Search Results - "Hwang, Inah"

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification by Hwang, Inah, Uchida, Hiroki, Dai, Ziwei, Li, Fei, Sanchez, Teresa, Locasale, Jason W., Cantley, Lewis C., Zheng, Hongwu, Paik, Jihye

“…Neural stem/progenitor cells (NSPCs) persist over the lifespan while encountering constant challenges from age or injury related brain environmental changes…”
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Peroxiredoxin 3 deficiency accelerates chronic kidney injury in mice through interactions between macrophages and tubular epithelial cells by Hwang, Inah, Uddin, Md Jamal, Lee, Gayoung, Jiang, Songling, Pak, Eun Seon, Ha, Hunjoo

“…Chronic kidney disease (CKD) has become epidemic worldwide. Mitochondrial reactive oxygen species (ROS)-induced oxidative stress is an important mediator of…”
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The impaired redox balance in peroxisomes of catalase knockout mice accelerates nonalcoholic fatty liver disease through endoplasmic reticulum stress by Hwang, Inah, Uddin, Md Jamal, Pak, Eun Seon, Kang, Hyeji, Jin, Eun-Jung, Jo, Suin, Kang, Dongmin, Lee, Hyukjin, Ha, Hunjoo

“…Peroxisomes are essential organelles for maintaining the homeostasis of lipids and reactive oxygen species (ROS). While oxidative stress-induced endoplasmic…”
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Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction by HWANG, Inah, LEE, Jiyoun, JOO YOUNG HUH, PARK, Jehyun, HI BAHL LEE, HO, Ye-Shih, HA, Hunjoo

“…Mitochondrial reactive oxygen species (ROS) play an important role in diabetes complications, including diabetic nephropathy (DN). Plasma free fatty acids…”
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Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action by Park, Jong Hee, Hwang, Inah, Hwang, Soo Han, Han, Hoon, Ha, Hunjoo

“…Abstract Aims The present study examined renoprotective effect of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) in diabetes. NRK-52E…”
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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance by Li, Fei, Wang, Yizhe, Hwang, Inah, Jang, Ja-Young, Xu, Libo, Deng, Zhong, Yu, Eun Young, Cai, Yiming, Wu, Caizhi, Han, Zhenbo, Huang, Yu-Han, Huang, Xiangao, Zhang, Ling, Yao, Jun, Lue, Neal F., Lieberman, Paul M., Ying, Haoqiang, Paik, Jihye, Zheng, Hongwu

“…Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% − 10% of human cancers rely on a recombination-based mechanism…”
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CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways by Im, Joo-Young, Kim, Soo Jin, Park, Jong-Lyul, Han, Tae-Hee, Kim, Woo-il, Kim, Inhyub, Ko, Bomin, Chun, So-Young, Kang, Mi-Jung, Kim, Bo-Kyung, Jeon, Sol A., Kim, Seon-Kyu, Ryu, Incheol, Kim, Seon-Young, Nam, Ki-Hoan, Hwang, Inah, Ban, Hyun Seung, Won, Misun

“…Cytochrome b5 reductase 3 (CYB5R3) is involved in various cellular metabolic processes, including fatty acid synthesis and drug metabolism. However, the role…”
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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas by Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J, Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V, Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V, Cantley, Lewis C, Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A, Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye

“…Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular…”
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The Selective A3AR Antagonist LJ-1888 Ameliorates UUO-Induced Tubulointerstitial Fibrosis by Lee, Jiyoun, Hwang, Inah, Lee, Jung H., Lee, Hyuk W., Jeong, Lak-Shin, Ha, Hunjoo

“…Adenosine in the normal kidney significantly elevates in response to cellular damage. The renal A3 adenosine receptor (A3AR) is up-regulated under stress, but…”
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Wnt/β-catenin signaling: A novel target for therapeutic intervention of fibrotic kidney disease by Hwang, Inah, Seo, Eun-young, Ha, Hunjoo

“…Fibrosis of epithelial parenchymal organs and end-stage organ failure, the final common pathway of many progressive chronic diseases including chronic kidney…”
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Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors by Hwang, Inah, Cao, Dongqing, Na, Yoonmi, Kim, Do-Yeon, Zhang, Tuo, Yao, Jun, Oh, Hwanhee, Hu, Jian, Zheng, Hongwu, Yao, Yu, Paik, Jihye

