Search Results - "Hyeon, Do Young"

Single-cell multiomics: technologies and data analysis methods by Lee, Jeongwoo, Hyeon, Do Young, Hwang, Daehee

“…Advances in single-cell isolation and barcoding technologies offer unprecedented opportunities to profile DNA, mRNA, and proteins at a single-cell resolution…”
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Integrative analysis of transcriptomic data for identification of T-cell activation-related mRNA signatures indicative of preterm birth by Yoo, Jae Young, Hyeon, Do Young, Shin, Yourae, Kim, Soo Min, You, Young-Ah, Kim, Daye, Hwang, Daehee, Kim, Young Ju

“…Preterm birth (PTB), defined as birth at less than 37 weeks of gestation, is a major determinant of neonatal mortality and morbidity. Early diagnosis of PTB…”
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CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity by Park, Myo-Hyeon, Kim, Ae Kyung, Manandhar, Sarala, Oh, Su-Young, Jang, Gun-Hyuk, Kang, Li, Lee, Dong-Won, Hyeon, Do Young, Lee, Sun-Hee, Lee, Hye Eun, Huh, Tae-Lin, Suh, Sang Heon, Hwang, Daehee, Byun, Kyunghee, Park, Hae-Chul, Lee, You Mie

“…CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of…”
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E3 ligase BRUTUS Is a Negative Regulator for the Cellular Energy Level and the Expression of Energy Metabolism-Related Genes Encoded by Two Organellar Genomes in Leaf Tissues by Choi, Bongsoo, Hyeon, Do Young, Lee, Juhun, Long, Terri A, Hwang, Daehee, Hwang, Inhwan

“…E3 ligase BRUTUS (BTS), a putative iron sensor, is expressed in both root and shoot tissues in seedlings of Arabidopsis thaliana. The role of BTS in root…”
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Evolution of the multi-tRNA synthetase complex and its role in cancer by Hyeon, Do Young, Kim, Jong Hyun, Ahn, Tae Jin, Cho, Yeshin, Hwang, Daehee, Kim, Sunghoon

“…Aminoacyl-tRNA synthetases (ARSs) are enzymes that ligate their cognate amino acids to tRNAs for protein synthesis. However, recent studies have shown that…”
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PD-L1-directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer-associated fibroblasts in pancreatic cancer by Kim, Duk Ki, Jeong, Juhee, Lee, Dong Sun, Hyeon, Do Young, Park, Geon Woo, Jeon, Suwan, Lee, Kyung Bun, Jang, Jin-Young, Hwang, Daehee, Kim, Ho Min, Jung, Keehoon

“…Pancreatic ductal adenocarcinoma (PDAC) has a poor 5-year overall survival rate. Patients with PDAC display limited benefits after undergoing chemotherapy or…”
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Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila by Lee, Kyung-Ah, Cho, Kyu-Chan, Kim, Boram, Jang, In-Hwan, Nam, Kibum, Kwon, Young Eun, Kim, Myungjin, Hyeon, Do Young, Hwang, Daehee, Seol, Jae-Hong, Lee, Won-Jae

“…DUOX, a member of the NADPH oxidase family, acts as the first line of defense against enteric pathogens by producing microbicidal reactive oxygen species. DUOX…”
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Ethylene responsive factor34 mediates stress‐induced leaf senescence by regulating salt stress‐responsive genes by Park, Sung‐Jin, Park, Sanghoon, Kim, Yongmin, Hyeon, Do Young, Park, Hyunsoo, Jeong, Junyong, Jeong, Ukcheol, Yoon, Yeong Seon, You, Daesang, Kwak, Junmin, Timilsina, Rupak, Hwang, Daehee, Kim, Jeongsik, Woo, Hye Ryun

“…Leaf senescence proceeds with age but is modulated by various environmental stresses and hormones. Salt stress is one of the most well‐known environmental…”
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RUNX3 methylation drives hypoxia-induced cell proliferation and antiapoptosis in early tumorigenesis by Lee, Sun Hee, Hyeon, Do Young, Yoon, Soo-Hyun, Jeong, Ji-Hak, Han, Saeng-Myung, Jang, Ju-Won, Nguyen, Minh Phuong, Chi, Xin-Zi, An, Sojin, Hyun, Kyung-gi, Jung, Hee-Jung, Song, Ji-Joon, Bae, Suk-Chul, Kim, Woo-Ho, Hwang, Daehee, Lee, You Mie

“…Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttranslational…”
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Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects by Kwon, Min Jee, Han, Myeong Hoon, Bagley, Joshua A., Hyeon, Do Young, Ko, Byung Su, Lee, Yun Mi, Cha, In Jun, Kim, Seung Yeol, Kim, Dong Young, Kim, Ho Min, Hwang, Daehee, Lee, Sung Bae, Jan, Yuh Nung

“…Neurodegenerative disorders, such as Huntington’s diseases and spinocerebellar ataxias (SCAs), are driven by proteins with expanded polyglutamine (polyQ)…”
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Distinctive CD39+CD9+ lung interstitial macrophages suppress IL-23/Th17-mediated neutrophilic asthma by inhibiting NETosis by Han, Seunghan, Kim, Bomin, Hyeon, Do Young, Jeong, Daeun, Ryu, Jaechan, Nam, Jae-Sung, Choi, Yoon Ha, Kim, Bo-Ram, Park, Sang Chul, Chung, Youn Wook, Shin, Sung Jae, Lee, June-Yong, Kim, Jong Kyoung, Park, Jihye, Lee, Sei Won, Kim, Tae-Bum, Cheon, Jae Hee, Cho, Hyung-Ju, Kim, Chang-Hoon, Yoon, Joo-Heon, Hwang, Daehee, Ryu, Ji-Hwan

