Search Results - "Hwang, Daniel H."

Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid by Hwang, Daniel H., Kim, Jeong-A., Lee, Joo Young

“…Saturated fatty acids can activate Toll-like receptor 2 (TLR2) and TLR4 but polyunsaturated fatty acids, particularly docosahexaenoic acid (DHA) inhibit the…”
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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways[S] by Huang, Shurong, Rutkowsky, Jennifer M., Snodgrass, Ryan G., Ono-Moore, Kikumi D., Schneider, Dina A., Newman, John W., Adams, Sean H., Hwang, Daniel H.

“…Toll-like receptor 4 (TLR4) and TLR2 were shown to be activated by saturated fatty acids (SFAs) but inhibited by docosahexaenoic acid (DHA). However, one…”
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Acylcarnitines activate proinflammatory signaling pathways by Rutkowsky, Jennifer M, Knotts, Trina A, Ono-Moore, Kikumi D, McCoin, Colin S, Huang, Shurong, Schneider, Dina, Singh, Shamsher, Adams, Sean H, Hwang, Daniel H

“…Incomplete β-oxidation of fatty acids in mitochondria is a feature of insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that…”
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Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner by Wong, Scott W., Kwon, Myung-Ja, Choi, Augustine M.K., Kim, Hong-Pyo, Nakahira, Kiichi, Hwang, Daniel H.

“…The saturated fatty acids acylated on Lipid A of lipopolysaccharide (LPS) or bacterial lipoproteins play critical roles in ligand recognition and receptor…”
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Toll-like receptor 4-induced endoplasmic reticulum stress contributes to impairment of vasodilator action of insulin by Kim, Jeong-A, Jang, Hyun-Ju, Hwang, Daniel H

“…Impairment of vasodilator action of insulin is associated with endothelial dysfunction and insulin resistance. Activation of Toll-like receptor 4 (TLR4)…”
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Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids by Lee, Joo Y, Zhao, Ling, Hwang, Daniel H

“…Chronic inflammation is known to promote the development of many chronic diseases. Pattern recognition receptors (PRRs), Toll‐like receptors (TLRs), and…”
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Open-Source Selective Laser Sintering (OpenSLS) of Nylon and Biocompatible Polycaprolactone by Kinstlinger, Ian S, Bastian, Andreas, Paulsen, Samantha J, Hwang, Daniel H, Ta, Anderson H, Yalacki, David R, Schmidt, Tim, Miller, Jordan S

“…Selective Laser Sintering (SLS) is an additive manufacturing process that uses a laser to fuse powdered starting materials into solid 3D structures. Despite…”
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Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals by Zhao, Ling, Lee, Joo Y, Hwang, Daniel H

“…Emerging evidence reveals that pattern‐recognition receptors (PRRs), Toll‐like receptors (TLRs), and nucleotide‐binding oligomerization domain proteins (NODs)…”
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A Google Trends Approach to Identify Distinct Diurnal and Day-of-Week Web-Based Search Patterns Related to Conjunctivitis and Other Common Eye Conditions: Infodemiology Study by Deiner, Michael S, Kaur, Gurbani, McLeod, Stephen D, Schallhorn, Julie M, Chodosh, James, Hwang, Daniel H, Lietman, Thomas M, Porco, Travis C

“…Studies suggest diurnal patterns of occurrence of some eye conditions. Leveraging new information sources such as web-based search data to learn more about…”
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Inhibition of homodimerization of Toll-like receptor 4 by curcumin by Youn, Hyung S., Saitoh, Shin I., Miyake, Kensuke, Hwang, Daniel H.

“…Toll-like receptors play a key role in sensing microbial components and inducing innate immune responses. Ligand-induced dimerization of TLR4 is required for…”
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Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics by Lemay, Danielle G., Hwang, Daniel H.

“…Peroxisome proliferator-activated receptor (PPAR) agonists are currently used therapeutically in humans, even though many of their direct gene targets are…”
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Sulforaphane Suppresses Oligomerization of TLR4 in a Thiol-Dependent Manner by Youn, Hyung Sun, Kim, Yoon Sun, Park, Zee Yong, Kim, So Young, Choi, Na Young, Joung, Sun Myung, Seo, Jung A, Lim, Kyung-Min, Kwak, Mi-Kyoung, Hwang, Daniel H, Lee, Joo Young

“…TLRs are pattern recognition receptors that detect invading microorganisms and nonmicrobial endogenous molecules to trigger immune and inflammatory responses…”
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Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids by Lee, Joo Y, Plakidas, Anthony, Lee, Won H, Heikkinen, Anne, Chanmugam, Prithiva, Bray, George, Hwang, Daniel H

“…Human subjects consuming fish oil showed a significant suppression of cyclooxygenase-2 (COX-2) expression in blood monocytes when stimulated in vitro with…”
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Saturated and Polyunsaturated Fatty Acids Reciprocally Modulate Dendritic Cell Functions Mediated through TLR4 by Weatherill, A.R, Zhao, L, Lemay, D.G, Youn, H.S, Hwang, D.H

“…TLRs provide critical signals to induce innate immune responses in APCs such as dendritic cells (DCs) that in turn link to adaptive immune responses. Results…”
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Specific Inhibition of MyD88-Independent Signaling Pathways of TLR3 and TLR4 by Resveratrol: Molecular Targets Are TBK1 and RIP1 in TRIF Complex by Youn, H.S, Fitzgerald, K.A, Young, H.A, Akira, S, Hwang, D.H

“…TLRs can activate two distinct branches of downstream signaling pathways. MyD88 and Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF) pathways lead…”
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Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids by Lee, Joo Y., Ye, Jianping, Gao, Zhanguo, Youn, Hyung S., Lee, Won H., Zhao, Ling, Sizemore, Nywana, Hwang, Daniel H.

“…Toll-like receptor-4 (TLR4) can be activated by nonbacterial agonists, including saturated fatty acids. However, downstream signaling pathways activated by…”
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Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (−)-epigallocatechin-3-gallate, a polyphenol component of green tea by Youn, Hyung S., Lee, Joo Y., Saitoh, Shin I., Miyake, Kensuke, Kang, Keon W., Choi, Yong J., Hwang, Daniel H.

“…Toll-like receptors (TLRs) play an important role in recognition of microbial components and induction of innate immunity. The microbial components trigger the…”
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Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1 by Lee, Joo Y., Zhao, Ling, Youn, Hyung S., Weatherill, Amy R., Tapping, Richard, Feng, Lili, Lee, Won H., Fitzgerald, Katherine A., Hwang, Daniel H.

“…Toll-like receptor 4 (TLR4) and TLR2 agonists from bacterial origin require acylated saturated fatty acids in their molecules. Previously, we reported that…”
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Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin by Jang, Hyun-Ju, Kim, Hae-Suk, Hwang, Daniel H, Quon, Michael J, Kim, Jeong-a

“…Obesity is characterized by a chronic proinflammatory state that leads to endothelial dysfunction. Saturated fatty acids (SFA) stimulate Toll-like receptors…”
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The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors by Lee, Joo Y, Hwang, Daniel H

“…Toll-like receptors (TLRs) were evolved to detect invading pathogens and to induce innate immune responses in order to mount host defense mechanisms. It…”
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