Search Results - "Huynh, Tony"
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APR-246 induces early cell death by ferroptosis in acute myeloid leukemia
Published in Haematologica (Roma) (01-02-2022)“…APR-246 is a promising new therapeutic agent that targets p53 mutated proteins in myelodysplastic syndromes and in acute myeloid leukemia (AML). APR-246…”
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2
Early Oligocene kelp holdfasts and stepwise evolution of the kelp ecosystem in the North Pacific
Published in Proceedings of the National Academy of Sciences - PNAS (23-01-2024)“…Kelp forests are highly productive and economically important ecosystems worldwide, especially in the North Pacific Ocean. However, current hypotheses for…”
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3
Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy
Published in Cancer research (Chicago, Ill.) (01-07-2019)“…Compelling evidence points to immune cell infiltration as a critical component of successful immunotherapy. However, there are currently no clinically…”
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Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18 F-FAraG PET and MRI
Published in Journal of Nuclear Medicine (01-01-2022)“…Lymphocytes and innate immune cells are key drivers of multiple sclerosis (MS) and are the main target of MS disease-modifying therapies (DMT). Ex vivo…”
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5
Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI
Published in The Journal of nuclear medicine (1978) (01-01-2022)“…Lymphocytes and innate immune cells are key drivers of multiple sclerosis (MS) and are the main target of MS disease-modifying therapies (DMT). Ex vivo…”
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6
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism
Published in Cell reports (Cambridge) (21-09-2021)“…Cold-induced thermogenesis in endotherms demands adaptive thermogenesis fueled by mitochondrial respiration and Ucp1-mediated uncoupling in multilocular brown…”
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Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar‐potency inhibitor of calcium‐activated chloride channel TMEM16A
Published in The FASEB journal (01-10-2019)“…ABSTRACT Interstitial cells of Cajal, which express the calcium‐activated chloride channel transmembrane member 16A (TMEM16A), are an important determinant of…”
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[ 11 C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat
Published in The Journal of pharmacology and experimental therapeutics (01-02-2024)“…Synthesis of the acetylcholinesterase inhibitor paraoxon (POX) as a carbon-11 positron emission tomography tracer ([ C]POX) and profiling in live rats is…”
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18 F-AraG PET for CD8 Profiling of Tumors and Assessment of Immunomodulation by Chemotherapy
Published in Journal of Nuclear Medicine (01-06-2021)“…Most clinical trials exploring various combinations of chemo- and immunotherapy rely on serial biopsy to provide information on immune response. The aim of…”
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18F-AraG PET for CD8 Profiling of Tumors and Assessment of Immunomodulation by Chemotherapy
Published in The Journal of nuclear medicine (1978) (01-06-2021)“…Most clinical trials exploring various combinations of chemo- and immunotherapy rely on serial biopsy to provide information on immune response. The aim of…”
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Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET
Published in Clinical cancer research (01-03-2021)“…We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, […”
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12
Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin
Published in Proceedings of the National Academy of Sciences - PNAS (04-05-2021)“…The role of integrins, in particular αv integrins, in regulating insulin resistance is incompletely understood. We have previously shown that the αvβ5 integrin…”
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Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy
Published in Molecular pharmaceutics (03-09-2019)“…Boron neutron capture therapy (BNCT) is a therapeutic modality which has been used for the treatment of cancers, including brain and head and neck tumors. For…”
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Genetic variation in Austrostrongylus thylogale Johnston & Mawson, 1940 (Nematoda: Trichostrongylida) from the tammar wallaby, Notamacropus eugenii (Gray), and the quokka, Setonix brachyurus (Quoy & Gaimard) (Marsupialia: Macropodidae) in Australia
Published in Parasites & vectors (14-03-2020)“…Australian marsupials harbour a diverse array of helminth parasites. Despite current attempts to assess the extent of this diversity in macropodid hosts, it…”
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Exposure toxicity of venetoclax in acute myeloid leukemia patients in the real-life setting: impact of high exposure on delayed neutropenia
Published in Haematologica (Roma) (17-10-2024)“…Not available.Not available…”
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Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis
Published in Nature communications (29-05-2024)“…Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous…”
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A Feasibility Study of [18F]F-AraG Positron Emission Tomography (PET) for Cardiac Imaging–Myocardial Viability in Ischemia–Reperfusion Injury Model
Published in Molecular imaging and biology (01-10-2024)“…Purpose Myocardial infarction (MI) with subsequent inflammation is one of the most common heart conditions leading to progressive tissue damage. A reliable…”
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18
Flip Distances Between Graph Orientations
Published in Algorithmica (01-01-2021)“…Flip graphs are a ubiquitous class of graphs, which encode relations on a set of combinatorial objects by elementary, local changes. Skeletons of associahedra,…”
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Evaluating Radioactive Analogs of Doxorubicin to Quantify ChemoFilter Binding and Whole-Body Positron Emission Tomography/Magnetic Resonance Imaging for Drug Biodistribution
Published in Journal of vascular and interventional radiology (01-06-2022)“…To evaluate radiolabeled doxorubicin (Dox) analogs as tracers of baseline Dox biodistribution in vivo during hepatic intra-arterial chemotherapy and to assess…”
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Mapping care provision for type 1 diabetes throughout Australia: a protocol for a mixed-method study
Published in BMJ open (16-12-2022)“…IntroductionType 1 diabetes (T1D) is a chronic and incurable autoimmune disease, diagnosed in early childhood and managed initially in paediatric healthcare…”
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