Search Results - "Hypolite, Guillaume"

DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia by Bond, Jonathan, Touzart, Aurore, Leprêtre, Stéphane, Graux, Carlos, Bargetzi, Mario, Lhermitte, Ludovic, Hypolite, Guillaume, Leguay, Thibaut, Hicheri, Yosr, Guillerm, Gaëlle, Bilger, Karin, Lhéritier, Véronique, Hunault, Mathilde, Huguet, Françoise, Chalandon, Yves, Ifrah, Norbert, Macintyre, Elizabeth, Dombret, Hervé, Asnafi, Vahid, Boissel, Nicolas

“…The prognostic implications of genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and…”
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A transcriptomic continuum of differentiation arrest identifies myeloid interface acute leukemias with poor prognosis by Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander Abdulkader, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Castaigne, Sylvie, Boissel, Nicolas, Asnafi, Vahid, Preudhomme, Claude, Dombret, Hervé, Laurenti, Elisa, Macintyre, Elizabeth

“…Classification of acute lymphoblastic and myeloid leukemias (ALL and AML) remains heavily based on phenotypic resemblance to normal hematopoietic precursors…”
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Harnessing the MYB-dependent TAL1 5'super-enhancer for targeted therapy in T-ALL by Smith, Charlotte, Touzart, Aurore, Simonin, Mathieu, Tran-Quang, Christine, Hypolite, Guillaume, Latiri, Mehdi, Andrieu, Guillaume P, Balducci, Estelle, Dourthe, Marie-Émilie, Goyal, Ashish, Huguet, Françoise, Petit, Arnaud, Ifrah, Norbert, Baruchel, André, Dombret, Hervé, Macintyre, Elizabeth, Plass, Christoph, Ghysdael, Jacques, Boissel, Nicolas, Asnafi, Vahid

“…The acquisition of genetic abnormalities engendering oncogene dysregulation underpins cancer development. Certain proto-oncogenes possess several dysregulation…”
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CBFβ-SMMHC Affects Genome-wide Polycomb Repressive Complex 1 Activity in Acute Myeloid Leukemia by Cordonnier, Gaëlle, Mandoli, Amit, Cagnard, Nicolas, Hypolite, Guillaume, Lhermitte, Ludovic, Verhoeyen, Els, Asnafi, Vahid, Dillon, Niall, Macintyre, Elizabeth, Martens, Joost H.A., Bond, Jonathan

“…Mutations and deletions of polycomb repressive complex (PRC) components are increasingly recognized to affect tumor biology in a range of cancers. However,…”
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Novel Intergenically Spliced Chimera, NFATC3-PLA2G15 , Is Associated with Aggressive T-ALL Biology and Outcome by Bond, Jonathan, Tran Quang, Christine, Hypolite, Guillaume, Belhocine, Mohamed, Bergon, Aurélie, Cordonnier, Gaëlle, Ghysdael, Jacques, Macintyre, Elizabeth, Boissel, Nicolas, Spicuglia, Salvatore, Asnafi, Vahid

“…Leukemias are frequently characterized by the expression of oncogenic fusion chimeras that normally arise due to chromosomal rearrangements. Intergenically…”
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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer by Lenos, Kristiaan J., Miedema, Daniël M., Lodestijn, Sophie C., Nijman, Lisanne E., van den Bosch, Tom, Romero Ros, Xavier, Lourenço, Filipe C., Lecca, Maria C., van der Heijden, Maartje, van Neerven, Sanne M., van Oort, Anita, Leveille, Nicolas, Adam, Ronja S., de Sousa E Melo, Felipe, Otten, Joy, Veerman, Patrick, Hypolite, Guillaume, Koens, Lianne, Lyons, Scott K., Stassi, Giorgio, Winton, Douglas J., Medema, Jan Paul, Morrissey, Edward, Bijlsma, Maarten F., Vermeulen, Louis

