Search Results - "Hyatt, Elzbieta"

A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene by Kemaladewi, Dwi U., Bassi, Prabhpreet S., Erwood, Steven, Al-Basha, Dhekra, Gawlik, Kinga I., Lindsay, Kyle, Hyatt, Elzbieta, Kember, Rebekah, Place, Kara M., Marks, Ryan M., Durbeej, Madeleine, Prescott, Steven A., Ivakine, Evgueni A., Cohn, Ronald D.

“…Neuromuscular disorders are often caused by heterogeneous mutations in large, structurally complex genes. Targeting compensatory modifier genes could be…”
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Correction of a splicing defect in a mouse model of congenital muscular dystrophy type 1A using a homology-directed-repair-independent mechanism by Kemaladewi, Dwi U, Maino, Eleonora, Hyatt, Elzbieta, Hou, Huayun, Ding, Maylynn, Place, Kara M, Zhu, Xinyi, Bassi, Prabhpreet, Baghestani, Zahra, Deshwar, Amit G, Merico, Daniele, Xiong, Hui Y, Frey, Brendan J, Wilson, Michael D, Ivakine, Evgueni A, Cohn, Ronald D

“…An HDR-independent therapeutic genome-editing approach corrected the splice-site mutation in Lama2 in a mouse model of congenital muscular dystrophy type 1A,…”
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Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders by Wojtal, Daria, Kemaladewi, Dwi U., Malam, Zeenat, Abdullah, Sarah, Wong, Tatianna W.Y., Hyatt, Elzbieta, Baghestani, Zahra, Pereira, Sergio, Stavropoulos, James, Mouly, Vincent, Mamchaoui, Kamel, Muntoni, Francesco, Voit, Thomas, Gonorazky, Hernan D., Dowling, James J., Wilson, Michael D., Mendoza-Londono, Roberto, Ivakine, Evgueni A., Cohn, Ronald D.

“…Clustered regularly interspaced short palindromic repeat (CRISPR) has arisen as a frontrunner for efficient genome engineering. However, the potentially broad…”
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Targeted genome editing in vivo corrects a Dmd duplication restoring wild‐type dystrophin expression by Maino, Eleonora, Wojtal, Daria, Evagelou, Sonia L, Farheen, Aiman, Wong, Tatianna W Y, Lindsay, Kyle, Scott, Ori, Rizvi, Samar Z, Hyatt, Elzbieta, Rok, Matthew, Visuvanathan, Shagana, Chiodo, Amanda, Schneeweiss, Michelle, Ivakine, Evgueni A, Cohn, Ronald D

“…Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately,…”
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A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic Dmd deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy by Wong, Tatianna Wai Ying, Ahmed, Abdalla, Yang, Grace, Maino, Eleonora, Steiman, Sydney, Hyatt, Elzbieta, Chan, Parry, Lindsay, Kyle, Wong, Nicole, Golebiowski, Diane, Schneider, Joel, Delgado-Olguín, Paul, Ivakine, Evgueni A, Cohn, Ronald D

“…Duchenne muscular dystrophy (DMD) is a life-threatening neuromuscular disease caused by the lack of dystrophin, resulting in progressive muscle wasting and…”
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Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity by Gedye, Craig A, Hussain, Ali, Paterson, Joshua, Smrke, Alannah, Saini, Harleen, Sirskyj, Danylo, Pereira, Keira, Lobo, Nazleen, Stewart, Jocelyn, Go, Christopher, Ho, Jenny, Medrano, Mauricio, Hyatt, Elzbieta, Yuan, Julie, Lauriault, Stevan, Meyer, Mona, Kondratyev, Maria, van den Beucken, Twan, Jewett, Michael, Dirks, Peter, Guidos, Cynthia J, Danska, Jayne, Wang, Jean, Wouters, Bradly, Neel, Benjamin, Rottapel, Robert, Ailles, Laurie E

“…Cell surface proteins have a wide range of biological functions, and are often used as lineage-specific markers. Antibodies that recognize cell surface…”
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Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells by Ficarro, Scott B, Zhang, Yi, Lu, Yu, Moghimi, Ahmadali R, Askenazi, Manor, Hyatt, Elzbieta, Smith, Eric D, Boyer, Leah, Schlaeger, Thorsten M, Luckey, C. John, Marto, Jarrod A

“…Characterization of signaling pathways in embryonic stem cells is a prerequisite for future application of these cells to treat human disease and other…”
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Prevention of early-onset cardiomyopathy in Dmd exon 52–54 deletion mice by CRISPR-Cas9-mediated exon skipping by Rok, Matthew, Wong, Tatianna Wai Ying, Maino, Eleonora, Ahmed, Abdalla, Yang, Grace, Hyatt, Elzbieta, Lindsay, Kyle, Fatehi, Sina, Marks, Ryan, Delgado-Olguín, Paul, Ivakine, Evgueni A., Cohn, Ronald D.

