Search Results - "Hutton, Josiah E"

Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer by Hutton, Josiah E., Wang, Xiaojing, Zimmerman, Lisa J., Slebos, Robbert J.C., Trenary, Irina A., Young, Jamey D., Li, Ming, Liebler, Daniel C.

“…Metabolic reprogramming, in which altered utilization of glucose and glutamine supports rapid growth, is a hallmark of most cancers. Mutations in the oncogenes…”
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The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells by Melani, Rafael D, Gerbasi, Vincent R, Anderson, Lissa C, Sikora, Jacek W, Toby, Timothy K, Hutton, Josiah E, Butcher, David S, Negrão, Fernanda, Seckler, Henrique S, Srzentić, Kristina, Fornelli, Luca, Camarillo, Jeannie M, LeDuc, Richard D, Cesnik, Anthony J, Lundberg, Emma, Greer, Joseph B, Fellers, Ryan T, Robey, Matthew T, DeHart, Caroline J, Forte, Eleonora, Hendrickson, Christopher L, Abbatiello, Susan E, Thomas, Paul M, Kokaji, Andy I, Levitsky, Josh, Kelleher, Neil L

“…Human biology is tightly linked to proteins, yet most measurements do not precisely determine alternatively spliced sequences or posttranslational…”
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Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation by Shi, Wei, Sheng, Xinlei, Dorr, Kerry M., Hutton, Josiah E., Emerson, James I., Davies, Haley A., Andrade, Tia D., Wasson, Lauren K., Greco, Todd M., Hashimoto, Yutaka, Federspiel, Joel D., Robbe, Zachary L., Chen, Xuqi, Arnold, Arthur P., Cristea, Ileana M., Conlon, Frank L.

“…Sex disparities in cardiac homeostasis and heart disease are well documented, with differences attributed to actions of sex hormones. However, studies have…”
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Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk by Ntai, Ioanna, Fornelli, Luca, DeHart, Caroline J., Hutton, Josiah E., Doubleday, Peter F., LeDuc, Richard D., van Nispen, Alexandra J., Fellers, Ryan T., Whiteley, Gordon, Boja, Emily S., Rodriguez, Henry, Kelleher, Neil L.

“…Mutations of the KRAS gene are found in human cancers with high frequency and result in the constitutive activation of its protein products. This leads to…”
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Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair by Murray-Nerger, Laura A, Justice, Joshua L, Rekapalli, Pranav, Hutton, Josiah E, Cristea, Ileana M

“…Abstract The integrity and regulation of the nuclear lamina is essential for nuclear organization and chromatin stability, with its dysregulation being linked…”
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Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity by Justice, Joshua L, Kennedy, Michelle A, Hutton, Josiah E, Liu, Dawei, Song, Bokai, Phelan, Brett, Cristea, Ileana M

“…Dynamically shifting protein-protein interactions (PPIs) regulate cellular responses to viruses and the resulting immune signaling. Here, we use thermal…”
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Abstract B28: Multiplexed mass spectrometry analysis of KRAS-associated metabolic reprogramming in colorectal tumors and cell lines by Hutton, Josiah E., Zimmerman, Lisa J., Slebos, Robbert J., Li, Ming, Liebler, Daniel C.

“…Mutational activation of KRAS is associated with increased cellular proliferation and tumorigenicity, and metabolic reprogramming. We have used a mass…”
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