Social behavior deficits in the Fmr1 mutant mouse

Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social intera...

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Bibliographic Details
Published in:	Behavioural brain research Vol. 168; no. 1; pp. 172 - 175
Main Authors:	Mineur, Yann S., Huynh, Linh X., Crusio, Wim E.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier B.V 15-03-2006 Elsevier Science
Subjects:	Animals Autism Autistic Disorder - psychology BALB/cJ Biological and medical sciences C57BL/6J Child clinical studies DBA/2J Developmental disorders Female Fmr1 KO Fragile X Mental Retardation Protein - genetics Fragile X Syndrome Habituation, Psychophysiologic - physiology Infantile autism Interpersonal Relations Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mouse model of autism Mutation - genetics Mutation - physiology Ovariectomy Pilot Projects Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Social Behavior Social Environment Species Specificity Autism BALB/cJ Social behavior Fragile X Syndrome Mouse model of autism C57BL/6J DBA/2J Fmr1 KO Chromosome fragility Animal model Rodentia Developmental disorder Mus domesticus Strain Vertebrata Mammalia Social interaction Mutation Fragile X syndrome Comparative study
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Summary:	Mice exhibiting deficits in social behavior may provide valuable models for autistic-like behavioral problems. We tested social interactions in male mice from three inbred strains: C57BL/6J (B6), BALB/cJ (C) and DBA/2J (D2). All three strains showed gradual habituation of the number of social interactions with an ovariectomized female over four subsequent 2 min sessions, returning to initial levels when presented with another stimulus mouse. Next, we studied males with a knockout mutation in the Fmr1 gene on a B6 background. KO animals showed strongly reduced levels of social interaction, which were about similar as those of habituated controls. This social behavior deficit suggests that Fmr1 KO mice could possibly be used as models for autistic behaviors.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0166-4328 1872-7549
DOI:	10.1016/j.bbr.2005.11.004