Search Results - "Hwang, Inhwa"

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration by Lee, Eunju, Hwang, Inhwa, Park, Sangjun, Hong, Sujeong, Hwang, Boreum, Cho, Yoeseph, Son, Junghyun, Yu, Je-Wook

“…Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the…”
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SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease by Kim, So Ra, Lee, Sang-Guk, Kim, Soo Hyun, Kim, Jin Hee, Choi, Eunhye, Cho, Wonhee, Rim, John Hoon, Hwang, Inhwa, Lee, Chan Joo, Lee, Minyoung, Oh, Chang-Myung, Jeon, Justin Y., Gee, Heon Yung, Kim, Jeong-Ho, Lee, Byung-Wan, Kang, Eun Seok, Cha, Bong-Soo, Lee, Myung-Shik, Yu, Je-Wook, Cho, Jin Won, Kim, Jung-Sun, Lee, Yong-ho

“…Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular events in humans with type 2 diabetes (T2D); however, the underlying mechanism remains…”
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Defective mitochondrial fission augments NLRP3 inflammasome activation by Park, Sangjun, Won, Ji-Hee, Hwang, Inhwa, Hong, Sujeong, Lee, Heung Kyu, Yu, Je-Wook

“…Despite the fact that deregulated NLRP3 inflammasome activation contributes to the pathogenesis of chronic inflammatory or metabolic disorders, the underlying…”
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Advanced glycation end products impair NLRP3 inflammasome–mediated innate immune responses in macrophages by Son, Seunghwan, Hwang, Inhwa, Han, Seung Hyeok, Shin, Jeon-Soo, Shin, Ok Sarah, Yu, Je-Wook

“…Advanced glycation end products (AGEs) are adducts formed on proteins by glycation with reducing sugars, such as glucose, and tend to form and accumulate under…”
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25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome by Jang, Jiho, Park, Sangjun, Jin Hur, Hye, Cho, Hyun-Ju, Hwang, Inhwa, Pyo Kang, Yun, Im, Isak, Lee, Hyunji, Lee, Eunju, Yang, Wonsuk, Kang, Hoon-Chul, Won Kwon, Sung, Yu, Je-Wook, Kim, Dong-Wook

“…X-linked adrenoleukodystrophy (X-ALD), caused by an ABCD1 mutation, is a progressive neurodegenerative disorder associated with the accumulation of very…”
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Histone deacetylase 6 negatively regulates NLRP3 inflammasome activation by Hwang, Inhwa, Lee, Eunju, Jeon, Seon-A, Yu, Je-Wook

“…Emerging reports demonstrate that deregulated NLRP3 inflammasome activation is implicated in a variety of inflammatory and metabolic disorders, but the…”
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Bacterial Outer Membrane Vesicle-Mediated Cytosolic Delivery of Flagellin Triggers Host NLRC4 Canonical Inflammasome Signaling by Yang, Jungmin, Hwang, Inhwa, Lee, Eunju, Shin, Sung Jae, Lee, Eun-Jin, Rhee, Joon Haeng, Yu, Je-Wook

“…Bacteria-released components can modulate host innate immune response in the absence of direct host cell-bacteria interaction. In particular, bacteria-derived…”
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Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa by Oh, Ji Eun, Kim, Byoung-Chan, Chang, Dong-Ho, Kwon, Meehyang, Lee, Sun Young, Kang, Dukjin, Kim, Jin Young, Hwang, Inhwa, Yu, Je-Wook, Nakae, Susumu, Lee, Heung Kyu

“…Commensal microbiota are well known to play an important role in antiviral immunity by providing immune inductive signals; however, the consequence of…”
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SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models by Kwon, Oh‐Chan, Song, Jae‐Jin, Yang, Yunseon, Kim, Seong‐Hoon, Kim, Ji Young, Seok, Min‐Jong, Hwang, Inhwa, Yu, Je‐Wook, Karmacharya, Jenisha, Maeng, Han‐Joo, Kim, Jiyoung, Jho, Eek‐hoon, Ko, Seung Yeon, Son, Hyeon, Chang, Mi‐Yoon, Lee, Sang‐Hun

