Search Results - "Hyjek‐Składanowska, Malwina"
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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins
Published in Journal of the American Chemical Society (22-04-2020)“…The phosphorothioate backbone modification (PS) is one of the most widely used chemical modifications for enhancing the drug-like properties of nucleic…”
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Core spliceosomal Sm proteins as constituents of cytoplasmic mRNPs in plants
Published in The Plant journal : for cell and molecular biology (01-08-2020)“…SUMMARY In recent years, research has increasingly focused on the key role of post‐transcriptional regulation of messenger ribonucleoprotein (mRNP) function…”
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Different Patterns of mRNA Nuclear Retention during Meiotic Prophase in Larch Microsporocytes
Published in International journal of molecular sciences (07-08-2021)“…Recent studies show a crucial role of post-transcriptional processes in the regulation of gene expression. Our research has shown that mRNA retention in the…”
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Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding
Published in Nucleic acids research (22-02-2023)“…The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also…”
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Functional nuclear retention of pre-mRNA involving Cajal bodies during meiotic prophase in European larch (Larix decidua)
Published in The Plant cell (24-05-2022)“…Gene regulation ensures that the appropriate genes are expressed at the proper time. Nuclear retention of incompletely spliced or mature mRNAs is emerging as a…”
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Disulfide bridge cross-linking between protein and the RNA backbone as a tool to study RNase H1
Published in Bioorganic & medicinal chemistry (01-12-2020)“…[Display omitted] The chemical cross-linking of complexes of proteins with nucleic acids is often used in structural and mechanistic studies of these…”
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Reproducible and efficient new method of RNA 3'-end labelling by CutA nucleotidyltransferase-mediated CC-tailing
Published in RNA biology (12-11-2021)“…Despite the development of non-radioactive DNA/RNA labelling methods, radiolabelled nucleic acids are commonly used in studies focused on the determination of…”
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Reproducible and efficient new method of RNA 3'-end labelling by CutA nucleotidyltransferase-mediated CC-tailing
Published in RNA Biology (12-11-2021)“…Despite the development of non-radioactive DNA/RNA labelling methods, radiolabelled nucleic acids are commonly used in studies focused on the determination of…”
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