“…Solid malignancies have been speculated to depend on cancer stem cells (CSCs) for expansion and relapse after therapy. Here we report on quantitative analyses…”
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Prognostic value and oncogenic landscape of TP53 alterations in adult and pediatric T-ALL by Simonin, Mathieu, Andrieu, Guillaume P., Birsen, Rudy, Balsat, Marie, Hypolite, Guillaume, Courtois, Lucien, Graux, Carlos, Grardel, Nathalie, Cayuela, Jean-Michel, Huguet, Françoise, Chalandon, Yves, Le Bris, Yannick, Macintyre, Elizabeth, Gandemer, Virginie, Petit, Arnaud, Rousselot, Philippe, Baruchel, André, Bouscary, Didier, Hermine, Olivier, Boissel, Nicolas, Asnafi, Vahid

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Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation by Cieslak, Agata, Charbonnier, Guillaume, Tesio, Melania, Mathieu, Eve-Lyne, Belhocine, Mohamed, Touzart, Aurore, Smith, Charlotte, Hypolite, Guillaume, Andrieu, Guillaume P, Martens, Joost H A, Janssen-Megens, Eva, Gut, Marta, Gut, Ivo, Boissel, Nicolas, Petit, Arnaud, Puthier, Denis, Macintyre, Elizabeth, Stunnenberg, Hendrik G, Spicuglia, Salvatore, Asnafi, Vahid

“…Cell differentiation is accompanied by epigenetic changes leading to precise lineage definition and cell identity. Here we present a comprehensive resource of…”
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A Transcriptomic Continuum of Differentiation Arrest in Acute Leukemia by Bond, Jonathan, Krzywon, Aleksandra, Lhermitte, Ludovic, Roumier, Christophe, Roggy, Anne, Belhocine, Mohamed, Kheirallah, Alexander, Villarese, Patrick, Hypolite, Guillaume, Garnache-Ottou, Francine, Dombret, Herve, Boissel, Nicolas, Preudhomme, Claude, Asnafi, Vahid, Laurenti, Elisa, Macintyre, Elizabeth

“…Introduction: Traditional classification of acute lymphoblastic and myeloid leukemias (ALLs and AMLs) remains heavily based on phenotypic resemblance to normal…”
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ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development by Andrieu, Guillaume P., Hypolite, Guillaume, Latiri, Mehdi, Balducci, Estelle, Costa, Caroline, Verhoeyen, Els, Courgeon, Marianne, Allatif, Omran, Nemazanyy, Ivan, Panasyuk, Ganna, Wellen, Kathryn E, Herranz, Daniel, Genestier, Laurent, Macintyre, Elizabeth A., Asnafi, Vahid, Tesio, Melania

“…Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematological cancers, such as T-cell acute lymphoblastic leukemia…”
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Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia by Bond, Jonathan, Labis, Elise, Marceau-Renaut, Alice, Duployez, Nicolas, Labopin, Myriam, Hypolite, Guillaume, Michel, Gérard, Ducassou, Stéphane, Boutroux, Hélène, Nelken, Brigitte, Bertrand, Yves, Baruchel, André, Petit, Arnaud, Asnafi, Vahid, Leverger, Guy, Preudhomme, Claude, Macintyre, Elizabeth, Lapillonne, Hélène

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DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia by Bond, Jonathan, Touzart, Aurore, Leprêtre, Stéphane, Graux, Carlos, Bargetzi, Mario, Lhermitte, Ludovic, Hypolite, Guillaume, Leguay, Thibaut, Hicheri, Yosr, Guillerm, Gaelle, Bilger, Karin, Lheritier, Véronique, Hunault-Berger, Mathilde, Huguet, Francoise, Chalandon, Yves, Ifrah, Norbert, Macintyre, Elizabeth, Dombret, Hervé, Asnafi, Vahid, Boissel, Nicolas

“…The prognostic implications of DNMT3A genotype in T-ALL are incompletely understood. We performed comprehensive genetic and clinicobiological analyses of T-ALL…”
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