Search Results - "Hylemon, P."

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis by Bajaj, J. S., Heuman, D. M., Hylemon, P. B., Sanyal, A. J., Puri, P., Sterling, R. K., Luketic, V., Stravitz, R. T., Siddiqui, M. S., Fuchs, M., Thacker, L. R., Wade, J. B., Daita, K., Sistrun, S., White, M. B., Noble, N. A., Thorpe, C., Kakiyama, G., Pandak, W. M., Sikaroodi, M., Gillevet, P. M.

“…Summary Background Safety of individual probiotic strains approved under Investigational New Drug (IND) policies in cirrhosis with minimal hepatic…”
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HCV eradication does not impact gut dysbiosis or systemic inflammation in cirrhotic patients by Bajaj, J. S., Sterling, R. K., Betrapally, N. S., Nixon, D. E., Fuchs, M., Daita, K., Heuman, D. M., Sikaroodi, M., Hylemon, P. B., White, M. B., Ganapathy, D., Gillevet, P. M.

“…Summary Background Eradication of hepatitis C virus (HCV) is increasing but its residual impact on the pro‐inflammatory milieu in cirrhosis, which is…”
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Chronic Opioid Therapy is Associated with Gut Dysbiosis in Cirrhosis Independent of Cirrhosis Severity by Bajaj, J.S.S, Sterling, R, Hylemon, P, Nixon, D, Heuman, D, SIkaroodi, M, Gillevet, P

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HCV Eradication does not Impact Gut Dysbiosis or Systemic Inflammation in Cirrhotic Patients by Bajaj, J.S.S, Sterling, R, Hylemon, P, Nixon, D, Fuchs, M, Heuman, D, Sikaroodi, M, Gillevet, P

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Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis by Qiao, L, Studer, E, Leach, K, McKinstry, R, Gupta, S, Decker, R, Kukreja, R, Valerie, K, Nagarkatti, P, El Deiry, W, Molkentin, J, Schmidt-Ullrich, R, Fisher, P B, Grant, S, Hylemon, P B, Dent, P

“…Previous studies have argued that enhanced activity of the epidermal growth factor receptor (EGFR) and the mitogen-activated protein kinase (MAPK) pathway can…”
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The Beneficial Impact of Rifaximin on Systemic and Intestinal Inflammation and Ammonia Occurs even without Microbiota: More than an Antibiotic by Kang, D.J, Balfour Sartor, R, Betrapally, N, Nittono, H, Herzog, J, Hylemon, P, SIkaroodi, M, Gillevet, P, Carroll, I, Kakiyama, G, Zhou, H, Yang, J, Jiao, C, Fan, S, Fiehn, O, Takei, H, Pandak, W, Bajaj, J.S.S

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P499 ALTERED GUT MICROBIOME IS ASSOCIATED WITH NEURO-INFLAMMATION ON BRAIN MRI IN CIRRHOSIS: IMPLICATIONS FOR THE GUT–LIVER–BRAIN AXIS by Bajaj, J.S, Ahluwalia, V.S, Sikaroodi, M, Wade, J, White, M, Heuman, D, Gilles, H, Unser, A, Hylemon, P, Gillevet, P.M

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Bile acid metabolism by fresh human colonic contents: a comparison of caecal versus faecal samples by Thomas, L A, Veysey, M J, French, G, Hylemon, P B, Murphy, G M, Dowling, R H

“…BACKGROUND Deoxycholic acid (DCA), implicated in the pathogenesis of gall stones and colorectal cancer, is mainly formed by bacterial deconjugation…”
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P335 DYSFUNCTIONAL GUT MICROBIOTA IN ILEO-COLONIC MUCOSA AND STOOL IN ALCOHOLIC CIRRHOSIS IS ASSOCIATED WITH ENDOTOXEMIA: IMPLICATIONS FOR BACTERIAL TRANSLOCATION by Bajaj, J.S, Heuman, D, Hylemon, P, Sikaroodi, M, Ridlon, J, Pandak, W.M, Schubert, M, Fuchs, M, White, M, Daita, K, Gillevet, P

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Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells by Hall, E.A., Ren, S., Hylemon, P.B., Rodriguez-Agudo, D., Redford, K., Marques, D., Kang, D., Gil, G., Pandak, W.M.

