Search Results - "Hyman, B T"

Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model by Garcia‐Alloza, M., Borrelli, L. A., Rozkalne, A., Hyman, B. T., Bacskai, B. J.

“…Alzheimer’s disease (AD) is characterized by senile plaques and neurodegeneration although the neurotoxic mechanisms have not been completely elucidated. It is…”
Get full text

MRI measures of entorhinal cortex vs hippocampus in preclinical AD by KILLIANY, R. J, HYMAN, B. T, GOMEZ-ISLA, T, MOSS, M. B, KIKINIS, R, JOLESZ, F, TANZI, R, JONES, K, ALBERT, M. S

“…MRI measures of the entorhinal cortex and the hippocampus have been used to predict which nondemented individuals with memory problems will progress to meet…”
Get full text

MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD by DESIKAN, R. S, FISCHL, B, CABRAL, H. J, KEMPER, T. L, GUTTMANN, C. R. G, BLACKER, D, HYMAN, B. T, ALBERT, M. S, KILLIANY, R. J

“…MRI studies have demonstrated differential rates of atrophy in the entorhinal cortex and hippocampus during the prodromal phase of Alzheimer disease (AD). The…”
Get full text

Imaging amyloid deposition in Lewy body diseases by GOMPERTS, S. N, RENTZ, D. M, HYMAN, B. T, GROWDON, J. H, JOHNSON, K. A, MORAN, E, BECKER, J. A, LOCASCIO, J. J, KLUNK, W. E, MATHIS, C. A, ELMALEH, D. R, SHOUP, T, FISCHMAN, A. J

Get full text

Association of homocysteine with plasma amyloid β protein in aging and neurodegenerative disease by IRIZARRY, M. C, GUROL, M. E, RAJU, S, DIAZ-ARRASTIA, R, LOCASCIO, J. J, TENNIS, M, HYMAN, B. T, GROWDON, J. H, GREENBERG, S. M, BOTTIGLIERI, T

“…Elevated plasma total homocysteine (tHcy) is a risk factor for cardiovascular disease and is reported to be an independent risk factor for Alzheimer disease…”
Get full text

Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice by Beglopoulos, V., Tulloch, J., Roe, A. D., Daumas, S., Ferrington, L., Watson, R., Fan, Z., Hyman, B. T., Kelly, P. A. T., Bard, F., Morris, R. G. M.

“…Earlier diagnosis and treatment of Alzheimer’s disease would greatly benefit from the identification of biomarkers at the prodromal stage. Using a prominent…”
Get full text

Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain by INGELSSON, M, FUKUMOTO, H, NEWELL, K. L, GROWDON, J. H, HEDLEY-WHYTE, E. T, FROSCH, M. P, ALBERT, M. S, HYMAN, B. T, IRIZARRY, M. C

Get full text

α-Synuclein–enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons by McLean, P.J, Kawamata, H, Hyman, B.T

“…α-Synuclein accumulates in the brains of sporadic Parkinson’s disease patients as a major component of Lewy bodies, and mutations in α-synuclein are associated…”
Get full text

Neurotoxic Effects of Thioflavin S-Positive Amyloid Deposits in Transgenic Mice and Alzheimer's Disease by Urbanc, B., Cruz, L., Le, R., Sanders, J., Ashe, K. Hsiao, Duff, K., Stanley, H. E., Irizarry, M. C., Hyman, B. T.

“…Despite extensive deposition of putatively neurotoxic amyloid-β(Aβ) protein in the brain, it has not been possible to demonstrate an association of Aβ deposits…”
Get full text

Temporoparietal MR Imaging Measures of Atrophy in Subjects with Mild Cognitive Impairment That Predict Subsequent Diagnosis of Alzheimer Disease by Desikan, R.S, Cabral, H.J, Fischl, B, Guttmann, C.R.G, Blacker, D, Hyman, B.T, Albert, M.S, Killiany, R.J

“…Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific…”
Get full text

Serum cystatin C and the risk of Alzheimer disease in elderly men by Sundelöf, J, Arnlöv, J, Ingelsson, E, Sundström, J, Basu, S, Zethelius, B, Larsson, A, Irizarry, M C, Giedraitis, V, Rönnemaa, E, Degerman-Gunnarsson, M, Hyman, B T, Basun, H, Kilander, L, Lannfelt, L

“…Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD). Serum cystatin C…”
Get full text

Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain by Broekman, M.L.D., Comer, L.A., Hyman, B.T., Sena-Esteves, M.

“…Adeno-associated virus (AAV) vectors have gained a preeminent position in the field of gene delivery to the normal brain through their ability to achieve…”
Get full text

The Endocytic Receptor Protein LRP Also Mediates Neuronal Calcium Signaling via N-methyl-D-aspartate Receptors by Bacskai, B. J., Xia, M. Q., Strickland, D. K., Rebeck, G. W., Hyman, B. T.

“…The low density lipoprotein receptor-related protein (LRP) is an endocytic receptor that is a member of the low density lipoprotein receptor family. We report…”
Get full text

Plasma Aβ, homocysteine, and cognition : The Vitamin Intervention for Stroke Prevention (VISP) trial by VISWANATHAN, A, RAJ, S, GREENBERG, S. M, STAMPFER, M, CAMPBELL, S, HYMAN, B. T, IRIZARRY, M. C

“…Background: Amyloid-beta protein (A beta ) plays a key role in Alzheimer disease (AD) and is also implicated in cerebral small vessel disease. Serum total…”
Get full text

Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations by CATALDO, A. M, PETERHOFF, C. M, TRONCOSO, J. C, GOMEZ-ISLA, T, HYMAN, B. T, NIXON, R. A

“…Endocytosis is critical to the function and fate of molecules important to Alzheimer's disease (AD) etiology, including the beta protein precursor (betaPP),…”
Get full text

Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy by Christie, R. H, Bacskai, B. J, Zipfel, W. R, Williams, R. M, Kajdasz, S. T, Webb, W. W, Hyman, B. T

“…In Alzheimer's disease, amyloid-beta peptide aggregates in the extracellular space to form senile plaques. The process of plaque deposition and growth has been…”
Get full text

Application of the National Institute on Aging (NIA)-Reagan Institute Criteria for the Neuropathological Diagnosis of Alzheimer Disease by Newell, Kathy L, Hyman, Bradley T, Growdon, John H, Hedley-Whyte, E Tessa

“…The Khachaturian criteria and the Consortium to Establish a Registry for Alzheimer Disease (CERAD) criteria for the neuropathological assessment of Alzheimer…”
Get full text

ApoE isoforms affect neuronal N-methyl- d-aspartate calcium responses and toxicity via receptor-mediated processes by Qiu, Z, Crutcher, K.A, Hyman, B.T, Rebeck, G.W

“…Apolipoprotein E (apoE) alters the pathophysiology of Alzheimer's disease, but its mechanism is not fully understood. We examined the effects of recombinant…”
Get full text

α-Synuclein immunoreactivity in dementia with Lewy bodies : morphological staging and comparison with ubiquitin immunostaining by GOMEZ-TORTOSA, E, NEWELL, K, IRIZARRY, M. C, SANDERS, J. L, HYMAN, B. T

“…alpha-Synuclein is a presynaptic protein recently identified as a specific component of Lewy bodies (LB) and Lewy neurites. The aim of this study was to assess…”
Get full text

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease by Gómez-Isla, T, Hollister, R, West, H, Mui, S, Growdon, J H, Petersen, R C, Parisi, J E, Hyman, B T

“…To assess the relationship between dementia, neuronal loss, and neuropathological findings in Alzheimer's disease (AD), we counted the number of neurons,…”
Get more information