Search Results - "Hwang, Woong"

Heritable and precise zebrafish genome editing using a CRISPR-Cas system by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Kaini, Prakriti, Sander, Jeffry D, Joung, J Keith, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…We have previously reported a simple and customizable CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided Cas9 nuclease (RGN) system…”
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Redox regulation of SIRT1 in inflammation and cellular senescence by Hwang, Jae-woong, Yao, Hongwei, Caito, Samuel, Sundar, Isaac K., Rahman, Irfan

“…Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie restriction/energetics, mitochondrial biogenesis, stress resistance,…”
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Efficient genome editing in zebrafish using a CRISPR-Cas system by Hwang, Woong Y, Fu, Yanfang, Reyon, Deepak, Maeder, Morgan L, Tsai, Shengdar Q, Sander, Jeffry D, Peterson, Randall T, Yeh, J-R Joanna, Joung, J Keith

“…A CRISPR-Cas system allows editing of the genome in zebrafish embryos. In bacteria, foreign nucleic acids are silenced by clustered, regularly interspaced,…”
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice by Yao, Hongwei, Chung, Sangwoon, Hwang, Jae-woong, Rajendrasozhan, Saravanan, Sundar, Isaac K, Dean, David A, McBurney, Michael W, Guarente, Leonard, Gu, Wei, Rönty, Mikko, Kinnula, Vuokko L, Rahman, Irfan

“…Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1…”
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Regulation of SIRT1 in cellular functions: Role of polyphenols by Chung, Sangwoon, Yao, Hongwei, Caito, Samuel, Hwang, Jae-woong, Arunachalam, Gnanapragasam, Rahman, Irfan

“…Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance,…”
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Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway by Hwang, Jae‐Woong, Sundar, Isaac K., Yao, Hongwei, Sellix, Michael T., Rahman, Irfan

“…Patients with obstructive lung diseases display abnormal circadian rhythms in lung function. We determined the mechanism whereby environmental…”
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Five-year evaluation of the influence of keratinized mucosa on peri-implant soft-tissue health and stability around implants supporting full-arch mandibular fixed prostheses by Schrott, Alexander René, Jimenez, Monik, Hwang, Jae-Woong, Fiorellini, Joseph, Weber, Hans-Peter

“…Background: The question of the importance of keratinized mucosa around dental implants for the prevention of peri‐implant disease could not be answered in the…”
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Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs by Cade, Lindsay, Reyon, Deepak, Hwang, Woong Y, Tsai, Shengdar Q, Patel, Samir, Khayter, Cyd, Joung, J Keith, Sander, Jeffry D, Peterson, Randall T, Yeh, Jing-Ruey Joanna

“…Transcription activator-like effector nucleases (TALENs) are powerful new research tools that enable targeted gene disruption in a wide variety of model…”
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The influence of alkali activators on the properties of ternary blended cement incorporated with ferronickel slag by Jae Kim, Min, Ik Hwang, Woong, Jung Cho, Won

“…•The setting time and adiabatic temperature of binary and ternary blended cement mixed with FNS or/and PFA was assessed.•The hydration in blended cement with…”
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Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects by Marquez, Jonathan, Criscione, June, Charney, Rebekah M, Prasad, Maneeshi S, Hwang, Woong Y, Mis, Emily K, García-Castro, Martín I, Khokha, Mustafa K

“…Multipass membrane proteins have a myriad of functions, including transduction of cell-cell signals, ion transport, and photoreception. Insertion of these…”
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Xenopus : Driving the Discovery of Novel Genes in Patient Disease and Their Underlying Pathological Mechanisms Relevant for Organogenesis by Hwang, Woong Y, Marquez, Jonathan, Khokha, Mustafa K

“…Frog model organisms have been appreciated for their utility in exploring physiological phenomena for nearly a century. Now, a vibrant community of biologists…”
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Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM by Yao, Hongwei, Arunachalam, Gnanapragasam, Hwang, Jae-woong, Chung, Sangwoon, Sundar, saac K., Kinnula, Vuokko L., Crapo, James D., Rahman, Irfan, Fridovich, Irwin

“…Extracellular superoxide dismutase (ECSOD or SOD3) is highly expressed in lungs and functions as a scavenger of O 2 • − . ECM fragmentation, which can be…”
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Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR by Sempou, Emily, Kostiuk, Valentyna, Zhu, Jie, Cecilia Guerra, M., Tyan, Leonid, Hwang, Woong, Camacho-Aguilar, Elena, Caplan, Michael J., Zenisek, David, Warmflash, Aryeh, Owens, Nick D. L., Khokha, Mustafa K.

“…Transitioning from pluripotency to differentiated cell fates is fundamental to both embryonic development and adult tissue homeostasis. Improving our…”
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FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease by Hwang, Jae-woong, Rajendrasozhan, Saravanan, Yao, Hongwei, Chung, Sangwoon, Sundar, Isaac K, Huyck, Heidie L, Pryhuber, Gloria S, Kinnula, Vuokko L, Rahman, Irfan

“…Forkhead box class O 3a (FOXO3) is a member of the FoxO transcription factor subfamily, which regulates the expression of target genes not only through DNA…”
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Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD by Hwang, Jae-woong, Chung, Sangwoon, Sundar, Isaac K., Yao, Hongwei, Arunachalam, Gnanapragasam, McBurney, Michael W., Rahman, Irfan

“…Autophagy is a fundamental cellular process that eliminates long-lived proteins and damaged organelles through lysosomal degradation pathway. Cigarette smoke…”
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Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling by Hwang, Woong Y, Kostiuk, Valentyna, González, Delfina P, Lusk, C Patrick, Khokha, Mustafa K

“…Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt…”
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Methods for targeted mutagenesis in zebrafish using TALENs by Hwang, Woong Y., Peterson, Randall T., Yeh, Jing-Ruey Joanna

“…The transcription activator-like effector (TALE) nucleases, or TALENs, are customizable restriction enzymes that may be used to induce mutations at nearly any…”
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Author Correction: Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR by Sempou, Emily, Kostiuk, Valentyna, Zhu, Jie, Cecilia Guerra, M., Tyan, Leonid, Hwang, Woong, Camacho-Aguilar, Elena, Caplan, Michael J., Zenisek, David, Warmflash, Aryeh, Owens, Nick D. L., Khokha, Mustafa K.

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Aronia melanocarpa and its components demonstrate antiviral activity against influenza viruses by Park, Sehee, Kim, Jin Il, Lee, Ilseob, Lee, Sangmoo, Hwang, Min-Woong, Bae, Joon-Yong, Heo, Jun, Kim, Donghwan, Han, Sang-Zin, Park, Man-Seong

“…•Broad-spectrum antivirals can effectively control influenza burdens.•Aronia exhibited virucidal activity against various influenza viruses.•Mainly acting on…”
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SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD by Yao, Hongwei, Hwang, Jae-woong, Sundar, Isaac K, Friedman, Alan E, McBurney, Michael W, Guarente, Leonard, Gu, Wei, Kinnula, Vuokko L, Rahman, Irfan

“…Sirtuin1 (SIRT1), a protein/histone deacetylase, protects against the development of pulmonary emphysema. However, the molecular mechanisms underlying this…”
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