Search Results - "Hynes, NE"

ERBB receptors and cancer: the complexity of targeted inhibitors by Hynes, Nancy E, Lane, Heidi A

“…ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2…”
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ErbB Receptors: Directing key signaling networks throughout life by HOLBRO, Thomas, HYNES, Nancy E

“…The epidermal growth factor (EGF)-related peptides bind the ErbB receptors, inducing the formation of different homo- and heterodimers. Receptor dimerization…”
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The ErbB receptors and their role in cancer progression by Holbro, Thomas, Civenni, Gianluca, Hynes, Nancy E

“…The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in a variety of physiological events during normal…”
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The ErbB2/ErbB3 Heterodimer Functions as an Oncogenic Unit: ErbB2 Requires ErbB3 to Drive Breast Tumor Cell Proliferation by Holbro, Thomas, Beerli, Roger R., Maurer, Francisca, Koziczak, Magdalena, Barbas, Carlos F., Hynes, Nancy E.

“…ErbB2 is a receptor tyrosine kinase whose activity in normal cells depends on dimerization with another ligand-binding ErbB receptor. In contrast,…”
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The ErbB signaling network: receptor heterodimerization in development and cancer by Olayioye, Monilola A., Neve, Richard M., Lane, Heidi A., Hynes, Nancy E.

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Abstract PD01-06: Inhibition of the Ret receptor tyrosine kinase in combination with endocrine therapy impacts on migration and metastatic potential of estrogen receptor positive breast cancer models by Hynes, NE, Gattelli, A, Nalvarte, I, Roloff, T

“…The Ret receptor tyrosine kinase is overexpressed in approximately 30% of human breast cancers, many of which are estrogen receptor-alpha positive (ER+). Using…”
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Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters by Moor, Matthias B, Haenzi, Barbara, Legrand, Finola, Koesters, Robert, Hynes, Nancy E, Bonny, Olivier

“…Ablation of the Mediator of ErbB2-driven Cell Motility 1 (Memo1) in mice altered calcium homeostasis and renal calcium transporter abundance by an unknown…”
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Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization by Frei, Anna, MacDonald, Gwen, Lund, Ingrid, Gustafsson, Jan-Åke, Hynes, Nancy E, Nalvarte, Ivan

“…Understanding the complex interaction between growth factor and steroid hormone signaling pathways in breast cancer is key to identifying suitable therapeutic…”
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The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides by MOTOYAMA, Andrea B, HYNES, Nancy E, LANE, Heidi A

“…The ErbB1 and ErbB2 receptor tyrosine kinases (RTKs) play important roles in the development of numerous types of human cancer and, as such, have been pursued…”
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Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins by KOZICZAK, Magdalena, HOLBRO, Thomas, HYNES, Nancy E

“…Overexpression of fibroblast growth factor receptor (FGFR) tyrosine kinases has been found in many human breast cancers and has been associated with poor…”
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The biology of erbB-2/neu/HER-2 and its role in cancer by Hynes, N E, Stern, D F

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Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells by BADACHE, Ali, HYNES, Nancy E

“…Interleukin (IL)-6, a multifunctional regulator of immune response, hematopoiesis, and acute phase reactions, has also been shown to regulate cancer cell…”
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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling by Graus-Porta, Diana, Beerli, Roger R., Daly, John M., Hynes, Nancy E.

“…We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)‐related peptides in cell lines naturally expressing the four ErbB…”
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Memo mediates ErbB2-driven cell motility by Hynes, Nancy E, Marone, Romina, Hess, Daniel, Dankort, David, Muller, William J, Badache, Ali

“…Clinical studies have revealed that cancer patients whose tumours have increased ErbB2 expression tend to have more aggressive, metastatic disease, which is…”
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Cooperation between Fibroblast Growth Factor Receptor-4 and ErbB2 in Regulation of Cyclin D1 Translation by Koziczak, Magdalena, Hynes, Nancy E.

“…Alterations in ErbB2 or fibroblast growth factor receptor-4 (FGFR-4) expression and activity occur in a significant fraction of breast cancers. Because…”
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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency by Lane, H A, Beuvink, I, Motoyama, A B, Daly, J M, Neve, R M, Hynes, N E

“…Overexpression of the ErbB2 receptor, a major component of the ErbB receptor signaling network, contributes to the development of a number of human cancers…”
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Wnt1 and Wnt5a induce cyclin D1 expression through ErbB1 transactivation in HC11 mammary epithelial cells by Civenni, Gianluca, Holbro, Thomas, Hynes, Nancy E

“…Constitutive expression of Wnt1 and Wnt5a in HC11 mammary cells led to elevated TCF transcriptional activity. Intriguingly, Wnt‐expressing cells also displayed…”
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A new therapeutic antibody masks ErbB2 to its partners by Badache, Ali, Hynes, Nancy E

“…In cancer cells, the ErbB2 receptor tyrosine kinase can be activated in two ways: by overexpression or by ligand-mediated stimulation of another ErbB receptor…”
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The ErbB-2/HER2 Oncoprotein of Human Carcinomas May Function Solely as a Shared Coreceptor for Multiple Stroma-Derived Growth Factors by Klapper, Leah N., Glathe, Stefanie, Vaisman, Nora, Hynes, Nancy E., Andrews, Glenn C., Sela, Michael, Yarden, Yosef

“…The erbB-2/HER2 oncogene is overexpressed in a significant fraction of human carcinomas of the breast, ovary, and lung in a manner that correlates with poor…”
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ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases by Olayioye, M A, Beuvink, I, Horsch, K, Daly, J M, Hynes, N E

“…Epidermal growth factor (EGF) binding to its receptor, ErbB1, triggers various signal transduction pathways, one of which leads to the activation of signal…”
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