Search Results - "Hwang, Peter K"

The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable by Benod, Cindy, Villagomez, Rosa, Filgueira, Carly S, Hwang, Peter K, Leonard, Paul G, Poncet-Montange, Guillaume, Rajagopalan, Senapathy, Fletterick, Robert J, Gustafsson, Jan-Åke, Webb, Paul

“…Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a…”
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Conformation Switching of Clathrin Light Chain Regulates Clathrin Lattice Assembly by Wilbur, Jeremy D., Hwang, Peter K., Ybe, Joel A., Lane, Michael, Sellers, Benjamin D., Jacobson, Matthew P., Fletterick, Robert J., Brodsky, Frances M.

“…Clathrin-coated vesicle formation is responsible for membrane traffic to and from the endocytic pathway during receptor-mediated endocytosis and organelle…”
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Actin Binding by Hip1 (Huntingtin-interacting Protein 1) and Hip1R (Hip1-related Protein) Is Regulated by Clathrin Light Chain by Wilbur, Jeremy D., Chen, Chih-Ying, Manalo, Venus, Hwang, Peter K., Fletterick, Robert J., Brodsky, Frances M.

“…The huntingtin-interacting protein family members (Hip1 and Hip1R in mammals and Sla2p in yeast) link clathrin-mediated membrane traffic to actin cytoskeleton…”
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Use of intracranial and ocular thermography before and after arteriovenous malformation excision by Hwang, Peter Y. K, Lewis, Philip M, Maller, Jerome J

“…Excision of arteriovenous malformations (AVMs) is known to carry a risk of postoperative hemorrhage, postulated to be the result of normal perfusion pressure…”
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Minimally invasive carpal tunnel decompression using the KnifeLight: How I Do It by Lee, Shi Qing, Hwang, Peter Y. K.

“…Background Carpal tunnel decompression is commonly performed open or endoscopically. Carpal tunnel release using the KnifeLight instrument (Stryker, Kalamazoo,…”
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Surgical planning for microsurgical excision of cerebral arterio-venous malformations using virtual reality technology by Ng, Ivan, Hwang, Peter Y. K., Kumar, Dinesh, Lee, Cheng Kiang, Kockro, Ralf A., Sitoh, Y. Y.

“…Background To evaluate the feasibility of surgical planning using a virtual reality platform workstation in the treatment of cerebral arterio-venous…”
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A Dimer-Specific Function of the Transcription Factor NFATp by Falvo, James V., Lin, Charles H., Tsytsykova, Alla V., Hwang, Peter K., Thanos, Dimitris, Goldfeld, Anne E., Maniatis, Tom

“…The transcription factor NFATp integrates multiple signal transduction pathways through coordinate binding with basic-region leucine zipper (bZIP) proteins and…”
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The epidemiology of BCVI at a single state trauma centre by Hwang, Peter Y.K, Lewis, Philip M, Balasubramani, Yagnesh V, Madan, Anoop, Rosenfeld, Jeffrey V

“…Abstract Background Blunt carotid and vertebral artery injury (BCVI) is a relatively uncommon but potentially devastating injury. The aim of our study was to…”
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New Faces of the Familiar Clathrin Lattice by Wilbur, Jeremy D., Hwang, Peter K., Brodsky, Frances M.

“…The clathrin triskelion self‐assembles into a lattice that coats transport vesicles participating in several key membrane traffic pathways. A new model of a…”
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Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain by Wilbur, Jeremy D., Hwang, Peter K., Brodsky, Frances M., Fletterick, Robert J.

“…Huntingtin‐interacting protein 1 (HIP1) is an important link between the actin cytoskeleton and clathrin‐mediated endocytosis machinery. HIP1 has also been…”
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Clathrin self-assembly is mediated by a tandemly repeated superhelix by Ybe, Joel A, Brodsky, Frances M, Hofmann, Kay, Lin, Kai, Liu, Shu-Hui, Chen, Lin, Earnest, Thomas N, Fletterick, Robert J, Hwang, Peter K

“…Clathrin is a triskelion-shaped cytoplasmic protein that polymerizes into a polyhedral lattice on intracellular membranes to form protein-coated membrane…”
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Flexible antibodies with nonprotein hinges by CAPON, Daniel J., KANEKO, Naoki, YOSHIMORI, Takayuki, SHIMADA, Takashi, WURM, Florian M., HWANG, Peter K., TONG, Xiaohe, ADAMS, Staci A., SIMMONS, Graham, SATO, Taka-Aki, TANAKA, Koichi

“…There is a significant need for antibodies that can bind targets with greater affinity. Here we describe a novel strategy employing chemical semisynthesis to…”
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A Protein Phosphorylation Switch at the Conserved Allosteric Site in GP by Lin, Kai, Rath, Virginia L., Dai, Shirleko C., Fletterick, Robert J., Hwang, Peter K.

“…A phosphorylation-initiated mechanism of local protein refolding activates yeast glycogen phosphorylase (GP). Refolding of the phosphorylated amino-terminus…”
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Topical papaverine as rescue therapy for vasospasm complicated by unsecured aneurysm by Praeger, Adrian J, Lewis, Philip M, Hwang, Peter Y K

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Novel Binding Sites on Clathrin and Adaptors Regulate Distinct Aspects of Coat Assembly by Knuehl, Christine, Chen, Chih‐Ying, Manalo, Venus, Hwang, Peter K., Ota, Nobuyuki, Brodsky, Frances M.

“…Clathrin‐coated vesicles (CCVs) sort proteins at the plasma membrane, endosomes and trans Golgi network for multiple membrane traffic pathways. Clathrin…”
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Neurosurgical management of intracranial aneurysms following unsuccessful or incomplete endovascular therapy by Minh, Tran, Hwang, Peter Y. K, Nguyen, Kim Chung, Ng, Ivan

“…The publication of the ISAT trial in 2002 has resulted in increasing numbers of patients with aneurysmal subarachnoid haemorrhage undergoing endovascular…”
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Postoperative intracranial haemorrhage: a review by Seifman, Marc A., Lewis, Phillip M., Rosenfeld, Jeffrey V., Hwang, Peter Y. K.

“…Postoperative haemorrhage (POH) is one of the most serious complications of any cranial neurosurgical procedure and is associated with significant morbidity…”
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Virtual temporal bone: an interactive 3-dimensional learning aid for cranial base surgery by Kockro, Ralf A, Hwang, Peter Y K

“…We have developed an interactive virtual model of the temporal bone for the training and teaching of cranial base surgery. The virtual model was based on the…”
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Clathrin self-assembly involves coordinated weak interactions favorable for cellular regulation by Brodsky, Frances M, Wakeham, Diane E, Chen, Chih-Ying, Greene, Barrie, Hwang, Peter K

“…The clathrin triskelion self‐assembles into a polyhedral coat surrounding membrane vesicles that sort receptor cargo to the endocytic pathway. A triskelion…”
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Clathrin light and heavy chain interface: α-helix binding superhelix loops via critical tryptophans by Chen, Chih-Ying, Reese, Michael L., Hwang, Peter K., Ota, Nobuyuki, Agard, David, Brodsky, Frances M.

“…Clathrin light chain subunits (LCa and LCb) contribute to regulation of coated vesicle formation to sort proteins during receptor‐mediated endocytosis and…”
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