Search Results - "Hwang, Sun‐Hee"

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins by Badgandi, Hemant B, Hwang, Sun-Hee, Shimada, Issei S, Loriot, Evan, Mukhopadhyay, Saikat

“…The primary cilium is a paradigmatic organelle for studying compartmentalized signaling; however, unlike soluble protein trafficking, processes targeting…”
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Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis by Hwang, Sun-Hee, White, Kevin Andrew, Somatilaka, Bandarigoda Nipunika, Wang, Baolin, Mukhopadhyay, Saikat

“…A fundamental problem in tissue morphogenesis is identifying how subcellular signaling regulates mesoscale organization of tissues. The primary cilium is a…”
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The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner by Hwang, Sun-Hee, White, Kevin A, Somatilaka, Bandarigoda N, Shelton, John M, Richardson, James A, Mukhopadhyay, Saikat

“…The role of basal suppression of the sonic hedgehog (Shh) pathway and its interaction with Indian hedgehog (Ihh) signaling during limb/skeletal morphogenesis…”
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Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner by Hwang, Sun-Hee, Somatilaka, Bandarigoda N, White, Kevin, Mukhopadhyay, Saikat

“…The role of compartmentalized signaling in primary cilia during tissue morphogenesis is not well understood. The cilia localized G protein-coupled receptor,…”
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Trafficking to the primary cilium membrane by Mukhopadhyay, Saikat, Badgandi, Hemant B, Hwang, Sun-Hee, Somatilaka, Bandarigoda, Shimada, Issei S, Pal, Kasturi

“…The primary cilium has been found to be associated with a number of cellular signaling pathways, such as vertebrate hedgehog signaling, and implicated in the…”
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B Cell–Specific Deletion of CR6‐Interacting Factor 1 Drives Lupus‐like Autoimmunity by Activation of Interleukin‐17, Interleukin‐6, and Pathogenic Follicular Helper T Cells in a Mouse Model by Park, Jin‐Sil, Yang, SeungCheon, Hwang, Sun‐Hee, Choi, JeongWon, Kwok, Seung‐Ki, Kong, Young‐Yun, Youn, Jeehee, Cho, Mi‐La, Park, Sung‐Hwan

“…Objective CR6‐interacting factor 1 (CRIF1) is a nuclear transcriptional regulator and a mitochondrial inner membrane protein; however, its functions in B…”
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EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis by Park, Jin-Sil, Yang, Seung Cheon, Jeong, Ha Yeon, Lee, Seon-Young, Ryu, Jun-Geol, Choi, Jeong Won, Kang, Hye Yeon, Kim, Sung-Min, Hwang, Sun-Hee, Cho, Mi-La, Park, Sung-Hwan

“…EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have…”
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Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer by Jung, Yoon Ju, Woo, Jin Seok, Hwang, Sun-Hee, Yang, SeungCheon, Kim, So Jung, Jhun, JooYeon, Lee, Seung Yoon, Lee, Kun Hee, Cho, Mi-La, Song, Kyo Young

“…BackgroundInterleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote tumor growth by…”
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Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway by Woo, Jin Seok, Hwang, Sun-Hee, Yang, SeungCheon, Lee, Kun Hee, Lee, Yeon Su, Choi, Jeong Won, Park, Jin-Sil, Jhun, JooYeon, Park, Sung-Hwan, Cho, Mi-La

“…Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS…”
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Metabolic abnormalities exacerbate Sjögren's syndrome by and is associated with increased the population of interleukin-17-producing cells in NOD/ShiLtJ mice by Hwang, Sun-Hee, Park, Jin-Sil, Yang, SeungCheon, Jung, Kyung-Ah, Choi, JeongWon, Kwok, Seung-Ki, Park, Sung-Hwan, Cho, Mi-La

“…Sjögren's syndrome (SS) is an autoimmune disease mediated by lymphocytic infiltration into exocrine glands, resulting in progressive lacrimal and salivary…”
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Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis by Shimada, Issei S., Hwang, Sun-Hee, Somatilaka, Bandarigoda N., Wang, Xin, Skowron, Patryk, Kim, Jiwoong, Kim, Min, Shelton, John M., Rajaram, Veena, Xuan, Zhenyu, Taylor, Michael D., Mukhopadhyay, Saikat

“…Sonic hedgehog (Shh) determines cerebellar granule cell (GC) progenitor proliferation and medulloblastoma pathogenesis. However, the pathways regulating GC…”
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Gut microbiome-derived butyrate inhibits the immunosuppressive factors PD-L1 and IL-10 in tumor-associated macrophages in gastric cancer by Lee, Seung Yoon, Jhun, JooYeon, Woo, Jin Seok, Lee, Kun Hee, Hwang, Sun-Hee, Moon, Jeonghyeon, Park, Goeun, Choi, Sun Shim, Kim, So Jung, Jung, Yoon Ju, Song, Kyo Young, Cho, Mi-La

