Search Results - "Huttner, Wieland"

Neural progenitors, neurogenesis and the evolution of the neocortex by Florio, Marta, Huttner, Wieland B

“…The neocortex is the seat of higher cognitive functions and, in evolutionary terms, is the youngest part of the mammalian brain. Since its origin, the…”
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Development and evolution of the primate neocortex from a progenitor cell perspective by Dehay, Colette, Huttner, Wieland B

“…The generation of neurons in the developing neocortex is a major determinant of neocortex size. Crucially, the increase in cortical neuron numbers in the…”
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Basal Progenitor Morphology and Neocortex Evolution by Kalebic, Nereo, Huttner, Wieland B.

“…The evolutionary expansion of the mammalian neocortex is widely considered to be a basis of increased cognitive abilities. This expansion is a consequence of…”
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Asymmetric Inheritance of Centrosome-Associated Primary Cilium Membrane Directs Ciliogenesis after Cell Division by Paridaen, Judith T.M.L., Wilsch-Bräuninger, Michaela, Huttner, Wieland B.

“…Primary cilia are key sensory organelles that are thought to be disassembled prior to mitosis. Inheritance of the mother centriole, which nucleates the primary…”
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The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex by Taverna, Elena, Götz, Magdalena, Huttner, Wieland B

“…Neural stem and progenitor cells have a central role in the development and evolution of the mammalian neocortex. In this review, we first provide a set of…”
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Neocortex expansion in development and evolution—from genes to progenitor cell biology by Pinson, Anneline, Huttner, Wieland B.

“…The evolutionary expansion of the neocortex, the seat of higher cognitive functions in humans, is primarily due to an increased and prolonged proliferation of…”
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Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset by Heide, Michael, Haffner, Christiane, Murayama, Ayako, Kurotaki, Yoko, Shinohara, Haruka, Okano, Hideyuki, Sasaki, Erika, Huttner, Wieland B.

“…Neocortex in the fetal brain Along the path of human evolution, gene duplication and divergence produced a protein, ARHGAP11B, that is found in humans but not…”
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How the extracellular matrix shapes neural development by Long, Katherine R, Huttner, Wieland B

“…During development, both cells and tissues must acquire the correct shape to allow their proper function. This is especially relevant in the nervous system,…”
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Metabolic Regulation of Neocortical Expansion in Development and Evolution by Namba, Takashi, Nardelli, Jeannette, Gressens, Pierre, Huttner, Wieland B.

“…The neocortex, the seat of our higher cognitive abilities, has expanded in size during the evolution of certain mammals such as primates, including humans…”
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What Makes Us Human: Insights from the Evolution and Development of the Human Neocortex by Namba, Takashi, Huttner, Wieland B

“…“What makes us human?” is a central question of many research fields, notably anthropology. In this review, we focus on the development of the human neocortex,…”
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An adaptive threshold in mammalian neocortical evolution by Lewitus, Eric, Kelava, Iva, Kalinka, Alex T, Tomancak, Pavel, Huttner, Wieland B

“…Expansion of the neocortex is a hallmark of human evolution. However, determining which adaptive mechanisms facilitated its expansion remains an open question…”
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Neural Progenitor Nuclei IN Motion by Taverna, Elena, Huttner, Wieland B.

“…Interkinetic nuclear migration (INM), the movement of neuroepithelial and radial glial cell nuclei along the apical-basal axis in concert with the cell cycle,…”
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Neurogenesis during development of the vertebrate central nervous system by Paridaen, Judith TML, Huttner, Wieland B

“…During vertebrate development, a wide variety of cell types and tissues emerge from a single fertilized oocyte. One of these tissues, the central nervous…”
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Human cerebral organoids recapitulate gene expression programs of fetal neocortex development by Camp, J. Gray, Badsha, Farhath, Florio, Marta, Kanton, Sabina, Gerber, Tobias, Wilsch-Bräuninger, Michaela, Lewitus, Eric, Sykes, Alex, Hevers, Wulf, Lancaster, Madeline, Knoblich, Juergen A., Lachmann, Robert, Pääbo, Svante, Huttner, Wieland B., Treutlein, Barbara

“…Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the…”
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Brain organoids as models to study human neocortex development and evolution by Heide, Michael, Huttner, Wieland B, Mora-Bermúdez, Felipe

“…Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer…”
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Cortical progenitor expansion, self-renewal and neurogenesis—a polarized perspective by Fietz, Simone A, Huttner, Wieland B

“…Neural stem and progenitor cells giving rise to neurons in developing mammalian neocortex fall into two principal classes with regard to location of…”
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Organoid single-cell genomic atlas uncovers human-specific features of brain development by Kanton, Sabina, Boyle, Michael James, He, Zhisong, Santel, Malgorzata, Weigert, Anne, Sanchís-Calleja, Fátima, Guijarro, Patricia, Sidow, Leila, Fleck, Jonas Simon, Han, Dingding, Qian, Zhengzong, Heide, Michael, Huttner, Wieland B., Khaitovich, Philipp, Pääbo, Svante, Treutlein, Barbara, Camp, J. Gray

“…The human brain has undergone substantial change since humans diverged from chimpanzees and the other great apes 1 , 2 . However, the genetic and developmental…”
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Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex by Long, Katherine R., Newland, Ben, Florio, Marta, Kalebic, Nereo, Langen, Barbara, Kolterer, Anna, Wimberger, Pauline, Huttner, Wieland B.

“…Neocortical expansion, thought to underlie the cognitive traits unique to humans, is accompanied by cortical folding. This folding starts around gestational…”
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Human-specific genomic signatures of neocortical expansion by Florio, Marta, Borrell, Víctor, Huttner, Wieland B

“…Highlights • Human-specific aspects of cortical expansion. • Genomic changes affecting cortical neurogenesis. • Human-specific genes affecting cortical…”
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Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders by Xing, Lei, Huttner, Wieland B., Namba, Takashi

“…Cell metabolism is a key regulator of human neocortex development and evolution. Several lines of evidence indicate that alterations in neural stem/progenitor…”
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