Search Results - "Hwang, Woong Y."

Heritable and precise zebrafish genome editing using a CRISPR-Cas system by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Kaini, Prakriti, Sander, Jeffry D, Joung, J Keith, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…We have previously reported a simple and customizable CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided Cas9 nuclease (RGN) system…”
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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs by Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y, Tsai, Shengdar Q, Patel, Samir, Khayter, Cyd, Joung, J Keith, Sander, Jeffry D, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…Transcription activator-like effector nucleases (TALENs) are powerful new research tools that enable targeted gene disruption in a wide variety of model…”
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Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects by Marquez, Jonathan, Criscione, June, Charney, Rebekah M, Prasad, Maneeshi S, Hwang, Woong Y, Mis, Emily K, García-Castro, Martín I, Khokha, Mustafa K

“…Multipass membrane proteins have a myriad of functions, including transduction of cell-cell signals, ion transport, and photoreception. Insertion of these…”
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Xenopus : Driving the Discovery of Novel Genes in Patient Disease and Their Underlying Pathological Mechanisms Relevant for Organogenesis by Hwang, Woong Y, Marquez, Jonathan, Khokha, Mustafa K

“…Frog model organisms have been appreciated for their utility in exploring physiological phenomena for nearly a century. Now, a vibrant community of biologists…”
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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling by Hwang, Woong Y, Kostiuk, Valentyna, González, Delfina P, Lusk, C Patrick, Khokha, Mustafa K

“…Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt…”
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Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ by Jin, Youngnam N, Hwang, Woong Y, Jo, Chulman, Johnson, Gail V W

“…Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a…”
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Efficient genome editing in zebrafish using a CRISPR-Cas system by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Tsai, Shengdar Q, Sander, Jeffry D, Peterson, Randall T, Yeh, J-R Joanna, Joung, J Keith

“…A CRISPR-Cas system allows editing of the genome in zebrafish embryos. In bacteria, foreign nucleic acids are silenced by clustered, regularly interspaced,…”
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Methods for targeted mutagenesis in zebrafish using TALENs by Hwang, Woong Y., Peterson, Randall T., Yeh, Jing-Ruey Joanna

“…The transcription activator-like effector (TALE) nucleases, or TALENs, are customizable restriction enzymes that may be used to induce mutations at nearly any…”
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Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells by Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.

“…Primordial germ cells (PGCs) form during early embryogenesis with a supply of maternal mRNAs that contain shorter poly(A) tails. How translation of maternal…”
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Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Gonzales, Andrew P W, Joung, J Keith, Yeh, Jing-Ruey Joanna

“…In recent years, the zebrafish has become a critical contributor to various areas of biomedical research, advancing our fundamental understanding of…”
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Noncanonical translation via deadenylated 3′ UTRs maintains primordial germ cells by Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.

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Kap-[beta]2/Transportin mediates [beta]-catenin nuclear transport in Wnt signaling by Hwang, Woong Y, Kostiuk, Valentyna, González, Delfina P, Lusk, C Patrick, Khokha, Mustafa K

“…Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt…”
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Non-canonical translation via deadenylated 3′UTRs maintains primordial germ cells by Jin, Youngnam N., Schlueter, Peter J., Jurisch-Yaksi, Nathalie, Lam, Pui-Ying, Jin, Shan, Hwang, Woong Y., Yeh, Jing-Ruey Joanna, Yoshigi, Masaaki, Ong, Shao-En, Schenone, Monica, Hartigan, Christina R., Carr, Steven A., Peterson, Randall T.

“…Primordial germ cells (PGCs) form during early embryogenesis with a supply of maternal mRNAs that contain shorter poly(A)-tails. How translation of maternal…”
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Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPAR[gamma] by Jin, Youngnam N, Hwang, Woong Y, Jo, Chulman, Johnson, Gail V. W

“…Impairments in mitochondria and transcription are important factors in the pathogenesis of Huntington disease (HD), a neurodegenerative disease caused by a…”
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Efficient In Vivo Genome Editing Using RNA-Guided Nucleases by Hwang, Woong Y., Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L., Tsai, Shengdar Q., Sander, Jeffry D., Peterson, Randall T., Yeh, J.-R. Joanna, Joung, J. Keith

“…Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems have evolved in bacteria and archaea as a defense mechanism…”
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