Search Results - "Hylander, Bonnie L"

Manipulation of Ambient Housing Temperature To Study the Impact of Chronic Stress on Immunity and Cancer in Mice by Hylander, Bonnie L, Gordon, Christopher J, Repasky, Elizabeth A

“…Mice are the preeminent research organism in which to model human diseases and study the involvement of the immune response. Rapidly accumulating evidence…”
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Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response by Qiao, Guanxi, Chen, Minhui, Bucsek, Mark J, Repasky, Elizabeth A, Hylander, Bonnie L

“…An immune response must be tightly controlled so that it will be commensurate with the level of response needed to protect the organism without damaging normal…”
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Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation by Chen, Minhui, Qiao, Guanxi, Hylander, Bonnie L., Mohammadpour, Hemn, Wang, Xiang-Yang, Subjeck, John R., Singh, Anurag K., Repasky, Elizabeth A.

“…The abscopal effect following ionizing radiation therapy (RT) is considered to be a rare event. This effect does occur more frequently when combined with other…”
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Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature by Kokolus, Kathleen M., Capitano, Maegan L., Lee, Chen-Ting, Eng, Jason W.-L., Waight, Jeremy D., Hylander, Bonnie L., Sexton, Sandra, Hong, Chi-Chen, Gordon, Christopher J., Abrams, Scott I., Repasky, Elizabeth A.

“…We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature…”
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Temperature as a modulator of the gut microbiome: what are the implications and opportunities for thermal medicine? by Hylander, Bonnie L., Repasky, Elizabeth A.

“…There is substantial research being conducted on the relationships between the gut microbiome, the immune response and health and disease. Environmental…”
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A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response by Eng, Jason W.-L., Kokolus, Kathleen M., Reed, Chelsey B., Hylander, Bonnie L., Ma, Wen W., Repasky, Elizabeth A.

“…Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in…”
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Systemic Endocrine Instigation of Indolent Tumor Growth Requires Osteopontin by McAllister, Sandra S., Gifford, Ann M., Greiner, Ashley L., Kelleher, Stephen P., Saelzler, Matthew P., Ince, Tan A., Reinhardt, Ferenc, Harris, Lyndsay N., Hylander, Bonnie L., Repasky, Elizabeth A., Weinberg, Robert A.

“…The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find…”
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Mild Elevation of Body Temperature Reduces Tumor Interstitial Fluid Pressure and Hypoxia and Enhances Efficacy of Radiotherapy in Murine Tumor Models by SEN, Arindam, CAPITANO, Maegan L, SPERNYAK, Joseph A, SCHUECKLER, John T, THOMAS, Seneca, SINGH, Anurag K, EVANS, Sharon S, HYLANDER, Bonnie L, REPASKY, Elizabeth A

“…Human and rodent solid tumors often exhibit elevated interstitial fluid pressure (IFP). This condition is recognized as a prognostic indicator for reduced…”
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Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility by Hylander, Bonnie L, Repasky, Elizabeth A, Sexton, Sandra

“…Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This review…”
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Origin of the vasculature supporting growth of primary patient tumor xenografts by Hylander, Bonnie L, Punt, Natalie, Tang, Haikuo, Hillman, Joanna, Vaughan, Mary, Bshara, Wiam, Pitoniak, Rose, Repasky, Elizabeth A

“…Studies of primary patient tumor xenografts grown in immunodeficient mice have shown that these tumors histologically and genetically closely resemble the…”
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Defining immunological impact and therapeutic benefit of mild heating in a murine model of arthritis by Lee, Chen-Ting, Kokolus, Kathleen M, Leigh, Nicholas D, Capitano, Maegan, Hylander, Bonnie L, Repasky, Elizabeth A

“…Traditional treatments, including a variety of thermal therapies have been known since ancient times to provide relief from rheumatoid arthritis (RA) symptoms…”
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Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo by Shao, Huanjie, Gao, Chun, Tang, Haikuo, Zhang, Hao, Roberts, Lewis R, Hylander, Bonnie L, Repasky, Elizabeth A, Ma, Wen W, Qiu, Jingxin, Adjei, Alex A, Dy, Grace K, Yu, Chunrong

“…Background & Aims The mammalian target of rapamycin (mTOR) plays a pivotal role in hepatocellular carcinoma (HCC). Previous studies indicated that inhibition…”
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Temperature matters: the potential impact of thermoregulatory mechanisms in brain-body physiology by Repasky, Elizabeth A, Hylander, Bonnie L, Mohammadpour, Hemn

“…Thermoregulation, responsible for maintaining a stable core temperature during wide fluctuations in external and internal thermal environments, is an iconic…”
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β2 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells by Mohammadpour, Hemn, MacDonald, Cameron R, Qiao, Guanxi, Chen, Minhui, Dong, Bowen, Hylander, Bonnie L, McCarthy, Philip L, Abrams, Scott I, Repasky, Elizabeth A

“…Catecholamines released by sympathetic nerves can activate adrenergic receptors present on nearly every cell type, including myeloid-derived suppressor cells…”
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Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand/TRAIL by Cheng, Jinrong, Hylander, Bonnie L, Baer, Maria R, Chen, Xing, Repasky, Elizabeth A

“…Targeting death receptors with tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has the remarkable potential to selectively kill malignant cells…”
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β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress by Qiao, Guanxi, Bucsek, Mark J., Winder, Nicolette M., Chen, Minhui, Giridharan, Thejaswini, Olejniczak, Scott H., Hylander, Bonnie L., Repasky, Elizabeth A.

“…Primary and secondary lymphoid organs are heavily innervated by the autonomic nervous system. Norepinephrine, the primary neurotransmitter secreted by…”
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The anti-tumor effect of Apo2L/TRAIL on patient pancreatic adenocarcinomas grown as xenografts in SCID mice by Hylander, Bonnie L, Pitoniak, Rose, Penetrante, Remedios B, Gibbs, John F, Oktay, Dilek, Cheng, Jinrong, Repasky, Elizabeth A

“…BACKGROUND: Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in…”
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β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8 + T Cells and Undermines Checkpoint Inhibitor Therapy by Bucsek, Mark J, Qiao, Guanxi, MacDonald, Cameron R, Giridharan, Thejaswini, Evans, Lauren, Niedzwecki, Brian, Liu, Haichao, Kokolus, Kathleen M, Eng, Jason W-L, Messmer, Michelle N, Attwood, Kristopher, Abrams, Scott I, Hylander, Bonnie L, Repasky, Elizabeth A

“…The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We…”
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Housing temperature plays a critical role in determining gut microbiome composition in research mice: Implications for experimental reproducibility by Hylander, Bonnie L., Qiao, Guanxi, Cortes Gomez, Eduardo, Singh, Prashant, Repasky, Elizabeth A.

“…Preclinical mouse models are widely used for studying mechanisms of disease and responses to therapeutics, however there is concern about the lack of…”
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Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5 by Eng, Jason W.-L., Mace, Thomas A., Sharma, Rohit, Twum, Danielle Y. F., Peng, Peng, Gibbs, John F., Pitoniak, Rosemarie, Reed, Chelsey B., Abrams, Scott I., Repasky, Elizabeth A., Hylander, Bonnie L.

“…BackgroundTherapeutic resistance and tumor recurrence are two major hurdles in the treatment of pancreatic ductal adenocarcinoma. Recent findings suggest that…”
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