Search Results - "Hyman, A. A"

Phase separation provides a mechanism to reduce noise in cells by Klosin, A, Oltsch, F, Harmon, T, Honigmann, A, Jülicher, F, Hyman, A A, Zechner, C

“…Expression of proteins inside cells is noisy, causing variability in protein concentration among identical cells. A central problem in cellular control is how…”
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Are aberrant phase transitions a driver of cellular aging? by Alberti, Simon, Hyman, Anthony A.

“…Why do cells age? Recent advances show that the cytoplasm is organized into many membrane‐less compartments via a process known as phase separation, which…”
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Liquid-Liquid Phase Separation in Biology by Hyman, Anthony A, Weber, Christoph A, Jülicher, Frank

“…Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that…”
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ATP as a biological hydrotrope by Patel, Avinash, Malinovska, Liliana, Saha, Shambaditya, Wang, Jie, Alberti, Simon, Krishnan, Yamuna, Hyman, Anthony A.

“…Hydrotropes are small molecules that solubilize hydrophobic molecules in aqueous solutions. Typically, hydrotropes are amphiphilic molecules and differ from…”
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The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin by Woodruff, Jeffrey B., Ferreira Gomes, Beatriz, Widlund, Per O., Mahamid, Julia, Honigmann, Alf, Hyman, Anthony A.

“…Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays. They consist of nanometer-scale centrioles surrounded by a micron-scale,…”
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Controlling compartmentalization by non-membrane-bound organelles by Wheeler, Richard J., Hyman, Anthony A.

“…Compartmentalization is a characterizing feature of complexity in cells, used to organize their biochemistry. Membrane-bound organelles are most widely known,…”
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Beyond Oil and Water—Phase Transitions in Cells by Hyman, Anthony A., Simons, Kai

“…The organization of cellular compartments may be driven by liquid phase separations and the collective low-affinity interactions of macromolecules…”
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Growth and division of active droplets provides a model for protocells by Zwicker, David, Seyboldt, Rabea, Weber, Christoph A., Hyman, Anthony A., Jülicher, Frank

“…It has been proposed that during the early steps in the origin of life, small droplets could have formed via the segregation of molecules from complex mixtures…”
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A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances by Hein, Marco Y., Hubner, Nina C., Poser, Ina, Cox, Jürgen, Nagaraj, Nagarjuna, Toyoda, Yusuke, Gak, Igor A., Weisswange, Ina, Mansfeld, Jörg, Buchholz, Frank, Hyman, Anthony A., Mann, Matthias

“…The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the…”
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Organization and Function of Non-dynamic Biomolecular Condensates by Woodruff, Jeffrey B., Hyman, Anthony A., Boke, Elvan

“…Cells compartmentalize biochemical reactions using organelles. Organelles can be either membrane-bound compartments or supramolecular assemblies of protein and…”
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Protein condensates as aging Maxwell fluids by Jawerth, Louise, Fischer-Friedrich, Elisabeth, Saha, Suropriya, Wang, Jie, Franzmann, Titus, Zhang, Xiaojie, Sachweh, Jenny, Ruer, Martine, Ijavi, Mahdiye, Saha, Shambaditya, Mahamid, Julia, Hyman, Anthony A, Jülicher, Frank

“…Protein condensates are complex fluids that can change their material properties with time. However, an appropriate rheological description of these fluids…”
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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins by Wang, Jie, Choi, Jeong-Mo, Holehouse, Alex S., Lee, Hyun O., Zhang, Xiaojie, Jahnel, Marcus, Maharana, Shovamayee, Lemaitre, Régis, Pozniakovsky, Andrei, Drechsel, David, Poser, Ina, Pappu, Rohit V., Alberti, Simon, Hyman, Anthony A.

“…Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the…”
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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation by Patel, Avinash, Lee, Hyun O., Jawerth, Louise, Maharana, Shovamayee, Jahnel, Marcus, Hein, Marco Y., Stoynov, Stoyno, Mahamid, Julia, Saha, Shambaditya, Franzmann, Titus M., Pozniakovski, Andrej, Poser, Ina, Maghelli, Nicola, Royer, Loic A., Weigert, Martin, Myers, Eugene W., Grill, Stephan, Drechsel, David, Hyman, Anthony A., Alberti, Simon

“…Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study…”
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Organelle Growth Control through Limiting Pools of Cytoplasmic Components by Goehring, Nathan W., Hyman, Anthony A.

“…The critical importance of controlling the size and number of intracellular organelles has led to a variety of mechanisms for regulating the formation and…”
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Phase separation of a yeast prion protein promotes cellular fitness by Franzmann, Titus M, Jahnel, Marcus, Pozniakovsky, Andrei, Mahamid, Julia, Holehouse, Alex S, Nüske, Elisabeth, Richter, Doris, Baumeister, Wolfgang, Grill, Stephan W, Pappu, Rohit V, Hyman, Anthony A, Alberti, Simon

“…Despite the important role of prion domains in neurodegenerative disease, their physiological function has remained enigmatic. Previous work with yeast prions…”
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Centrosomes are autocatalytic droplets of pericentriolar material organized by centrioles by Zwicker, David, Decker, Markus, Jaensch, Steffen, Hyman, Anthony A, Jülicher, Frank

“…Centrosomes are highly dynamic, spherical organelles without a membrane. Their physical nature and their assembly are not understood. Using the concept of…”
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RNA buffers the phase separation behavior of prion-like RNA binding proteins by Maharana, Shovamayee, Wang, Jie, Papadopoulos, Dimitrios K, Richter, Doris, Pozniakovsky, Andrey, Poser, Ina, Bickle, Marc, Rizk, Sandra, Guillén-Boixet, Jordina, Franzmann, Titus M, Jahnel, Marcus, Marrone, Lara, Chang, Young-Tae, Sterneckert, Jared, Tomancak, Pavel, Hyman, Anthony A, Alberti, Simon

“…Prion-like RNA binding proteins (RBPs) such as TDP43 and FUS are largely soluble in the nucleus but form solid pathological aggregates when mislocalized to the…”
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Pericentriolar material structure and dynamics by Woodruff, Jeffrey B., Wueseke, Oliver, Hyman, Anthony A.

“…A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform…”
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Ki-67 acts as a biological surfactant to disperse mitotic chromosomes by Cuylen, Sara, Blaukopf, Claudia, Politi, Antonio Z., Müller-Reichert, Thomas, Neumann, Beate, Poser, Ina, Ellenberg, Jan, Hyman, Anthony A., Gerlich, Daniel W.

“…During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has…”
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Visualizing the molecular sociology at the HeLa cell nuclear periphery by Mahamid, Julia, Pfeffer, Stefan, Schaffer, Miroslava, Villa, Elizabeth, Danev, Radostin, Cuellar, Luis Kuhn, Förster, Friedrich, Hyman, Anthony A., Plitzko, Jürgen M., Baumeister, Wolfgang

“…The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here we combined recent developments in cryo–electron tomography (cryo-ET)…”
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