Search Results - "Hylkema, Machteld"

Differential DNA methylation in newborns with maternal exposure to heavy metals from an e-waste recycling area by Zeng, Zhijun, Huo, Xia, Zhang, Yu, Hylkema, Machteld N., Wu, Yousheng, Xu, Xijin

“…This study explored the effects of maternal exposure to e-waste environmental heavy metals on neonatal DNA methylation patterns. Neonatal umbilical cord blood…”
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Association between 6PPD-quinone exposure and BMI, influenza, and diarrhea in children by Zhang, Zhuxia, Xu, Xijin, Qian, Ziyi, Zhong, Qi, Wang, Qihua, Hylkema, Machteld N., Snieder, Harold, Huo, Xia

“…N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-quinone) has received extensive attention due to its ubiquitous distribution and potential…”
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Increased memory T cell populations in Pb-exposed children from an e-waste-recycling area by Cao, Junjun, Xu, Xijin, Zhang, Yu, Zeng, Zhijun, Hylkema, Machteld N., Huo, Xia

“…•Percentages of CD4+ central memory T cells are increased in e-waste-exposed children.•Blood Pb levels are higher in e-waste-exposed children.•Blood Pb levels…”
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PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height by Zeng, Zhijun, Huo, Xia, Wang, Qihua, Wang, Chenyang, Hylkema, Machteld N., Xu, Xijin

“…Exposure to atmospheric fine particle matter (PM2.5) pollution and the absorbed pollutants is known to contribute to numerous adverse health effects in…”
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Elevated expression of AhR and NLRP3 link polycyclic aromatic hydrocarbon exposure to cytokine storm in preschool children by Cheng, Zhiheng, Huo, Xia, Dai, Yifeng, Lu, Xueling, Hylkema, Machteld N., Xu, Xijin

“…•PAH exposure is positively associated with AhR and NLRP3 expression in preschoolers.•PAH exposure is positively correlated with nine cytokine levels.•AhR and…”
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Associations of co-exposure to polycyclic aromatic hydrocarbons and lead (Pb) with IGF1 methylation in peripheral blood of preschool children from an e-waste recycling area by Huo, Xia, Xu, Xijin, Wang, Qihua, Zhang, Jian, Hylkema, Machteld N., Zeng, Zhijun

“…Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) or lead (Pb) is associated with epigenetic modifications. However, the effects of their…”
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PAH exposure is associated with enhanced risk for pediatric dyslipidemia through serum SOD reduction by Wang, Qihua, Xu, Xijin, Zeng, Zhijun, Hylkema, Machteld N., Cai, Zongwei, Huo, Xia

“…[Display omitted] •Dyslipidemia risk is increased in PAH-exposed children.•PAH exposure and SOD reduction are linked to lower HDL concentration.•PAH exposure…”
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Alterations of gut microbiota and its metabolomics in children with 6PPDQ, PBDE, PCB, and metal(loid) exposure by Zhang, Zhuxia, Zhong, Qi, Qian, Ziyi, Zeng, Xiang, Zhang, Jian, Xu, Xijin, Hylkema, Machteld N, Nolte, Ilja M, Snieder, Harold, Huo, Xia

“…The composition and metabolites of the gut microbiota can be altered by environmental pollutants. However, the effect of co-exposure to multiple pollutants on…”
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The potential for targeted rewriting of epigenetic marks in COPD as a new therapeutic approach by Wu, Dan-Dan, Song, Juan, Bartel, Sabine, Krauss-Etschmann, Susanne, Rots, Marianne G., Hylkema, Machteld N.

“…Chronic obstructive pulmonary disease (COPD) is an age and smoking related progressive, pulmonary disorder presenting with poorly reversible airflow limitation…”
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Distinct macrophage phenotypes in allergic and nonallergic lung inflammation by Robbe, Patricia, Draijer, Christina, Borg, Thiago R, Luinge, Marjan, Timens, Wim, Wouters, Inge M, Melgert, Barbro N, Hylkema, Machteld N

“…Chronic exposure to farm environments is a risk factor for nonallergic lung disease. In contrast to allergic asthma, in which type 2 helper T cell (Th2)…”
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More alternative activation of macrophages in lungs of asthmatic patients by Melgert, Barbro N., PhD, ten Hacken, Nick H., MD, PhD, Rutgers, Bea, BSc, Timens, Wim, MD, PhD, Postma, Dirkje S., MD, PhD, Hylkema, Machteld N., PhD

“…[...]a significantly higher percentage of macrophages with an alternatively activated phenotype (ie, either CD206 [macrophage mannose receptor] or stabilin-1…”
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Dual role of YM1+ M2 macrophages in allergic lung inflammation by Draijer, Christina, Robbe, Patricia, Boorsma, Carian E., Hylkema, Machteld N., Melgert, Barbro N.

