Search Results - "Huwaimel, Bader"

Anti-Cancer Drug Solubility Development within a Green Solvent: Design of Novel and Robust Mathematical Models Based on Artificial Intelligence by Huwaimel, Bader, Alobaida, Ahmed

“…Nowadays, supercritical CO2(SC-CO2) is known as a promising alternative for challengeable organic solvents in the pharmaceutical industry. The mathematical…”
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Access to Highly Strained Tricyclic Ketals Derived from Coumarins by Jonnalagadda, Sravan K, Huwaimel, Bader I, Jonnalagadda, Shirisha, Garrison, Jered C, Trippier, Paul C

“…Synthesis of highly strained fused substituted dihydrobenzopyran cyclopropyl lactones derived from coumarin carboxylates are reported. The substrate scope…”
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Chlorinated benzothiadiazines inhibit angiogenesis through suppression of VEGFR2 phosphorylation by Huwaimel, Bader I., Jonnalagadda, Sravan, Jonnalagadda, Shirisha, Zahra, Fatema T., Nocentini, Alessio, Supuran, Claudiu T., Mikelis, Constantinos M., Trippier, Paul C.

“…[Display omitted] Angiogenesis inhibitors are a critical pharmacological tool for the treatment of solid tumors. Suppressing vascular permeability leads to…”
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Development of computational intelligence models for assessment of drug nanonization using green chemistry technique: Improvement of drug solubility by Huwaimel, Bader, Alharby, Tareq Nafea

“…Determination of solubility via theoretical approaches was carried out in this study. Because of its importance to the expansion of the pharmaceutical…”
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Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds by Gomha, Sobhi, Riyadh, Sayed, Huwaimel, Bader, Zayed, Mohie, Abdellattif, Magda

“…Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for…”
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A novel combination of machine learning models and metaheuristic algorithm to predict important parameters of twin screw wet granulation process by Alharby, Tareq Nafea, Alanazi, Jowaher, Alanazi, Muteb, Huwaimel, Bader

“…Twin screw granulation (TSG) has recently been emerged as a novel approach for the continuous wet granulation of fine particles (i.e., powders) in the…”
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Structural and free energy landscape analysis for the discovery of antiviral compounds targeting the cap-binding domain of influenza polymerase PB2 by Abouzied, Amr S., Alqarni, Saad, Younes, Kareem M., Alanazi, Sanad M., Alrsheed, Dana M., Alhathal, Rawabi K., Huwaimel, Bader, Elkashlan, Akram M.

“…Influenza poses a significant threat to global health, with the ability to cause severe epidemics and pandemics. The polymerase basic protein 2 (PB2) of the…”
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Enhanced photocatalytic efficiency and biosensing in plasmonic nanostructures for the detection of bacteria in various analytes by Qureshi, Muhammad Tauseef, Tehseen, Aqsa, Iqbal, Tahir, Afsheen, Sumera, Ahsan, Sayyam, Maryam, Iqra, Huwaimel, Bader, Hameed, Reda Abdel, Farghaly, Othman, Atta, Ayman

“…The interaction of transverse magnetic (TM) plane waves with 1D metallic bowtie gratings on glass substrate has been used for surface plasmon polaritons (SPPs)…”
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Development of a novel machine learning approach to optimize important parameters for improving the solubility of an anti-cancer drug within green chemistry solvent by Alanazi, Muteb, Huwaimel, Bader, Alanazi, Jowaher, Alharby, Tareq Nafea

“…Understanding the solubility of drug particles in solvents has remained a big challenge in different fields. Development of advanced computational methods to…”
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Green synthesis of zinc sulfide nanoparticles-organic heterocyclic polyol system as eco-friendly anti corrosion and anti-bacterial corrosion inhibitor for steel in acidic environment by Abdel Hameed, Reda, Faride, Mohamad, Othman, Mohamad, Huwaimel, Bader, Al-Mhyawi, Saedah, Shamroukh, Ahmed, Alshammary, Freah, Aljuhani, Enas, Abdallah, Metwally

“…Green synthesis, characterization and evaluation of nanoscale zinc sulfide (ZnS) by precipitation chemical method. The zinc sulfide nanoparticles were prepared…”
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Delafloxacin-Capped Gold Nanoparticles (DFX-AuNPs): An Effective Antibacterial Nano-Formulation of Fluoroquinolone Antibiotic by Abu Lila, Amr Selim, Huwaimel, Bader, Alobaida, Ahmed, Hussain, Talib, Rafi, Zeeshan, Mehmood, Khalid, Abdallah, Marwa H, Hagbani, Turki Al, Rizvi, Syed Mohd Danish, Moin, Afrasim, Ahmed, Abobakr F

“…New antibiotics are seen as ‘drugs of last resort’ against virulent bacteria. However, development of resistance towards new antibiotics with time is a…”
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Manganese chloride (MnCl2) induced novel model of Parkinson’s disease in adult Zebrafish; Involvement of oxidative stress, neuroinflammation and apoptosis pathway by Nadig, Abhishek.P.R., Huwaimel, Bader, Alobaida, Ahmed, Khafagy, El-Sayed, Alotaibi, Hadil Faris, Moin, Afrasim, Lila, Amr Selim Abu, Suman, M, Sahyadri, Krishna, K.L.

