Search Results - "Hyman, Bradley T."

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease by Spires-Jones, Tara L., Hyman, Bradley T.

“…The collapse of neural networks important for memory and cognition, including death of neurons and degeneration of synapses, causes the debilitating dementia…”
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Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis by Henstridge, Christopher M., Hyman, Bradley T., Spires-Jones, Tara L.

“…The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but neurons do not work in isolation. Emerging evidence suggests…”
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Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology by Hyman, Bradley T., Yuan, Junying

“…Key Points Caspases are an integral mediator of programmed cell death during development in the CNS, although experiments using mice deficient in various…”
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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease by de Calignon, Alix, Polydoro, Manuela, Suárez-Calvet, Marc, William, Christopher, Adamowicz, David H., Kopeikina, Kathy J., Pitstick, Rose, Sahara, Naruhiko, Ashe, Karen H., Carlson, George A., Spires-Jones, Tara L., Hyman, Bradley T.

“…Neurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic and association cortices as Alzheimer's disease evolves. However,…”
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Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease by Bennett, Rachel E., Robbins, Ashley B., Hu, Miwei, Cao, Xinrui, Betensky, Rebecca A., Clark, Tim, Das, Sudeshna, Hyman, Bradley T.

“…Mixed pathology, with both Alzheimer’s disease and vascular abnormalities, is the most common cause of clinical dementia in the elderly. While usually thought…”
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APOE4 derived from astrocytes leads to blood-brain barrier impairment by Jackson, Rosemary J, Meltzer, Jonah C, Nguyen, Huong, Commins, Caitlin, Bennett, Rachel E, Hudry, Eloise, Hyman, Bradley T

“…Apolipoprotein E (ApoE) is a multifaceted secreted molecule synthesized in the CNS by astrocytes and microglia, and in the periphery largely by the liver. ApoE…”
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Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains by Gui, Yaxing, Marks, Jordan D., Das, Sudeshna, Hyman, Bradley T., Serrano‐Pozo, Alberto

“…The 18 kDa translocator protein (TSPO) is a widely used target for microglial PET imaging radioligands, but its expression in post‐mortem normal and diseased…”
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Machine learning identifies candidates for drug repurposing in Alzheimer’s disease by Rodriguez, Steve, Hug, Clemens, Todorov, Petar, Moret, Nienke, Boswell, Sarah A., Evans, Kyle, Zhou, George, Johnson, Nathan T., Hyman, Bradley T., Sorger, Peter K., Albers, Mark W., Sokolov, Artem

“…Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a large amount of time and resources with largely negative results…”
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Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration by Noori, Ayush, Mezlini, Aziz M., Hyman, Bradley T., Serrano-Pozo, Alberto, Das, Sudeshna

“…Neurodegenerative disorders such as Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia…”
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The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease by Hopp, Sarah C, Lin, Yang, Oakley, Derek, Roe, Allyson D, DeVos, Sarah L, Hanlon, David, Hyman, Bradley T

“…Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer's disease…”
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Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration by Das, Sudeshna, Li, Zhaozhi, Noori, Ayush, Hyman, Bradley T, Serrano-Pozo, Alberto

“…Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans…”
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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase by Hernández-Vega, Amayra, Braun, Marcus, Scharrel, Lara, Jahnel, Marcus, Wegmann, Susanne, Hyman, Bradley T., Alberti, Simon, Diez, Stefan, Hyman, Anthony A.

“…Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle…”
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Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes by Chung, Won-Suk, Verghese, Philip B., Chakraborty, Chandrani, Joung, Julia, Hyman, Bradley T., Ulrich, Jason D., Holtzman, David M., Barres, Ben A.

“…The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer’s disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common…”
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Poor Performance on a Preoperative Cognitive Screening Test Predicts Postoperative Complications in Older Orthopedic Surgical Patients by Culley, Deborah J, Flaherty, Devon, Fahey, Margaret C, Rudolph, James L, Javedan, Houman, Huang, Chuan-Chin, Wright, John, Bader, Angela M, Hyman, Bradley T, Blacker, Deborah, Crosby, Gregory

“…BACKGROUND:The American College of Surgeons and the American Geriatrics Society have suggested that preoperative cognitive screening should be performed in…”
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Tau Propagation, Different Tau Phenotypes, and Prion-like Properties of Tau by Hyman, Bradley T.

“…Sanders et al. (2014) demonstrate in this issue of Neuron that the natively unfolded protein tau can propagate indefinitely in distinct stable strains,…”
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Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism by Cooper, Joanna M., Lathuiliere, Aurelien, Migliorini, Mary, Arai, Allison L., Wani, Mashhood M., Dujardin, Simon, Muratoglu, Selen C., Hyman, Bradley T., Strickland, Dudley K.

“…In Alzheimer's disease (AD), pathological forms of tau are transferred from cell to cell and “seed” aggregation of cytoplasmic tau. Phosphorylation of tau…”
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Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue by Marquié, Marta, Normandin, Marc D., Vanderburg, Charles R., Costantino, Isabel M., Bien, Elizabeth A., Rycyna, Lisa G., Klunk, William E., Mathis, Chester A., Ikonomovic, Milos D., Debnath, Manik L., Vasdev, Neil, Dickerson, Bradford C., Gomperts, Stephen N., Growdon, John H., Johnson, Keith A., Frosch, Matthew P., Hyman, Bradley T., Gómez-Isla, Teresa

“…Objective To examine region‐ and substrate‐specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F‐18]‐AV‐1451…”
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Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice by Kuchibhotla, Kishore V, Lattarulo, Carli R, Hyman, Bradley T, Bacskai, Brian J

“…Although senile plaques focally disrupt neuronal health, the functional response of astrocytes to Alzheimer's disease pathology is unknown. Using multiphoton…”
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Oxidative stress and lipid peroxidation are upstream of amyloid pathology by Arimon, Muriel, Takeda, Shuko, Post, Kathryn L, Svirsky, Sarah, Hyman, Bradley T, Berezovska, Oksana

“…Abstract Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the…”
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice by Caballero, Benjamin, Bourdenx, Mathieu, Luengo, Enrique, Diaz, Antonio, Sohn, Peter Dongmin, Chen, Xu, Wang, Chao, Juste, Yves R., Wegmann, Susanne, Patel, Bindi, Young, Zapporah T., Kuo, Szu Yu, Rodriguez-Navarro, Jose Antonio, Shao, Hao, Lopez, Manuela G., Karch, Celeste M., Goate, Alison M., Gestwicki, Jason E., Hyman, Bradley T., Gan, Li, Cuervo, Ana Maria

“…Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of neurodegenerative disorders known as tauopathies. Acetylation of…”
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