“…Alternatively activated (M2 or YM1+) macrophages have been associated with the development of asthma but their contribution to disease initiation and…”
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Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways by Draijer, Christina, Boorsma, Carian E, Robbe, Patricia, Timens, Wim, Hylkema, Machteld N, Ten Hacken, Nick H, van den Berge, Maarten, Postma, Dirkje S, Melgert, Barbro N

“…Previously, we reported higher numbers of CD206+ M2 in lungs of patients with asthma compared with healthy controls, though in a relatively small sample size…”
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Macrophages: regulators of sex differences in asthma? by Melgert, Barbro N, Oriss, Timothy B, Qi, Zengbiao, Dixon-McCarthy, Barbara, Geerlings, Marie, Hylkema, Machteld N, Ray, Anuradha

“…Females are more susceptible to development of asthma than are males. In a mouse model of ovalbumin-induced airway inflammation, with aggravated disease in…”
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Oral application of vancomycin alters murine lung microbiome and pulmonary immune responses by Pfeiffer, Stefan, Jatzlauk, Gregor, Lund, Joni V., Boateng, Eistine, Kovacevic, Draginja, N. Hylkema, Machteld, Bartel, Sabine, Schloter, Michael, Krauss‐Etschmann, Susanne

“…Early life exposures to antibiotics negatively impact respiratory health and are associated with an increased risk of childhood asthma. It is explained that…”
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3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes by Migulina, Nataliya, de Hilster, Roderick H J, Bartel, Sabine, Vedder, Rolf H J, van den Berge, Maarten, Nagelkerke, Anika, Timens, Wim, Harmsen, Martin C, Hylkema, Machteld N, Brandsma, Corry-Anke, Burgess, Janette K

“…Fibroblasts are the main producers of extracellular matrix (ECM) responsible for ECM maintenance and repair, a process often disrupted in chronic lung…”
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Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells by Song, Juan, Cano-Rodriquez, David, Winkle, Melanie, Gjaltema, Rutger A F, Goubert, Désirée, Jurkowski, Tomasz P, Heijink, Irene H, Rots, Marianne G, Hylkema, Machteld N

“…Airway mucus hypersecretion contributes to the morbidity and mortality in patients with chronic inflammatory lung diseases. Reducing mucus production is…”
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microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD by Tasena, Hataitip, Faiz, Alen, Timens, Wim, Noordhoek, Jacobien, Hylkema, Machteld N, Gosens, Reinoud, Hiemstra, Pieter S, Spira, Avrum, Postma, Dirkje S, Tew, Gaik W, Grimbaldeston, Michele A, van den Berge, Maarten, Heijink, Irene H, Brandsma, Corry-Anke

“…Chronic mucus hypersecretion (CMH) is a common feature in chronic obstructive pulmonary disease (COPD) and is associated with worse prognosis and quality of…”
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Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells by Wu, Dan-Dan, Lau, Andy T. Y., Xu, Yan-Ming, Reinders-Luinge, Marjan, Koncz, Mihaly, Kiss, Antal, Timens, Wim, Rots, Marianne G., Hylkema, Machteld N.

“…Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little is known about the molecular mechanism of UCHL1 in airway…”
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Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling by Lkhagvadorj, Khosbayar, Zeng, Zhijun, Song, Juan, Reinders-Luinge, Marjan, Kooistra, Wierd, Song, Shanshan, Krauss-Etschmann, Susanne, Melgert, Barbro N, Cao, Junjun, Hylkema, Machteld N

“…Prenatal smoke exposure is a risk factor for impaired lung development in children. Recent studies have indicated that amphiregulin (AREG), which is a ligand…”
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