“…Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory environments in disease contexts and thereby contribute to the…”
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Hyperglycemia enhances brain susceptibility to lipopolysaccharide-induced neuroinflammation via astrocyte reprogramming by Lee, Kyung-Seo, Yoon, Sung-Hyun, Hwang, Inhwa, Ma, Jeong-Hwa, Yang, Euimo, Kim, Rebekah Hyeyoon, Kim, Eosu, Yu, Je-Wook

“…Hyperglycemia has been shown to modulate the immune response of peripheral immune cells and organs, but the impact of hyperglycemia on neuroinflammation within…”
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Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu by Son, Seunghwan, Yoon, Sung-Hyun, Chae, Byeong Jun, Hwang, Inhwa, Shim, Do-Wan, Choe, Young Ho, Hyun, Young-Min, Yu, Je-Wook

“…Aberrant inflammasome activation contributes to various chronic inflammatory diseases; however, pyroptosis of inflammasome-active cells promptly terminates…”
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Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation by Son, Seunghwan, Shim, Do-Wan, Hwang, Inhwa, Park, Jong-Hwan, Yu, Je-Wook

“…Paclitaxel is a chemotherapeutic drug commonly used to treat different types of cancer. In addition to its antitumor effect, paclitaxel is also known to…”
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Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis by Shim, Do-Wan, Eo, Jun-Cheol, Kim, Saeyoung, Hwang, Inhwa, Nam, BoYoung, Shin, Jae-Eun, Han, Seung Hyeok, Yu, Je-Wook

“…Circadian arrhythmia has been linked to increased susceptibility to multiple inflammatory diseases, such as sepsis. However, it remains unclear how disruption…”
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Extracellular Acidification Augments NLRP3-Mediated Inflammasome Signaling in Macrophages by Chae, Byeong Jun, Lee, Kyung-Seo, Hwang, Inhwa, Yu, Je-Wook

“…Inflammation is a series of host defense processes in response to microbial infection and tissue injury. Inflammatory processes frequently cause extracellular…”
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Intracellular NAD + Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation by Shim, Do-Wan, Cho, Hyo-Joung, Hwang, Inhwa, Jung, Taek-Yeol, Kim, Hyun-Seok, Ryu, Ju Hee, Yu, Je-Wook

“…Nicotinamide adenine dinucleotide (NAD ) is an important cofactor in many redox and non-redox NAD -consuming enzyme reactions. Intracellular NAD level steadily…”
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Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model by Ma, Ji-Hyun, Lee, Eunju, Yoon, Sung-Hyun, Min, Hyehyun, Oh, Jae Hwan, Hwang, Inhwa, Sung, Yejin, Ryu, Ju Hee, Bok, Jinwoong, Yu, Je-Wook

“…Cryopyrin-associated periodic syndrome (CAPS) is an inherited autoinflammatory disease caused by a gain-of-function mutation in NLRP3. Although CAPS patients…”
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Palmitate and minimally-modified low-density lipoprotein cooperatively promote inflammatory responses in macrophages by Ann, Soo-Jin, Kim, Ka-Kyung, Cheon, Eun Jeong, Noh, Hye-Min, Hwang, Inhwa, Yu, Je-Wook, Park, Sungha, Kang, Seok-Min, Manabe, Ichiro, Miller, Yury I, Kim, Sangwoo, Lee, Sang-Hak

“…Increased consumption of Western-type diets and environmental insults lead to wide-spread increases in the plasma levels of saturated fatty acids and…”
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Role of type Ⅰ interferon signaling in kainic acid-induced seizure model by Ma, Jeong-Hwa, Hwang, Inhwa, Yu, Je-Wook

“…Abstract Type Ⅰ interferon (IFN) signaling has emerged as a significant factor in brain development and homeostasis. Also, its dysregulation has been…”
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Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures by Kim, Eun-Hee, Won, Ji-Hee, Hwang, Inhwa, Yu, Je-Wook

“…Hypoxia has been shown to promote inflammation, including the release of proinflammatory cytokines, but it is poorly investigated how hypoxia directly affects…”
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The mitochondrial antiviral protein MAVS associates with NLRP3 and regulates its inflammasome activity by Park, Sangjun, Juliana, Christine, Hong, Sujeong, Datta, Pinaki, Hwang, Inhwa, Fernandes-Alnemri, Teresa, Yu, Je-Wook, Alnemri, Emad S

“…NLRP3 assembles an inflammasome complex that activates caspase-1 upon sensing various danger signals derived from pathogenic infection, tissue damage, and…”
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