Search Results - "Hwang, Dae Y."

Nicotine Leads to Improvements in Behavioral Impairment and an Increase in the Nicotine Acetylcholine Receptor in Transgenic Mice by Shim, Sun B., Lee, Se H., Chae, Kab R., Kim, Chuel K., Hwang, Dae Y., Kim, Byoung G., Jee, Seung W., Lee, Su H., Sin, Ji S., Bae, Chang J., Lee, Byoung C., Lee, Hyung H., Kim, Yong K.

“…Nicotine is the principal psychoactive ingredient in cigarette smoke, and has been associated with health problems in humans. However, the pure form of…”
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The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice by Cho, joon, Um, Hyun, Kang, Eun, Cho, In, Kim, Chul, Cho, Jung, Hwang, Dae

“…Exercise training was suggested as a practical therapeutic strategy for human subjects suffering from Alzheimer's disease (AD) in our previous study…”
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ERK activation induced by selenium treatment significantly downregulates β/γ-secretase activity and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M by Yim, Su, Chae, Kab, Shim, Sun, Hong, Jin, park, Jung, Lee, Chung, Son, Hong, sheen, Yhun, Hwang, Dae

“…Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation,…”
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An In Vivo Bioassay for Detecting Antiandrogens Using Humanized Transgenic Mice Coexpressing the Tetracycline-Controlled Transactivator and Human CYP1B1 Gene by Hwang, Dae Y., Cho, Jung S., Oh, Jae H., Shim, Sun B., Jee, Seung W., Lee, Su H., Seo, Su J., Kang, Hyun G., Sheen, Yhun Y., Lee, Seok H., Kim, Yong K.

“…The typical strategy used in analysis of antiandrogens involves the morphological changes of a marker in castrated rats Hershberger assay for the prostate,…”
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Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease by Hwang, Dae Y, Chae, Kab R, Kang, Tae S, Hwang, Jin H, Lim, Chae H, Kang, Hyun K, Goo, Jun S, Lee, Mi R, Lim, Hwa J, Min, Sae H, Cho, Jun Y, Hong, Jin T, Song, Chi W, Paik, Sang G, Cho, Jung S, Kim, Yong K

“…Alzheimer's disease (AD) occurs when neurons in the memory and cognition regions of the brain are accompanied by an accumulation of the long amyloid…”
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Aberrant expressions of pathogenic phenotype in Alzheimer's diseased transgenic mice carrying NSE-controlled APPsw by Hwang, Dae Y., Cho, Jung S., Lee, Su H., Chae, Kab R., Lim, Hwa J., Min, Sea H., Seo, Su J., Song, Youn S., Song, Chi W., Paik, Sang G., Sheen, Yhun Y., Kim, Yong K.

“…Mutations in the APP gene lead to enhanced cleavage by the β- and γ-secretase, and increased Aβ formation, which are tightly associated with Alzheimer's…”
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Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease by Hwang, Dae Y, Cho, Jung S, Oh, Jae H, Shim, Sun B, Jee, Seung W, Lee, Su H, Seo, Su J, Lee, Sang-Koo, Lee, Seok H, Kim, Yong K

“…Mutations in genes for Alzheimer's disease (AD) result in a modulating of gene expressions in the brains of patients with AD. The aim of this study was to…”
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Signaling through 3′,5′-Cyclic Adenosine Monophosphate and Phosphoinositide-3 Kinase Induces Sodium/Iodide Symporter Expression in Breast Cancer by Knostman, Katherine A. B., Cho, Je-Yoel, Ryu, Kwon-Yul, Lin, Xiaoqin, McCubrey, James A., Hla, Timothy, Liu, Catherine H., Di Carlo, Emma, Keri, Ruth, Zhang, Ming, Hwang, Dae Y., Kisseberth, William C., Capen, Charles C., Jhiang, Sissy M.

“…The sodium/iodide symporter (NIS) is a membrane transport glycoprotein normally expressed in the thyroid gland and lactating mammary gland. NIS is a target for…”
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Oligonucleotide-based analysis of differentially expressed genes in hippocampus of transgenic mice expressing NSE-controlled APPsw by Jee, Seung W, Cho, Jung S, Kim, Chuel K, Hwang, Dae Y, Shim, Sun B, Lee, Su H, Sin, Ji S, Park, Jin H, Kim, Yang S, Choi, Soo Y, Kim, Yong K

“…The complexity of Alzheimer's disease (AD) has made it difficult to examine its underlying mechanisms. A gene microarray offers a solution to the complexity…”
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PEN-2 overexpression induces gamma-secretase protein and its activity with amyloid beta-42 production by Seo, Su J, Hwang, Dae Y, Cho, Jung S, Chae, Kab R, Kim, Chuel K, Shim, Sun B, Jee, Seung W, Lee, Su H, Sin, Ji S, Choi, Soo Y, Kim, Joon, Kim, Yong K

“…PEN-2 is a component of the gamma-secretase complex, which is involved in the cleavage of the beta-amyloid precursor protein. The aim of this study was to…”
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Tau and GSK3β Dephosphorylations are Required for Regulating Pin1 Phosphorylation by Min, Sae H., Cho, Jung S., Oh, Jae H., Shim, Sun B., Hwang, Dae Y., Lee, Su H., Jee, Seung W., Lim, Hwa J., Kim, Min Y., Sheen, Yhun Y., Lee, Seok H., Kim, Yong K.

