Search Results - "Hvass, Lars"
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Development of 18F-Labeled Bispyridyl Tetrazines for In Vivo Pretargeted PET Imaging
Published in Pharmaceuticals (Basel, Switzerland) (18-02-2022)“…Pretargeted PET imaging is an emerging and fast-developing method to monitor immuno-oncology strategies. Currently, tetrazine ligation is considered the most…”
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Lipophilicity and Click Reactivity Determine the Performance of Bioorthogonal Tetrazine Tools in Pretargeted In Vivo Chemistry
Published in ACS pharmacology & translational science (09-04-2021)“…The development of highly selective and fast biocompatible reactions for ligation and cleavage has paved the way for new diagnostic and therapeutic…”
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3
Development of Polar BODIPY-Tetrazines for Rapid Pretargeted Fluorescence Imaging
Published in ACS omega (15-10-2024)“…Polar BODIPY-tetrazine dyes were developed and clicked in vivo to a preaccumulated trans-cyclooctene-modified anti-TAG72 monoclonal antibody CC49 (CC49-TCO)…”
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4
[ 68 Ga]Ga-DOTAGA-Glu(FAPi) 2 Shows Enhanced Tumor Uptake and Theranostic Potential in Preclinical PET Imaging
Published in Diagnostics (Basel) (13-09-2024)“…The use of fibroblast activation protein inhibitors (FAPis) for positron emission tomography (PET) imaging in cancer has garnered significant interest in…”
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Development of BODIPY-Tetrazines as Pretargeted Bimodal Fluorescent-Radioactive Tracers
Published in Nuclear medicine and biology (01-11-2023)Get full text
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Development of five Polar and Highly Reactive Tetrazines for Pretargeted Imaging
Published in Nuclear medicine and biology (01-11-2023)Get full text
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7
Abstract 6034: PSMA targeted alpha radiopharmaceutical [211At]PSAt-3 inhibits tumor growth in a preclinical model of prostate cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Introduction: Prostate cancer continues to be a highly prevalent cancer diagnosis among men and a leading cause of cancer related deaths worldwide…”
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Development of 11C-Tucatinib as a potential HER2-targeting PET radiotracer
Published in Nuclear medicine and biology (01-05-2022)Get full text
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P-287 - Development of 11C-Tucatinib as a potential HER2-targeting PET radiotracer
Published in Nuclear medicine and biology (01-05-2022)Get full text
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10
Extracorporeal clearing traps based on tetrazine ligation for pretargeted therapy and diagnostics
Published in Nuclear medicine and biology (01-05-2022)Get full text
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P-299 - Extracorporeal clearing traps based on tetrazine ligation for pretargeted therapy and diagnostics
Published in Nuclear medicine and biology (01-05-2022)Get full text
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12
Development of the First Aliphatic 18F‑Labeled Tetrazine Suitable for Pretargeted PET ImagingExpanding the Bioorthogonal Tool Box
Published in Journal of medicinal chemistry (28-10-2021)“…Pretargeted imaging of nanomedicines have attracted considerable interest because it has the potential to increase imaging contrast while reducing radiation…”
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Development of aliphatic 18F-labeled tetrazines suitable for pretargeted PET imaging
Published in Nuclear medicine and biology (01-05-2022)Get full text
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14
P-237 - Development of aliphatic 18F-labeled tetrazines suitable for pretargeted PET imaging
Published in Nuclear medicine and biology (01-05-2022)Get full text
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15
Development of the First Aliphatic 18 F-Labeled Tetrazine Suitable for Pretargeted PET Imaging-Expanding the Bioorthogonal Tool Box
Published in Journal of medicinal chemistry (28-10-2021)“…Pretargeted imaging of nanomedicines have attracted considerable interest because it has the potential to increase imaging contrast while reducing radiation…”
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16
Development and Preclinical Evaluation of [211At]PSAt-3-Ga: An Inhibitor for Targeted a-Therapy of Prostate Cancer
Published in The Journal of nuclear medicine (1978) (01-04-2024)“…The application of prostate -specific membrane antigen (PSMA)- targeted a -therapy is a promising alternative to b 2 -particle-based treatments. 211 At is…”
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Synthesis and in vivo evaluation of [11C]tucatinib for HER2-targeted PET imaging
Published in Bioorganic & medicinal chemistry letters (15-01-2023)“…[Display omitted] •[11C]tucatinib was designed and synthesized as a HER2 PET imaging agent•The compound was obtained in a 12 steps synthetic…”
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Development and Preclinical Evaluation of [ 211 At]PSAt-3-Ga: An Inhibitor for Targeted α-Therapy of Prostate Cancer
Published in Journal of Nuclear Medicine (01-04-2024)“…The application of prostate-specific membrane antigen (PSMA)-targeted α-therapy is a promising alternative to β -particle-based treatments. At is among the…”
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19
Bioorthogonal Click of Colloidal Gold Nanoparticles to Antibodies In vivo
Published in Chemistry : a European journal (02-11-2022)“…Combining nanotechnology and bioorthogonal chemistry for theranostic strategies offers the possibility to develop next generation nanomedicines. These…”
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Optimized QMA-elution enables direct aliphatic 18F-fluorination of highly reactive tetrazines for pretargeted imaging
Published in Nuclear medicine and biology (01-05-2022)Get full text
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