“…Early detection and surgical treatment are essential to achieve a good outcome in gastric cancer (GC). Stage IV and recurrent GC have a poor prognosis…”
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B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice by Hwang, Sun-Hee, Lee, Huiyin, Yamamoto, Miwako, Jones, Leigh A, Dayalan, Jivanaah, Hopkins, Richard, Zhou, Xin J, Yarovinsky, Felix, Connolly, John E, Curotto de Lafaille, Maria A, Wakeland, Edward K, Fairhurst, Anna-Marie

“…Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by the production of antinuclear autoantibodies. Antinuclear…”
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G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning by Hwang, Sun-Hee, Mukhopadhyay, Saikat

“…The primary cilium is critical in sonic hedgehog (Shh)‐dependent ventral patterning of the vertebrate neural tube. Most mutants that cause disruption of the…”
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Yaa autoimmune phenotypes are conferred by overexpression of TLR7 by Fairhurst, Anna-Marie, Hwang, Sun-hee, Wang, Andrew, Tian, Xiang-Hong, Boudreaux, Christopher, Zhou, Xin J, Casco, Jose, Li, Quan-Zhen, Connolly, John E, Wakeland, Edward K

“…The Y-linked autoimmune accelerating (Yaa) locus drives the transition to fatal lupus nephritis when combined with B6.Sle1 in our C57BL/6J (B6)-congenic model…”
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RNA sensing by conventional dendritic cells is central to the development of lupus nephritis by Celhar, Teja, Hopkins, Richard, Thornhill, Susannah I., De Magalhaes, Raquel, Hwang, Sun-Hee, Lee, Hui-Yin, Yasuga, Hiroko, Jones, Leigh A., Casco, Jose, Lee, Bernett, Thamboo, Thomas P., Zhou, Xin J., Poidinger, Michael, Connolly, John E., Wakeland, Edward K., Fairhurst, Anna-Marie

“…Glomerulonephritis is a common and debilitating feature of systemic lupus erythematosus (SLE). The precise immune mechanisms that drive the progression from…”
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IL-17 and CCR9 + α4β7 - Th17 Cells Promote Salivary Gland Inflammation, Dysfunction, and Cell Death in Sjögren's Syndrome by Hwang, Sun-Hee, Woo, Jin Seok, Moon, Jeonghyeon, Yang, SeungCheon, Park, Jin-Sil, Lee, JaeSeon, Choi, JeongWon, Lee, Kun Hee, Kwok, Seung-Ki, Park, Sung-Hwan, Cho, Mi-La

“…Previous studies have evaluated the roles of T and B cells in the pathogenesis of Sjögren's syndrome (SS); however, their relationships with age-dependent and…”
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CR6‐interacting factor 1 controls autoimmune arthritis by regulation of signal transducer and activator of transcription 3 pathway and T helper type 17 cells by Park, Jin‐Sil, Choi, Si‐Young, Hwang, Sun‐Hee, Kim, Sung‐Min, Choi, JeongWon, Jung, Kyung‐Ah, Kwon, Ji Ye, Kong, Young‐Yun, Cho, Mi‐La, Park, Sung‐Hwan

“…Summary CR6‐interacting factor 1 (CRIF1) is a nuclear protein that interacts with other nuclear factors and androgen receptors, and is implicated in the…”
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A bispecific soluble receptor fusion protein that targets TNF‐α and IL‐21 for synergistic therapy in inflammatory arthritis by Park, Jin‐Sil, Yoo, Seok‐Ho, Lim, Mi‐Ae, Ryu, Jun‐Geol, Oh, Hye‐Joa, Hwang, Sun‐Hee, Yang, SeungCheon, Jung, Kyung‐Ah, Yoon, Sunha, Park, Bum‐Chan, Park, Sung‐Hwan, Kim, Ho‐Youn, Cho, Mi‐La, Park, Young‐woo

“…This study was aimed at investigating the therapeutic effects of BITRAP, a bispecific fusion protein targeting TNF‐α and IL‐21, on the development of…”
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Metformin-Inducible Small Heterodimer Partner Interacting Leucine Zipper Protein Ameliorates Intestinal Inflammation by Yang, SeungCheon, Park, Jin-Sil, Hwang, Sun-Hee, Cho, Keun-Hyung, Choi, JeongWon, Jhun, Jooyeon, Kim, Seung-Jun, Lee, Bo-In, Park, Sung-Hwan, Cho, Mi-La

“…Small heterodimer partner interacting leucine zipper protein (SMILE) is an orphan nuclear receptor and a member of the bZIP family of proteins. We investigated…”
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