“…Loss of a cell's ability to terminally differentiate because of mutations is a selected genetic event in tumorigenesis. Genomic analyses of low-grade glioma…”
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Novel Role of Endogenous Catalase in Macrophage Polarization in Adipose Tissue by Lee, Jung Hwa, Hwang, Inah, Piao, Lingjuan, Uddin, Md. Jamal, Park, Ye Seul, Ha, Hunjoo

“…Macrophages are important components of adipose tissue inflammation, which results in metabolic diseases such as insulin resistance. Notably, obesity induces a…”
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Oxidative stress sensing and response in neural stem cell fate by Hwang, Inah, Tang, Deanna, Paik, Jihye

“…Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the adult brain and make up its regenerative potential. It is thus…”
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Integrative Omics Reveals Metabolic and Transcriptomic Alteration of Nonalcoholic Fatty Liver Disease in Catalase Knockout Mice by Na, Jinhyuk, Choi, Soo An, Khan, Adnan, Huh, Joo Young, Piao, Lingjuan, Hwang, Inah, Ha, Hunjoo, Park, Youngja H

“…The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence of obesity; however, the underlying mechanisms are unknown. In this…”
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Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy by Sohn, Minji, Kim, Keumji, Uddin, Md Jamal, Lee, Gayoung, Hwang, Inah, Kang, Hyeji, Kim, Hyunji, Lee, Jung Hwa, Ha, Hunjoo

“…Fenofibrate activates not only peroxisome proliferator-activated receptor-α (PPARα) but also adenosine monophosphate-activated protein kinase (AMPK)…”
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N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer by Berger, Adeline, Brady, Nicholas J, Bareja, Rohan, Robinson, Brian, Conteduca, Vincenza, Augello, Michael A, Puca, Loredana, Ahmed, Adnan, Dardenne, Etienne, Lu, Xiaodong, Hwang, Inah, Bagadion, Alyssa M, Sboner, Andrea, Elemento, Olivier, Paik, Jihye, Yu, Jindan, Barbieri, Christopher E, Dephoure, Noah, Beltran, Himisha, Rickman, David S

“…Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration resistant prostate cancers become…”
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ATRX loss induces telomere dysfunction and necessitates induction of alternative lengthening of telomeres during human cell immortalization by Li, Fei, Deng, Zhong, Zhang, Ling, Wu, Caizhi, Jin, Ying, Hwang, Inah, Vladimirova, Olga, Xu, Libo, Yang, Lynnie, Lu, Bin, Dheekollu, Javaraju, Li, Jian‐Yi, Feng, Hua, Hu, Jian, Vakoc, Christopher R, Ying, Haoqiang, Paik, Jihye, Lieberman, Paul M, Zheng, Hongwu

“…Loss of the histone H3.3‐specific chaperone component ATRX or its partner DAXX frequently occurs in human cancers that employ alternative lengthening of…”
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Abstract 2481: Loss of FUBP1 impairs terminal neuronal differentiation and predisposes neural progenitors for transformation by Hwang, Inah, Cao, Dongqing, Kim, Do-Yeon, Zhang, Tuo, Hu, Jian, Yao, Yu, Paik, Jihye

“…Abstract Loss of terminal differentiation capacity through genetic mutations is a selected genetic event in tumorigenesis. 1p19q co-deletion associated…”
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Therapy-Induced Transdifferentiation Promotes Glioma Growth Independent of EGFR Signaling by Oh, Hwanhee, Hwang, Inah, Jang, Ja-Young, Wu, Lingxiang, Cao, Dongqing, Yao, Jun, Ying, Haoqiang, Li, Jian Yi, Yao, Yu, Hu, Baoli, Wang, Qianghu, Zheng, Hongwu, Paik, Jihye

“…EGFR is frequently amplified, mutated, and overexpressed in malignant gliomas. Yet the EGFR-targeted therapies have thus far produced only marginal clinical…”
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FOXO1 Dependent Transcription Network Is a Targetable Vulnerability of Mantle Cell Lymphoma by Jang, Ja-Young, Hwang, Inah, Pan, Heng, Kluk, Michael, Yao, Jun, Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V, Cantley, Lewis C, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert, Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye

“…Mantle cell lymphoma (MCL) often has an adverse prognosis and despite aggressive multimodal treatment with conventional and targeted therapies, the median…”
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