, Lily C., Hyrien, Olivier, Gautier, Jean

“…c-Myc oncogenic activity is thought to be mediated in part by its ability to generate DNA replication stress and subsequent genomic instability when…”
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ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells by Despras, Emmanuelle, Daboussi, Fayza, Hyrien, Olivier, Marheineke, Kathrin, Kannouche, Patricia L.

“…DNA polymerase eta (polη) performs translesion synthesis past ultraviolet (UV) photoproducts and is deficient in cancer-prone xeroderma pigmentosum variant…”
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Replication fork polarity gradients revealed by megabase-sized U-shaped replication timing domains in human cell lines by Baker, Antoine, Audit, Benjamin, Chen, Chun-Long, Moindrot, Benoit, Leleu, Antoine, Guilbaud, Guillaume, Rappailles, Aurélien, Vaillant, Cédric, Goldar, Arach, Mongelard, Fabien, d'Aubenton-Carafa, Yves, Hyrien, Olivier, Thermes, Claude, Arneodo, Alain

“…In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about…”
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Universal temporal profile of replication origin activation in eukaryotes by Goldar, Arach, Marsolier-Kergoat, Marie-Claude, Hyrien, Olivier

“…Although replication proteins are conserved among eukaryotes, the sequence requirements for replication initiation differ between species. In all species,…”
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Y RNA functions at the initiation step of mammalian chromosomal DNA replication by Krude, Torsten, Christov, Christo P, Hyrien, Olivier, Marheineke, Kathrin

“…Non-coding Y RNAs have recently been identified as essential novel factors for chromosomal DNA replication in mammalian cell nuclei, but mechanistic details of…”
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Paradoxes of eukaryotic DNA replication: MCM proteins and the random completion problem by Hyrien, Olivier, Marheineke, Kathrin, Goldar, Arach

“…Eukaryotic DNA replication initiates at multiple origins. In early fly and frog embryos, chromosomal replication is very rapid and initiates without sequence…”
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A dynamic stochastic model for DNA replication initiation in early embryos by Goldar, Arach, Labit, Hélène, Marheineke, Kathrin, Hyrien, Olivier

“…Eukaryotic cells seem unable to monitor replication completion during normal S phase, yet must ensure a reliable replication completion time. This is an acute…”
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From Simple Bacterial and Archaeal Replicons to Replication N/U-Domains by Hyrien, Olivier, Rappailles, Aurélien, Guilbaud, Guillaume, Baker, Antoine, Chen, Chun-Long, Goldar, Arach, Petryk, Nataliya, Kahli, Malik, Ma, Emilie, d'Aubenton-Carafa, Yves, Audit, Benjamin, Thermes, Claude, Arneodo, Alain

“…The Replicon Theory proposed 50years ago has proven to apply for replicons of the three domains of life. Here, we review our knowledge of genome organization…”
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