Search Results - "Hutter, Sébastien"

Structural simplification of the 3‐nitroimidazo[1,2‐ a ]pyridine antileishmanial pharmacophore: Design, synthesis, and antileishmanial activity of novel 2,4-disubstituted 5-nitroimidazoles by Paoli-Lombardo, Romain, Primas, Nicolas, Hutter, Sébastien, Castera-Ducros, Caroline, Jacquet, Inès, Verhaeghe, P., Azas, Nadine, Rathelot, Pascal, Vanelle, Patrice

“…As part of our ongoing antileishmanial structure–activity relationship study, a structural simplification of the 3‐nitroimidazo[1,2‐ a ]pyridine ring to a…”
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A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites by Bosson-Vanga, Henriette, Primas, Nicolas, Franetich, Jean-François, Lavazec, Catherine, Gomez, Lina, Ashraf, Kutub, Tefit, Maurel, Soulard, Valérie, Dereuddre-Bosquet, Nathalie, Le Grand, Roger, Donnette, Mélanie, Mustière, Romain, Amanzougaghene, Nadia, Tajeri, Shahin, Suzanne, Peggy, Malzert-Fréon, Aurélie, Rault, Sylvain, Vanelle, Patrice, Hutter, Sébastien, Cohen, Anita, Snounou, Georges, Roques, Pierre, Azas, Nadine, Lagardère, Prisca, Lisowski, Vincent, Masurier, Nicolas, Nguyen, Michel, Paloque, Lucie, Benoit-Vical, Françoise, Verhaeghe, Pierre, Mazier, Dominique

“…Human malaria infection begins with a one-time asymptomatic liver stage followed by a cyclic symptomatic blood stage. For decades, the research for novel…”
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Nongenotoxic 3‑Nitroimidazo[1,2‑a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity by Fersing, Cyril, Basmaciyan, Louise, Boudot, Clotilde, Pedron, Julien, Hutter, Sébastien, Cohen, Anita, Castera-Ducros, Caroline, Primas, Nicolas, Laget, Michèle, Casanova, Magali, Bourgeade-Delmas, Sandra, Piednoel, Mélanie, Sournia-Saquet, Alix, Belle Mbou, Valère, Courtioux, Bertrand, Boutet-Robinet, Élisa, Since, Marc, Milne, Rachel, Wyllie, Susan, Fairlamb, Alan H, Valentin, Alexis, Rathelot, Pascal, Verhaeghe, Pierre, Vanelle, Patrice, Azas, Nadine

“…Twenty nine original 3-nitroimidazo­[1,2-a]­pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized…”
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Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents – Part III by Ronga, Luisa, Del Favero, Marco, Cohen, Anita, Soum, Claire, Le Pape, Patrice, Savrimoutou, Solène, Pinaud, Noël, Mullié, Catherine, Daulouede, Sylvie, Vincendeau, Philippe, Farvacques, Natacha, Agnamey, Patrice, Pagniez, Fabrice, Hutter, Sébastien, Azas, Nadine, Sonnet, Pascal, Guillon, Jean

“…A series of new 4-alkapolyenylpyrrolo[1,2-a]quinoxaline derivatives, original and structural analogues of alkaloid chimanine B and of previously described…”
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Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate by Gendrot, Mathieu, Duflot, Isabelle, Boxberger, Manon, Delandre, Océane, Jardot, Priscilla, Le Bideau, Marion, Andreani, Julien, Fonta, Isabelle, Mosnier, Joel, Rolland, Clara, Hutter, Sébastien, La Scola, Bernard, Pradines, Bruno

“…At the end of November 2019, a novel coronavirus responsible for respiratory tract infections (COVID-19) emerged in China. Despite drastic containment…”
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In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2 by Gendrot, Mathieu, Andreani, Julien, Jardot, Priscilla, Hutter, Sébastien, Delandre, Océane, Boxberger, Manon, Mosnier, Joel, Le Bideau, Marion, Duflot, Isabelle, Fonta, Isabelle, Rolland, Clara, Bogreau, Hervé, La Scola, Bernard, Pradines, Bruno

“…In December 2019, a new severe acute respiratory syndrome coronavirus (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), emerged in Wuhan, China…”
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Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation by Gendrot, Mathieu, Andreani, Julien, Boxberger, Manon, Jardot, Priscilla, Fonta, Isabelle, Le Bideau, Marion, Duflot, Isabelle, Mosnier, Joel, Rolland, Clara, Bogreau, Hervé, Hutter, Sébastien, La Scola, Bernard, Pradines, Bruno

“…In December 2019, a new severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing coronavirus diseases 2019 (COVID-19) emerged in Wuhan, China…”
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Methylene blue inhibits replication of SARS-CoV-2 in vitro by Gendrot, Mathieu, Andreani, Julien, Duflot, Isabelle, Boxberger, Manon, Le Bideau, Marion, Mosnier, Joel, Jardot, Priscilla, Fonta, Isabelle, Rolland, Clara, Bogreau, Hervé, Hutter, Sébastien, La Scola, Bernard, Pradines, Bruno

“…•Methylene blue (MB) has a 50% cytotoxic concentration (CC50) >100 μM in Vero E6 cells.•MB inhibited SARS-CoV-2 replication in Vero E6 cells (EC50 = 0.30 ±…”
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Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines by Amrane, Dyhia, Gellis, Armand, Hutter, Sébastien, Prieri, Marion, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice, Primas, Nicolas

