Search Results - "Hyde, Thomas M"
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Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
Published in Cell stem cell (04-08-2016)“…Recent advances in 3D culture systems have led to the generation of brain organoids that resemble different human brain regions; however, a 3D organoid model…”
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Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
Published in Nature neuroscience (01-01-2016)“…DNA methylation in human brain shows dramatic variation across development. Genetic loci implicated in risk for schizophrenia are enriched for epigenetic…”
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Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis
Published in Nature neuroscience (01-08-2018)“…Genome-wide association studies have identified 108 schizophrenia risk loci, but biological mechanisms for individual loci are largely unknown. Using…”
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Dynamic regulation of RNA editing in human brain development and disease
Published in Nature neuroscience (01-08-2016)“…RNA sequences are generally considered to be a mirror of DNA sequences. However, that dogma has become challenged as RNA editing is increasingly recognized…”
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DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex
Published in American journal of human genetics (10-02-2012)“…The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain regions to mature. To investigate the role of epigenetics in the…”
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Temporal dynamics and genetic control of transcription in the human prefrontal cortex
Published in Nature (London) (27-10-2011)“…Gene expression in the human brain Gene expression controls and dictates everything from development and plasticity to ongoing neurogenesis in the brain, yet…”
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Large-Scale Cellular-Resolution Gene Profiling in Human Neocortex Reveals Species-Specific Molecular Signatures
Published in Cell (13-04-2012)“…Although there have been major advances in elucidating the functional biology of the human brain, relatively little is known of its cellular and molecular…”
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Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1
Published in Neuron (Cambridge, Mass.) (06-04-2016)“…Transcription Factor 4 (TCF4) is a clinically pleiotropic gene associated with schizophrenia and Pitt-Hopkins syndrome (PTHS). To gain insight about the…”
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Spatio-temporal transcriptome of the human brain
Published in Nature (London) (27-10-2011)“…Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the…”
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dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues
Published in Nucleic acids research (19-06-2020)“…Abstract Multiplex single-molecule fluorescent in situ hybridization (smFISH) is a powerful method for validating RNA sequencing and emerging spatial…”
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Somatic LINE-1 retrotransposition in cortical neurons and non-brain tissues of Rett patients and healthy individuals
Published in PLoS genetics (11-04-2019)“…Mounting evidence supports that LINE-1 (L1) retrotransposition can occur postzygotically in healthy and diseased human tissues, contributing to genomic…”
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Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s disease
Published in Acta neuropathologica (01-04-2019)“…Late-onset Alzheimer’s disease (AD) is a complex age-related neurodegenerative disorder that likely involves epigenetic factors. To better understand the…”
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Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity
Published in Cell stem cell (03-07-2014)“…Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has…”
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A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
Published in Nature medicine (01-06-2016)“…eQTL analysis of human brain RNA-seq data targeted to genes within the 10q24.32 schizophrenia-associated locus reveals that the risk SNP in this region is…”
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Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation
Published in Genome Biology (26-09-2019)“…DNA methylation (DNAm) is a critical regulator of both development and cellular identity and shows unique patterns in neurons. To better characterize…”
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Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
Published in Nature communications (02-09-2021)“…DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of gene-environment interaction. Using whole-genome bisulfite sequencing,…”
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P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Published in Nature communications (26-03-2021)“…Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression…”
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Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
Published in Journal of psychiatry & neuroscience (01-11-2016)“…Background Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number of major psychiatric diseases, including…”
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Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
Published in PLoS genetics (13-10-2023)“…The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene…”
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A single-cell transcriptome atlas of glial diversity in the human hippocampus across the postnatal lifespan
Published in Cell stem cell (03-11-2022)“…The molecular diversity of glia in the human hippocampus and their temporal dynamics over the lifespan remain largely unknown. Here, we performed…”
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