Search Results - "Hutz, Mara"

The dopamine transporter role in psychiatric phenotypes by Salatino‐Oliveira, Angélica, Rohde, Luis A., Hutz, Mara H.

“…The dopamine transporter (DAT) is one of the most relevant and investigated neurotransmitter transporters. DAT is a plasma membrane protein which plays a…”
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Distribution of CYP2D6 alleles and phenotypes in the Brazilian population by Friedrich, Deise C, Genro, Júlia P, Sortica, Vinicius A, Suarez-Kurtz, Guilherme, de Moraes, Maria Elizabete, Pena, Sergio D J, dos Santos, Andrea K Ribeiro, Romano-Silva, Marco A, Hutz, Mara H

“…The CYP2D6 enzyme is one of the most important members of the cytochrome P450 superfamily. This enzyme metabolizes approximately 25% of currently prescribed…”
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The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected by Pena, Sérgio D J, Di Pietro, Giuliano, Fuchshuber-Moraes, Mateus, Genro, Julia Pasqualini, Hutz, Mara H, Kehdy, Fernanda de Souza Gomes, Kohlrausch, Fabiana, Magno, Luiz Alexandre Viana, Montenegro, Raquel Carvalho, Moraes, Manoel Odorico, de Moraes, Maria Elisabete Amaral, de Moraes, Milene Raiol, Ojopi, Elida B, Perini, Jamila A, Racciopi, Clarice, Ribeiro-Dos-Santos, Andrea Kely Campos, Rios-Santos, Fabrício, Romano-Silva, Marco A, Sortica, Vinicius A, Suarez-Kurtz, Guilherme

“…Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as…”
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Assessing individual interethnic admixture and population substructure using a 48-insertion-deletion (INSEL) ancestry-informative marker (AIM) panel by Santos, Ney P.C, Ribeiro-Rodrigues, Elzemar M, Ribeiro-dos-Santos, Ândrea K.C, Pereira, Rui, Gusmão, Leonor, Amorim, António, Guerreiro, Joáo F, Zago, Marco A, Matte, Cecília, Hutz, Mara H, Santos, Sidney E.B

“…Estimating the proportions of different ancestries in admixed populations is very important in population genetics studies, and it is particularly important…”
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Global pharmacogenomics: distribution of CYP3A5 polymorphisms and phenotypes in the Brazilian population by Suarez-Kurtz, Guilherme, Vargens, Daniela D, Santoro, Ana Beatriz, Hutz, Mara H, de Moraes, Maria Elisabete, Pena, Sérgio D J, Ribeiro-dos-Santos, Ândrea, Romano-Silva, Marco A, Struchiner, Claudio José

“…The influence of self-reported "race/color", geographical origin and genetic ancestry on the distribution of three functional CYP3A5 polymorphisms, their…”
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Tumor necrosis factor alpha polymorphisms are associated with Parkinson’s disease age at onset by Lindenau, Juliana D., Altmann, Vivian, Schumacher-Schuh, Artur F., Rieder, Carlos R., Hutz, Mara H.

“…•The role of neuroinflammation in Parkinson’s disease has already been demonstrated.•TNF-α Polymorphisms are associated with different inflammatory…”
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NUDT15 Polymorphism in Native American Populations of Brazil by Suarez‐Kurtz, Guilherme, Brisson, Gisele D., Hutz, Mara H., Petzl‐Erler, Maria Luiza, Salzano, Francisco M.

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Stress-related genetic components in attention-deficit/hyperactivity disorder (ADHD): Effects of the SERPINA6 and SERPINA1 genetic markers in a family-based brazilian sample by Carpena, Marina Xavier, Sánchez-Luquez, Karen Yumaira, Martins-Silva, Thais, Santos, Thiago M, Farias, Cid Pinheiro, Leventhal, Daniel Gray Paschoal, Berruti, Barbara, Zeni, Cristian Patrick, Schmitz, Marcelo, Chazan, Rodrigo, Hutz, Mara H., Salatino-Oliveira, Angélica, Genro, Julia P., Rohde, Luis Augusto, Tovo-Rodrigues, Luciana

“…SERPINA6 and SERPINA1 were recently identified as the main genes associated with plasma cortisol concentration in humans. Although dysregulation in the…”
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Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region by de Brito Vargas, Luciana, Beltrame, Marcia H, Ho, Brenda, Marin, Wesley M, Dandekar, Ravi, Montero-Martín, Gonzalo, Fernández-Viña, Marcelo A, Hurtado, A Magdalena, Hill, Kim R, Tsuneto, Luiza T, Hutz, Mara H, Salzano, Francisco M, Petzl-Erler, Maria Luiza, Hollenbach, Jill A, Augusto, Danillo G

“…Abstract The killer-cell immunoglobulin-like receptors (KIR) recognize human leukocyte antigen (HLA) molecules to regulate the cytotoxic and inflammatory…”
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DRD4 rare variants in Attention-Deficit/Hyperactivity Disorder (ADHD): further evidence from a birth cohort study by Tovo-Rodrigues, Luciana, Rohde, Luis A, Menezes, Ana M B, Polanczyk, Guilherme V, Kieling, Christian, Genro, Julia P, Anselmi, Luciana, Hutz, Mara H