“…Parkinson’s disease (PD) is a progressive neurodegenerative disorder imposing a severe health and socioeconomic burden worldwide. Existing pharmacological…”
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Development a novel robust method to enhance the solubility of Oxaprozin as nonsteroidal anti-inflammatory drug based on machine-learning by Abdelbasset, Walid Kamal, Elkholi, Safaa M., Ismail, Khadiga Ahmed, Alshehri, Sameer, Alobaida, Ahmed, Huwaimel, Bader, Alatawi, Ahmed D., Alsubaiyel, Amal M., Venkatesan, Kumar, Abourehab, Mohammed A. S.

“…Accurate specification of the drugs’ solubility is known as an important activity to appropriately manage the supercritical impregnation process. Over the last…”
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Phytochemical composition, in vitro cytotoxicity, and in silico docking properties of Tamarix tetragyna L by Huwaimel, Bader, Younes, Kareem M., Abouzied, Amr S., Elkashlan, Akram M., Alheibshy, Fawaz N., Alobaida, Ahmed, Turki, Abdullah, Alquwaiay, Saleh A., Alqahatani, Naif, Alsuwayagh, Sulaiman A.

“…Tamarix tetragyna is a plant grows in Mediterranean area and some Arab countries. It possesses numerous medicinal values. Purpose of our study is to explore…”
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Selective carbonic anhydrase IX and XII inhibitors based around a functionalized coumarin scaffold by Huwaimel, Bader I., Jonnalagadda, Sravan K., Jonnalagadda, Shirisha, Kumari, Shikha, Nocentini, Alessio, Supuran, Claudiu T., Trippier, Paul C.

“…Inhibition of specific carbonic anhydrase (CA) enzymes is a validated strategy for the development of agents to target cancer. The CA isoforms IX and XII are…”
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Design, Synthesis, Characterization and Computational Studies of Mannich Bases Oxadiazole Derivatives as New Class of Jack Bean Urease Inhibitors by Mutahir, Sadaf, Khan, Muhammad Asim, Almehizia, Abdulrahman Abdulaziz, Abouzied, Amr Salah, Khalifa, Nasrin Eldirdiri, Naglah, Ahmed Mohamed, Deng, Haishan, Refat, Moamen Salaheldeen, Khojali, Weam Mohamed Ali, Huwaimel, Bader

“…Mannich bases consisting of 1,3,4‐oxadiazole‐2‐thione (3 a–3 l) bearing various substituents were synthesized and found potent jack bean urease inhibitors. The…”
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DFT study of carboplatin encapsulation interactions with carboxylated carbon nanotubes and conjugated to folic acid for targeted nano delivery systems by Hani, Umme, Huwaimel, Bader, Alsubaiyel, Amal M., Alshahrani, Saad M., Alshammari, Farhan, Alanazi, Jowaher, Alanazi, Muteb, Alharby, Tareq Nafea

“…In this study, a nano-drug delivery design based on (8, 8) carboxylated single-walled carbon nanotube (CNT-COOH) and folic acid (FA) decorated on CNT-COOH…”
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Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity by Huwaimel, Bader I., Bhakta, Myla, Kulkarni, Chaitanya A., Milliken, Alexander S., Wang, Feifei, Peng, Aimin, Brookes, Paul S., Trippier, Paul C.

“…Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase, plays a critical role in mitochondrial metabolism. Known but low potency CII…”
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Synthesis, Crystal Structure, Antibacterial and In Vitro Anticancer Activity of Novel Macroacyclic Schiff Bases and Their Cu (II) Complexes Derived from S -Methyl and S -Benzyl Dithiocarbazate by Break, Mohammed Khaled Bin, Fung, Tan Yew, Koh, May Zie, Ho, Wan Yong, Tahir, Mohamed Ibrahim Mohamed, Elfar, Omar Ashraf, Syed, Rahamat Unissa, Khojali, Weam M A, Alluhaibi, Turki Mubarak, Huwaimel, Bader, Wiart, Christophe, Khoo, Teng-Jin

“…A series of novel macroacyclic Schiff base ligands and their Cu (II) complexes were synthesised via reacting dicarbonyls of varying chain lengths with -methyl…”
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Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug by Abdelbasset, Walid Kamal, Elsayed, Shereen H, Alshehri, Sameer, Huwaimel, Bader, Alobaida, Ahmed, Alsubaiyel, Amal M, Alqahtani, Abdulsalam A, El Hamd, Mohamed A, Venkatesan, Kumar, AboRas, Kareem M, Abourehab, Mohammed A. S

“…The efficient production of solid-dosage oral formulations using eco-friendly supercritical solvents is known as a breakthrough technology towards developing…”
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