“…The IL-23-Th17 axis is responsible for neutrophilic inflammation in various inflammatory diseases. Here, we discover a potential pathway to inhibit…”
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A pathogen‐derived metabolite induces microglial activation via odorant receptors by Lee, NaHye, Jae, YoonGyu, Kim, Minhyung, Cho, TaeHo, Lee, ChaeEun, Hong, Yu Ri, Hyeon, Do Young, Ahn, Sanghyun, Kwon, Hongmok, Kim, Kyul, Jung, Jae Hoon, Chae, Sehyun, Shin, Jeong‐Oh, Bok, Jinwoong, Byun, Youngjoo, Hwang, Daehee, Koo, JaeHyung

“…Microglia (MG), the principal neuroimmune sentinels in the brain, continuously sense changes in their environment and respond to invading pathogens, toxins,…”
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Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer by Roh, Jae-il, Lee, Jaehoon, Sung, Young-Hoon, Oh, Jahyun, Hyeon, Do Young, Kim, Yujin, Lee, Seungeon, Devkota, Sushil, Kim, Hye Jeong, Park, Bomin, Nam, Taewook, Song, Yaechan, Kim, Yonghwan, Hwang, Daehee, Lee, Han-Woong

“…KRAS-mutant non-small cell lung cancer (NSCLC) is a major lung cancer subtype that leads to many cancer-related deaths worldwide. Although numerous studies on…”
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Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons by Chung, Chang Geon, Kwon, Min Jee, Jeon, Keun Hye, Hyeon, Do Young, Han, Myeong Hoon, Park, Jeong Hyang, Cha, In Jun, Cho, Jae Ho, Kim, Kunhyung, Rho, Sangchul, Kim, Gyu Ree, Jeong, Hyobin, Lee, Jae Won, Kim, TaeSoo, Kim, Keetae, Kim, Kwang Pyo, Ehlers, Michael D., Hwang, Daehee, Lee, Sung Bae

“…Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here,…”
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DNA repair and cholesterol-mediated drug efflux induce dose-dependent chemoresistance in nutrient-deprived neuroblastoma cells by Chae, Soo Yeon, Nam, Dowoon, Hyeon, Do Young, Hong, Areum, Lee, Timothy Dain, Kim, Sujin, Im, Dongjoon, Hong, Jiwon, Kang, Chaewon, Lee, Ji Won, Hwang, Daehee, Lee, Sang-Won, Kim, Hugh I.

“…Neuroblastoma is a solid, heterogeneous pediatric tumor. Chemotherapy is widely used to treat neuroblastoma. However, dose-dependent responses and…”
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Gene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis by Choi, Seung Hee, Hyeon, Do Young, Lee, ll Hwan, Park, Su Jin, Han, Seungmin, Lee, In Chul, Hwang, Daehee, Nam, Hong Gil

“…Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional…”
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Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype by Min, Byong-Keol, Park, Sungmi, Kang, Hyeon-Ji, Kim, Dong Wook, Ham, Hye Jin, Ha, Chae-Myeong, Choi, Byung-Jun, Lee, Jung Yi, Oh, Chang Joo, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Byung-Gyu, Jeon, Jae-Han, Hyeon, Do Young, Hwang, Daehee, Kim, Yong-Hoon, Lee, Chul-Ho, Lee, Taeho, Kim, Jung-Whan, Choi, Yeon-Kyung, Park, Keun-Gyu, Chawla, Ajay, Lee, Jongsoon, Harris, Robert A, Lee, In-Kyu

“…Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate…”
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Phytohormonal regulation determines the organization pattern of shoot aerenchyma in greater duckweed (Spirodela polyrhiza) by Kim, Min, Hyeon, Do Young, Kim, Kyungyoon, Hwang, Daehee, Lee, Yuree

“…Abstract Airspace or aerenchyma is crucial for plant development and acclimation to stresses such as hypoxia, drought, and nutritional deficiency. Although…”
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Bacterial Nucleoside Catabolism Controls Quorum Sensing and Commensal-to-Pathogen Transition in the Drosophila Gut by Kim, Eun-Kyoung, Lee, Kyung-Ah, Hyeon, Do Young, Kyung, Minsoo, Jun, Kyu-Yeon, Seo, Seung Hee, Hwang, Daehee, Kwon, Youngjoo, Lee, Won-Jae

“…Although the gut microbiome is generally symbiotic or commensal, some microbiome members become pathogenic under certain circumstances. However, the factors…”
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Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase by Chung, Hye Yoon, Lee, Geon Seong, Nam, Soo Hyun, Lee, Jeong Hyeon, Han, Jeong Pil, Song, Sumin, Kim, Gap-Don, Jung, Choonkyun, Hyeon, Do Young, Hwang, Daehee, Choi, Byung-Ok, Yeom, Su Cheong

“…Mutations in the Microrchidia CW-Type Zinc Finger 2 (MORC2) GHKL ATPase module cause a broad range of neuropathies, such as Charcot-Marie-Tooth disease type…”
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