“…Pin1 binds mitotically phosphorylated Thr231-Pro232 and Thr212-Pro213 sites on tau, and a Pin1 deficiency in mice leads to tau hyperphosphorylation. The aim of…”
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Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease by Cho, Jun Y, Hwang, Dae Y, Kang, Tae S, Shin, Dong H, Hwang, Jin H, Lim, Chae H, Lee, Su H, Lim, Hwa J, Min, Sae H, Seo, Su J, Song, Youn S, Nam, Ki T, Lee, Kyu S, Cho, Jung S, Kim, Yong K

“…In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice…”
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Analysis of differentially expressed genes in early- and late-stage APPsw-transgenic and normal mice using cDNA microarray by Jee, Seung, Cho, Jung, Kim, Chuel, Hwang, Dae, Shim, Sun, Lee, Su, Sin, Ji, Kim, Yang, Park, Jin, Lee, Se, Choi, Soo, Kim, Yong

“…The complexity of Alzheimer's disease (AD) has made it difficult to examine its underlying mechanism. A gene microarray offers a solution to the complexity…”
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Aging-related correlation of insulin-degrading enzyme with gamma-secretase-generated products involving insulin and glucose levels in transgenic mice by Hwang, Dae Y, Cho, Jung S, Kim, Chuel K, Shim, Sun B, Jee, Seung W, Lee, Su H, Seo, Su J, Cho, Joon Y, Lee, Seok H, Kim, Yong K

“…Insulin-degrading enzyme (IDE) is a 110-kDa thiol zinc-methalloendopeptidase that can cleave small Abeta peptides and the APP intracellular domain (AICD). The…”
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NSE-Controlled Carboxyl-Terminus of APP Gene Over-Expressing in Transgenic Mice Induces Altered Expressions in Behavior, Aβ-42, and GSK3β Binding Proteins by Lim, Hwa J., Cho, Jung S., Oh, Jae H., Shim, Sun B., Hwang, Dae Y., Jee, Seung W., Lee, Su H., Sheen, Yhun Y., Lee, Seok H., Kim, Yong K.

“…The amyloid protein precursor (APP) is cleaved in its intramembranous domain by gamma -secrease to generate amyloid beta and a free carboxyl-terminal…”
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Changes in presenilin 2-binding Wnt proteins, behavior, amyloid-beta 42, gamma-secretase activity, and testosterone sensitivity in transgenic mice coexpressing tetracycline-controlled transactivator and human mutant presenilin 2 by Hwang, Dae Y, Cho, Jung S, Kim, Chuel K, Shim, Sun B, Jee, Seung W, Lee, Su H, Seo, Su J, Choi, Soo Y, Kim, Yong K

“…Nonregulatable promoters have been mainly used to produce transgenic mice that express the human genes for Alzheimer's disease (AD). The aim of this study was…”
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Early changes in behavior deficits, amyloid beta-42 deposits and MAPK activation in doubly transgenic mice co-expressing NSE-controlled human mutant PS2 and APPsw by Hwang, Dae Y, Cho, Jung S, Oh, Jae H, Shim, Sun B, Jee, Seung W, Lee, Su H, Seo, Su J, Song, Chi W, Lee, Seok H, Kim, Yong K

“…1. Doubly transgenic mice were some differences in the period proceeding of the development of Abeta-42 deposits and behavioral deficits. It was not…”
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cDNA microarray-based analysis of differentially expressed genes in transgenic brains expressing NSE-controlled APPsw by Jee, Seung W, Cho, Jung S, Oh, Jae H, Shim, Sun B, Hwang, Dae Y, Lee, Su H, Song, Youn S, Lee, Seok H, Kim, Yong K

“…cDNA microarray technique has been widely used for the detection and elucidation of differentially expressed genes on a large scale and at a speed never before…”
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Differential Effect of 7,12-Dimethylbenz[a]anthracene on Human and Mouse CYP1B1 from Livers of Castrated Transgenic Mice by Hwang, Dae Y., Chae, Kab R., Kim, Chuel K., Kim, Byoung G., Shim, Sun B., Jee, Seung W., Lee, Su H., Sin, Ji S., Jang, Mee K., Seo, Su J., Kim, Min S., Cho, Jung S., Sheen, Yhun Y., Choi, Soo Y., Kim, Yong K.

“…Humanized transgenic mice coexpressing tetracycline-controlled transactivator (tTA) and human cytochrome P450 1B1 (CYP1B1) (hCYP1B1) have been created by this…”
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Differential expression of the tetracycline-controlled transactivator-driven human CYP1B1 gene in double-transgenic mice is due to androgens: application for detecting androgens and antiandrogens by Hwang, Dae Y, Cho, Jung S, Chae, Kab R, Kang, Tae S, Hwang, Jin H, Lim, Chae H, Lee, Su H, Lim, Hwa J, Min, Sae H, Sheen, Yhun Y, Jang, In S, Kim, Yong K

“…Differential expression of the tetracycline-controlled transactivator (tTA)-driven human cytochrome P450 (CYP) 1B1 gene was found in the livers of male mice,…”
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