Search Results - "Hyde, John E"

Drug-resistant malaria - an insight by Hyde, John E

“…Despite intensive research extending back to the 1930s, when the first synthetic antimalarial drugs made their appearance, the repertoire of clinically…”
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Folate metabolism in human malaria parasites—75 years on by Müller, Ingrid B., Hyde, John E.

“…The current application of antifolates to malaria parasites, resistance to these drugs, new insights into folate metabolism, its potential for providing novel…”
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Exploring the folate pathway in Plasmodium falciparum by Hyde, John E.

“…As in centuries past, the main weapon against human malaria infections continues to be intervention with drugs, despite the widespread and increasing frequency…”
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Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs by Hyde, John E.

“…Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the…”
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Antifolate resistance in Africa and the 164-dollar question by Hyde, John E.

“…The spread of Plasmodium falciparum carrying a quadruply mutated dhfr gene to Africa has been widely predicted to have profoundly adverse consequences, as such…”
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next? by Sibley, Carol Hopkins, Hyde, John E, Sims, Paul F.G, Plowe, Christopher V, Kublin, James G, Mberu, Edward K, Cowman, Alan F, Winstanley, Peter A, Watkins, William M, Nzila, Alexis M

“…Chemotherapy remains the only practicable tool to control falciparum malaria in sub-Saharan Africa, where >90% of the world's burden of malaria mortality and…”
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Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition by Nirmalan, Niroshini, Sims, Paul F. G., Hyde, John E.

“…Summary The ability to measure accurately comparative levels of protein expression after drug challenge, metabolic stress, developmental programming or other…”
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Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy by Nzila, Alexis, Ward, Steve A., Marsh, Kevin, Sims, Paul F.G., Hyde, John E.

“…New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the…”
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Prevalence of Toxoplasma gondii in commercial meat products as monitored by polymerase chain reaction – food for thought? by Aspinall, Tanya V., Marlee, Damian, Hyde, John E., Sims, Paul F.G.

“…DNA was extracted from 71 meat samples obtained from UK retail outlets. All of these DNA preparations gave the expected polymerase chain reaction products when…”
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Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria by Triglia, Tony, Wang, Ping, Sims, Paul F.G., Hyde, John E., Cowman, Alan F.

“…We have exploited the recently developed ability to trans‐ fect the malaria parasite Plasmodium falciparum to investigate the role of polymorphisms in the…”
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6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria by PRIBAT, Anne, JEANGUENIN, Linda, LARA-NUNEZ, Aurora, ZIEMAK, Michael J, HYDE, John E, DE CRECY-LAGARD, Valérie, HANSON, Andrew D

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A protein-centric approach for the identification of folate enzymes from the malarial parasite, Plasmodium falciparum, using OFFGEL™ solution-based isoelectric focussing and mass spectrometry by O'Cualain, Ronan D M, Hyde, John E, Sims, Paul F G

“…Plasmodium species are difficult to study using proteomic technology because they contain large amounts of haemoglobin-derived products (HDP), generated by…”
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A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance by Southworth, Paul M, Hyde, John E, Sims, Paul F G

“…Selected reaction monitoring mass spectrometry has been combined with the use of an isotopically labelled synthetic protein, made up of proteotypic tryptic…”
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Dynamic subcellular localization of isoforms of the folate pathway enzyme serine hydroxymethyltransferase (SHMT) through the erythrocytic cycle of Plasmodium falciparum by Read, Martin, Müller, Ingrid B, Mitchell, Sarah L, Sims, Paul F G, Hyde, John E

“…The folate pathway enzyme serine hydroxymethyltransferase (SHMT) converts serine to glycine and 5,10-methylenetetrahydrofolate and is essential for the…”
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The Molecular Basis of Sulfonamide Resistance in Toxoplasma gondii and Implications for the Clinical Management of Toxoplasmosis by Aspinall, Tanya V., Joynson, David H. M., Guy, Edward, Hyde, John E., Sims, Paul F. G.

“…Polymerase chain reaction amplification and DNA sequencing of the Toxoplasma gondii dihydropteroate synthase gene (dhps) identified 4 alleles among parasite…”
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Targeting purine and pyrimidine metabolism in human apicomplexan parasites by Hyde, John E

“…Synthesis de novo, acquisition by salvage and interconversion of purines and pyrimidines represent the fundamental requirements for their eventual assembly…”
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Drug-resistant malaria by Hyde, John E.

“…In the past 21 years, a modest increase in the range of antimalarial drugs approved for clinical use has been complemented by a more impressive expansion in…”
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Antimalarial drugs: modes of action and mechanisms of parasite resistance by Müller, Ingrid B, Hyde, John E

“…Malaria represents one of the most serious threats to human health worldwide, and preventing and curing this parasitic disease still depends predominantly on…”
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Vitamin B metabolism in Plasmodium falciparum as a source of drug targets by Müller, Ingrid B, Hyde, John E, Wrenger, Carsten

“…The malaria parasite Plasmodium falciparum depends primarily on nutrient sources from its human host. Most compounds, such as glucose, purines, amino acids, as…”
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Fine targeting of purine salvage in Cryptosporidium parasites by Hyde, John E

“…The apicomplexan pathogen Cryptosporidium parvum poses major logistical problems in the search for effective drug treatments. These treatments are required…”
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