“…From three previously identified antiplasmodial hit compounds ( - ) and inactive series ( ), all based on a 2-trichloromethylquinazoline scaffold, we conducted…”
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Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices by Houël, Emeline, Ginouves, Marine, Azas, Nadine, Bourreau, Eliane, Eparvier, Véronique, Hutter, Sébastien, Knittel-Obrecht, Adeline, Jahn-Oyac, Arnaud, Prévot, Ghislaine, Villa, Pascal, Vonthron-Sénécheau, Catherine, Odonne, Guillaume

“…Leishmaniasis are widely distributed among tropical and subtropical countries, and remains a crucial health issue in Amazonia. Indigenous groups across…”
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Synthesis of Nitrostyrylthiazolidine-2,4-dione Derivatives Displaying Antileishmanial Potential by Khoumeri, Omar, Hutter, Sébastien, Primas, Nicolas, Castera-Ducros, Caroline, Carvalho, Sandra, Wyllie, Susan, Efrit, Mohamed Lotfi, Fayolle, Dimitri, Since, Marc, Vanelle, Patrice, Verhaeghe, Pierre, Azas, Nadine, El-Kashef, Hussein

“…A series of 61 thiazolidine-2,4-diones bearing a styryl group at position 5 was synthesized in 2-5 steps and their structure was proved by elemental and…”
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Looking for new antiplasmodial quinazolines: DMAP-catalyzed synthesis of 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines and their in vitro evaluation toward Plasmodium falciparum by Gellis, Armand, Primas, Nicolas, Hutter, Sébastien, Lanzada, Gilles, Remusat, Vincent, Verhaeghe, Pierre, Vanelle, Patrice, Azas, Nadine

“…A DMAP catalyzed synthesis of new 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines was studied, in a view to react 4-chloroquinazolines with poorly…”
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Pd-catalyzed C-C and C-N cross-coupling reactions in 2-aminothieno[3,2-]pyrimidin-4(3)-one series for antiplasmodial pharmacomodulation by Mustière, Romain, Lagardère, Prisca, Hutter, Sébastien, Deraeve, Céline, Schwalen, Florian, Amrane, Dyhia, Masurier, Nicolas, Azas, Nadine, Lisowski, Vincent, Verhaeghe, Pierre, Mazier, Dominique, Vanelle, Patrice, Primas, Nicolas

“…In 2015, we identified gamhepathiopine (M1), a 2- tert -butylaminothieno[3,2- d ]pyrimidin-4(3 H )-one antiplasmodial hit targeting all development stages of…”
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New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability by Lagardère, Prisca, Mustière, Romain, Amanzougaghene, Nadia, Hutter, Sébastien, Casanova, Marion, Franetich, Jean-François, Tajeri, Shahin, Malzert-Fréon, Aurélie, Corvaisier, Sophie, Azas, Nadine, Vanelle, Patrice, Verhaeghe, Pierre, Primas, Nicolas, Mazier, Dominique, Masurier, Nicolas, Lisowski, Vincent

“…The increasing number of Plasmodium falciparum strains resistant to current treatments justifies the urgent need to discover new compounds active on several…”
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4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives by Lagardère, Prisca, Mustière, Romain, Amanzougaghene, Nadia, Hutter, Sébastien, Franetich, Jean-François, Azas, Nadine, Vanelle, Patrice, Verhaeghe, Pierre, Primas, Nicolas, Mazier, Dominique, Masurier, Nicolas, Lisowski, Vincent

“…Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of…”
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Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold by Desroches, Justine, Kieffer, Charline, Primas, Nicolas, Hutter, Sébastien, Gellis, Armand, El-Kashef, Hussein, Rathelot, Pascal, Verhaeghe, Pierre, Azas, Nadine, Vanelle, Patrice

“…From 4 antiplasmodial hit-molecules identified in 2-trichloromethylquinazoline series, we conducted a global Structure-Activity relationship (SAR) study…”
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Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability by Lagardère, Prisca, Mustière, Romain, Amanzougaghene, Nadia, Hutter, Sébastien, Casanova, Marion, Franetich, Jean-François, Tajeri, Shahin, Malzert-Fréon, Aurélie, Corvaisier, Sophie, Since, Marc, Azas, Nadine, Vanelle, Patrice, Verhaeghe, Pierre, Primas, Nicolas, Mazier, Dominique, Masurier, Nicolas, Lisowski, Vincent

“…Based on the structure of a previously identified hit, Gamhepathiopine 1, which showed promising antiplasmodial activity, but poor microsomal stability,…”
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Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy by Mustière, Romain, Lagardère, Prisca, Hutter, Sébastien, Dell’Orco, Viviana, Amanzougaghene, Nadia, Tajeri, Shahin, Franetich, Jean-François, Corvaisier, Sophie, Since, Marc, Malzert-Fréon, Aurélie, Masurier, Nicolas, Lisowski, Vincent, Verhaeghe, Pierre, Mazier, Dominique, Azas, Nadine, Vanelle, Patrice, Primas, Nicolas

“…Gamhepathiopine (also known as M1), is a multi-stage acting antiplasmodial 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hydrochloride that was first…”
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Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants by Delandre, Océane, Gendrot, Mathieu, Jardot, Priscilla, Le Bideau, Marion, Boxberger, Manon, Boschi, Céline, Fonta, Isabelle, Mosnier, Joel, Hutter, Sébastien, Levasseur, Anthony, La Scola, Bernard, Pradines, Bruno

“…Over the past two years, several variants of SARS-CoV-2 have emerged and spread all over the world. However, infectivity, clinical severity, re-infection,…”
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Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines by Verhaeghe, Pierre, Azas, Nadine, Gasquet, Monique, Hutter, Sébastien, Ducros, Christophe, Laget, Michèle, Rault, Sylvain, Rathelot, Pascal, Vanelle, Patrice

“…A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling…”
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