“…The dopamine receptor D4 (DRD4) is one of the most studied candidate genes for Attention-Deficit/Hyperactivity Disorder (ADHD). An excess of rare variants and…”
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Association of genetic variants with self-assessed color categories in Brazilians by Durso, Danielle Fernandes, Bydlowski, Sergio Paulo, Hutz, Mara Helena, Suarez-Kurtz, Guilherme, Magalhães, Tiago R, Pena, Sérgio Danilo Junho

“…The Brazilian population was formed by extensive admixture of three different ancestral roots: Amerindians, Europeans and Africans. Our previous work has shown…”
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Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairment by Altmann, Vivian, Schumacher-Schuh, Artur F., Rieck, Mariana, Callegari-Jacques, Sidia M., Rieder, Carlos R.M., Hutz, Mara H.

“…•The role of BDNF VAL66Met in Parkinson's disease cognitive impairment was explored in this study.•BDNF 66Met allele presented a higher prevalence of cognitive…”
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CLOCK Polymorphisms in Attention-Deficit/Hyperactivity Disorder (ADHD): Further Evidence Linking Sleep and Circadian Disturbances and ADHD by Carpena, Marina Xavier, Hutz, Mara H, Salatino-Oliveira, Angélica, Polanczyk, Guilherme V, Zeni, Cristian, Schmitz, Marcelo, Chazan, Rodrigo, Genro, Julia P, Rohde, Luis Augusto, Tovo-Rodrigues, Luciana

“…Circadian and sleep disorders, short sleep duration, and evening chronotype are often present in attention-deficit/hyperactivity disorder (ADHD). , considered…”
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Pharmacogenetic approach for a better drug treatment in children by Polanczyk, Guilherme, Bigarella, Marcelo P, Hutz, Mara H, Rohde, Luis Augusto

“…We conducted a systematic review of the literature aiming to identify original studies that have evaluated the effect of genes on the response to medications…”
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Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population by Friedrich, Deise C, Santos, Sidney E B, Ribeiro-dos-Santos, Ândrea K C, Hutz, Mara H

“…Adult-type hypolactasia is a common phenotype caused by the lactase enzyme deficiency. The -13910 C>T polymorphism, located 14 Kb upstream of the lactase gene…”
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Machine Learning for Prediction of Stable Warfarin Dose in US Latinos and Latin Americans by Steiner, Heidi E., Giles, Jason B., Patterson, Hayley Knight, Feng, Jianglin, El Rouby, Nihal, Claudio, Karla, Marcatto, Leiliane Rodrigues, Tavares, Leticia Camargo, Galvez, Jubby Marcela, Calderon-Ospina, Carlos-Alberto, Sun, Xiaoxiao, Hutz, Mara H., Scott, Stuart A., Cavallari, Larisa H., Fonseca-Mendoza, Dora Janeth, Duconge, Jorge, Botton, Mariana Rodrigues, Santos, Paulo Caleb Junior Lima, Karnes, Jason H.

“…Populations used to create warfarin dose prediction algorithms largely lacked participants reporting Hispanic or Latino ethnicity. While previous research…”
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The future of pharmacogenetics in Parkinson's disease treatment by Hutz, Mara H, Rieder, Carlos RM

“…The spectrum of clinical features and disease course manifested by individual patients varies greatly; some have an apparently benign disorder with a sustained…”
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Diagnostic prediction model for levodopa-induced dyskinesia in Parkinson’s disease by SANTOS-LOBATO, Bruno Lopes, SCHUMACHER-SCHUH, Artur F., RIEDER, Carlos R. M., HUTZ, Mara H., BORGES, Vanderci, FERRAZ, Henrique Ballalai, MATA, Ignacio F., ZABETIAN, Cyrus P., TUMAS, Vitor

“…Abstract Background: There are currently no methods to predict the development of levodopa-induced dyskinesia (LID), a frequent complication of Parkinson's…”
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IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil by Sortica, Vinicius A, Cunha, Maristela G, Ohnishi, Maria Deise O, Souza, Jose M, Ribeiro-Dos-Santos, Andrea K C, Santos, Ney P C, Callegari-Jacques, Sídia M, Santos, Sidney E B, Hutz, Mara H

“…Malaria is among the most prevalent parasitic diseases worldwide. In Brazil, malaria is concentrated in the northern region, where Plasmodium vivax accounts…”
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Association between DNA methyltransferase gene polymorphism and Parkinson’s disease by Pezzi, Julio Carlos, de Bem, Cintia Monique Boschmann Ens, da Rocha, Tatiane Jacobsen, Schumacher-Schuh, Artur F., Chaves, Marcia Lorena Fagundes, Rieder, Carlos Roberto, Hutz, Mara H., Fiegenbaum, Marilu, Camozzato, Ana Luiza

“…•This study first investigated the association among DNMT1 and DNMT3B polymorphisms with Parkinson Disease (PD) and showed an original result.•The DNMT3B…”
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