“…Duchenne muscular dystrophy (DMD) is a disease with a life-threatening trajectory resulting from mutations in the dystrophin gene, leading to degeneration of…”
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Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma by Karamboulas, Christina, Bruce, Jeffrey P., Hope, Andrew J., Meens, Jalna, Huang, Shao Hui, Erdmann, Natalie, Hyatt, Elzbieta, Pereira, Keira, Goldstein, David P., Weinreb, Ilan, Su, Jie, O’Sullivan, Brian, Tiedemann, Rodger, Liu, Fei-Fei, Pugh, Trevor J., Bratman, Scott V., Xu, Wei, Ailles, Laurie

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Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma by Karamboulas, Christina, Bruce, Jeffrey P, Hope, Andrew J, Meens, Jalna, Huang, Shao Hui, Erdmann, Natalie, Hyatt, Elzbieta, Pereira, Keira, Goldstein, David P, Weinreb, Ilan, Su, Jie, O'Sullivan, Brian, Tiedemann, Rodger, Liu, Fei-Fei, Pugh, Trevor J, Bratman, Scott V, Xu, Wei, Ailles, Laurie

“…Overall survival remains very poor for patients diagnosed as having head and neck squamous cell carcinoma (HNSCC). Identification of additional biomarkers and…”
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Generation and characterization of a novel mouse model of Becker Muscular Dystrophy with a deletion of exons 52 to 55 by Perillat, Lucie O M, Wong, Tatianna W Y, Maino, Eleonora, Ahmed, Abdalla, Scott, Ori, Hyatt, Elzbieta, Delgado-Olguin, Paul, Visuvanathan, Shagana, Ivakine, Evgueni A, Cohn, Ronald D

“…Becker Muscular Dystrophy (BMD) is a rare X-linked recessive neuromuscular disorder frequently caused by in-frame deletions in the DMD gene that result in the…”
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Abstract B47: Characterization of carcinoma-associated fibroblasts from head and neck squamous cell carcinoma by Pereira, Keira, Karamboulas, Christina, Hyatt, Elzbieta, Paterson, Joshua, Ailles, Laurie

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with over 350,000 deaths annually. Metastasis remains a major cause of…”
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Abstract B12: The role of stromal cells in supporting tumor-initiating cells in serous ovarian carcinoma by Hussain, Ali, Stewart, Jocelyn, Hyatt, Elzbieta, Neel, Benjamin, Ailles, Laurie

“…High grade serous ovarian carcinoma has been shown to be a highly heterogeneous disease. In vivo studies demonstrate that the tumor initiating frequency (TIF)…”
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Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma by Gedye, Craig, Sirskyj, Danylo, Lobo, Nazleen C., Meens, Jalna, Hyatt, Elzbieta, Robinette, Michael, Fleshner, Neil, Hamilton, Robert J, Kulkarni, Girish, Zlotta, Alexandre, Evans, Andrew, Finelli, Antonio, Jewett, Michael A. S., Ailles, Laurie E.

“…Rare cancer stem cells (CSC) are proposed to be responsible for tumour propagation and re-initiation and are functionally defined by identifying…”
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559. Spell Checking Nature: A Therapeutic Use of the CRISPR/Cas9 System in Duchenne Muscular Dystrophy by Wojtal, Daria, Kemaladewi, Dwi U., Malam, Zeenat, Abdullah, Sarah, Hyatt, Elzbieta, Huang, Victoria, Mouly, Vincent, Voit, Thomas, Muntoni, Francesco, Ivakine, Evgueni A., Cohn, Ronald D.

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The K/BxN mouse model of inflammatory arthritis: theory and practice by Monach, Paul, Hattori, Kimie, Huang, Haochu, Hyatt, Elzbieta, Morse, Jody, Nguyen, Linh, Ortiz-Lopez, Adriana, Wu, Hsin-Jung, Mathis, Diane, Benoist, Christophe

“…Mice expressing the KRN T cell receptor transgene and the MHC class II molecule A(g7) (K/BxN mice) develop severe inflammatory arthritis, and serum from these…”
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Cancer stem cells in head and neck squamous cell carcinoma by Karamboulas, Christina, Pereira, Keira, Hyatt, Elzbieta, Ailles, Laurie E

“…Doc number: P14…”
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Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand by Martin-Orozco, Natalia, Chen, Zhibin, Poirot, Laurent, Hyatt, Elzbieta, Chen, Andy, Kanagawa, Osami, Sharpe, Arlene, Mathis, Diane, Benoist, Christophe

“…Costimulatory signals received by diabetogenic T cells during priming by or upon secondary encounter with autoantigen are decisive in determining the outcome…”
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