“…Overexpressing StAR (a mitochondrial cholesterol transporter) increases (>5-fold) the rate of 27-hydroxylation of cholesterol and the rates of bile acid…”
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Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway by Gupta, Seema, Stravitz, R. Todd, Dent, Paul, Hylemon, Phillip B.

“…Cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the neutral pathway of bile acid biosynthesis, is feedback-inhibited at the transcriptional…”
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192 RIFAXIMIN IMPROVES COGNITION AND ENDOTOXEMIA IN MINIMAL HEPATIC ENCEPHALOPATHY BY SHIFTING GUT MICROBIAL FUNCTIONALITY WITHOUT ALTERING THEIR ABUNDANCE by Bajaj, J.S, Heuman, D, Sanyal, A, Hylemon, P, Sterling, R.K, Stravitz, R.T, Fuchs, M, Ridlon, J.M, Daita, K, Monteith, P, White, M, Noble, N.A, Fisher, A, Sikaroodi, M, Rangwala, H, Gillevet, P.M

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Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems by Hylemon, P.B., Harder, J.

“…Isoprenoic compounds play a major part in the global carbon cycle. Biosynthesis and mineralization by aerobic bacteria have been intensively studied. This…”
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Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis by Pandak, W M, Schwarz, C, Hylemon, P B, Mallonee, D, Valerie, K, Heuman, D M, Fisher, R A, Redford, K, Vlahcevic, Z R

“…The initial and rate-limiting step in the classic pathway of bile acid biosynthesis is 7alpha-hydroxylation of cholesterol, a reaction catalyzed by cholesterol…”
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Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat by Vlahcevic, ZR, Stravitz, RT, Heuman, DM, Hylemon, PB, Pandak, WM

“…BACKGROUND & AIMS: Cholesterol degradation to bile acids occurs via "classic" or "alternative" bile acid biosynthetic pathways. The aim of this study was to…”
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A role for both Ets and C/EBP transcription factors and mRNA stabilization in the MAPK-dependent increase in p21 (Cip-1/WAF1/mda6) protein levels in primary hepatocytes by Park, J S, Qiao, L, Gilfor, D, Yang, M Y, Hylemon, P B, Benz, C, Darlington, G, Firestone, G, Fisher, P B, Dent, P

“…In primary hepatocytes and HepG2 hepatoma cells, prolonged activation of the p42/44 mitogen-activated protein kinase (MAPK) pathway is associated with a…”
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LXRα is the dominant regulator of CYP7A1 transcription by Gupta, Seema, Pandak, William M, Hylemon, Phillip B

“…Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the rate-limiting step in the classic pathway of bile acid biosynthesis. Dietary cholesterol stimulates CYP7A1…”
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151 URINARY MAGNETIC RESONANCE SPECTROSCOPY IN PATIENTS WITH HEPATIC ENCEPHALOPATHY: CITRATE CORRELATES WITH ASYMMETRIC DIMETHYLARGININE AND GUT MICROBIAL SPECIES AND CAN PREDICT RECURRENCE AFTER LACTULOSE DISCONTINUATION by Bajaj, J, McPhail, M.J, Heuman, D.M, Bell, D, Gillevet, P, Sikaroodi, M, Sanyal, A.J, Sharif, M.I, Ridlon, J, Hylemon, P, Taylor-Robinson, S

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Assessment of fecal bacteria with bile acid 7 alpha-dehydroxylating activity for the presence of bai-like genes by DOERNER, K. C, TAKAMINE, F, LAVOIE, C. P, MALLONEE, D. H, HYLEMON, P. B

“…Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Hepatocellular protein kinase C activation by bile acids: implications for regulation of cholesterol 7 alpha-hydroxylase by Stravitz, R T, Rao, Y P, Vlahcevic, Z R, Gurley, E C, Jarvis, W D, Hylemon, P B

“…We have recently shown that taurocholate (TCA) represses the transcriptional activity of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme of the bile…”
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