Search Results - "Hwang, Injeoung"

Novel 2,6,9-Trisubstituted Purines as Potent CDK Inhibitors Alleviating Trastuzumab-Resistance of HER2-Positive Breast Cancers by Kuchukulla, Ratnakar Reddy, Hwang, Injeoung, Park, Sang Won, Moon, Sojeong, Kim, Suhn Hyung, Kim, Sumin, Chung, Hwan Won, Ji, Mi-Jung, Park, Hyun-Mee, Kong, Gu, Hur, Wooyoung

“…HER2-positive (HER2+) breast cancer is defined by HER2 oncogene amplification on chromosome 17q12 and accounts for 15−20% population of breast-cancer patients…”
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Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo by Kuchukulla, Ratnakar Reddy, Hwang, Injeoung, Kim, Suhn Hyung, Kye, Younghyeon, Park, Narae, Cha, Heary, Moon, Sojeong, Chung, Hwan Won, Lee, Cheolju, Kong, Gu, Hur, Wooyoung

“…CDK12 is overexpressed in HER2-positive breast cancers and promotes tumorigenesis and trastuzumab resistance. Thus CDK12 is a good therapeutic target for the…”
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Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain by Kim, Sumin, Hwang, Injeoung, Kim, Suhn Hyung, Chung, Hwan Won, Ji, Mi‐Jung, Moon, Sojeong, Park, Hyun‐Mee, Kong, Gu, Hur, Wooyoung

“…NSD3/WHSC1L1 lysine methyltransferase promotes the transcription of target genes through di‐ or tri‐methylation at histone H3K36 using SAM as a cofactor…”
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Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A by Lee, Hyomin, Kim, Euijung, Hwang, Narae, Yoo, Jesik, Nam, Yunju, Hwang, Injeoung, Park, Jin-Gyeong, Park, Sang-Eun, Chung, Kyung-Sook, Won Chung, Hwan, Song, Chiman, Ji, Mi-Jung, Park, Hyun-Mee, Lee, In-Kyun, Lee, Kyung-Tae, Joo Roh, Eun, Hur, Wooyoung

“…[Display omitted] •Novel AurkA allosteric inhibitors of N-benzylbenzamide backbone were designed and synthesized.•The most potent analogue 6h (AurkA…”
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