Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test

Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1). The aims of this study were to evaluate the before and after treatment outcome with corticosteroid,...

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Bibliographic Details
Published in:	Open access Macedonian journal of medical sciences Vol. 7; no. 2; pp. 195 - 197
Main Authors:	Van, Anh Tran Thi, Nguyen, Thuong Van, Huu, Sau Nguyen, Thi, Lan Pham, Minh, Phuong Pham Thi, Huu, NghiDinh, Cam, Van Tran, Huyen, My Le, Nguyet, Minh Vu, Hau, Khang Tran, Gandolfi, Marco, Satolli, Francesca, Feliciani, Claudio, Tirant, Michael, Vojvodic, Aleksandra, Lotti, Torello
Format:	Journal Article
Language:	English
Published:	Macedonia Republic of Macedonia 30-01-2019
Subjects:	Clinical Science Desmoglein Pemphigus ELISA
Online Access:	Get full text
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Summary:	Pemphigus Vulgaris (PV) is a chronic disease, is characterized by the presence of flacid bullous in skin and mucosa. There are 2 main autoantibodies against desmoglein3 (Dsg3) and desmoglein1 (Dsg1). The aims of this study were to evaluate the before and after treatment outcome with corticosteroid, using Desmoglein ELISA test. Forty patients with Pemphigus include 36 PV and 4 PF (28 women, 12 women) were enrolled. The titers of Dsg in pemphigus patients by using ELISA test were done before and 1-month treatment. Both anti-Dsg1 and anti-Dsg3 levels were significantly reduced after treatment (P < 0.05). The severity of skin lesions was correlated with anti-Dsg1 antibody level and the severity of oral lesions was significantly correlated with anti-Dsg 3 antibody levels (p < 0.05). It is recommended that we can predict and improve the outcome of treatment by using Desmoglein ELISA test.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1857-9655 1857-9655
DOI:	10.3889/oamjms.2019.003