Search Results - "Hutter, Michael C"

Highly regio- and stereoselective hydroxylation of vitamin D2 by CYP109E1 by Putkaradze, Natalia, König, Lisa, Kattner, Lars, Hutter, Michael C., Bernhardt, Rita

“…Vitamin D2 is a form of vitamin D derived from mushrooms and plants which is structurally modified in the body due to the action of several enzymes. The…”
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Spotlight on CYP4B1 by Röder, Annika, Hüsken, Saskia, Hutter, Michael C, Rettie, Allan E, Hanenberg, Helmut, Wiek, Constanze, Girhard, Marco

“…The mammalian cytochrome P450 monooxygenase CYP4B1 can bioactivate a wide range of xenobiotics, such as its defining/hallmark substrate 4-ipomeanol leading to…”
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Differential Multimolecule Fingerprint for Similarity SearchMaking Use of Active and Inactive Compound Sets in Virtual Screening by Hutter, Michael C.

“…In conventional fingerprint methods, the similarity between two molecules is calculated using the Tanimoto index as a numerical criterion. Thus, the query…”
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Regioselective hydroxylation of norisoprenoids by CYP109D1 from Sorangium cellulosum So ce56 by Khatri, Yogan, Girhard, Marco, Romankiewicz, Anna, Ringle, Michael, Hannemann, Frank, Urlacher, Vlada B, Hutter, Michael C, Bernhardt, Rita

“…Sesquiterpenes are particularly interesting as flavorings and fragrances or as pharmaceuticals. Regio- or stereoselective functionalizations of terpenes are…”
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Human aldosterone synthase: Recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level by Hobler, Anna, Kagawa, Norio, Hutter, Michael C., Hartmann, Michaela F., Wudy, Stefan A., Hannemann, Frank, Bernhardt, Rita

“…► First successful expression in E. coli and purification of human aldosterone synthase. ► Very weak binding of the first reaction intermediate compared to the…”
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The current limits in virtual screening and property prediction by Hutter, Michael C

“…Beyond finding inhibitors that show high binding affinity to the respective target, there is the challenge of optimizing their properties with respect to…”
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Photolytic Cleavage of 1-(2-Nitrophenyl)ethyl Ethers Involves Two Parallel Pathways and Product Release Is Rate-Limited by Decomposition of a Common Hemiacetal Intermediate by Corrie, John E. T, Barth, Andreas, Munasinghe, V. Ranjit N, Trentham, David R, Hutter, Michael C

“…Time-resolved FTIR spectroscopic studies of the flash photolysis of several 1-(2-nitrophenyl)ethyl ethers derived from aliphatic alcohols showed that a…”
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Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine by Bokel, Ansgar, Hutter, Michael C, Urlacher, Vlada B

“…Saturation mutagenesis at seven first-sphere residues of the cytochrome P450 monooxygenase 154E1 (CYP154E1) from Thermobifida fusca YX was applied to construct…”
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Dynamic Water Networks in Cytochrome c Oxidase from Paracoccus denitrificans Investigated by Molecular Dynamics Simulations by Olkhova, Elena, Hutter, Michael C., Lill, Markus A., Helms, Volkhard, Michel, Hartmut

“…We present a molecular dynamics study of cytochrome c oxidase from Paracoccus denitrificans in the fully oxidized state, embedded in a fully hydrated…”
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Conservation and Relevance of Pharmacophore Point Types by Fehlmann, Tobias, Hutter, Michael C

“…Pharmacophore models in general use a variety of features for distinct chemical characteristics, such as hydrogen-bond properties, lipohilicity, and…”
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Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1 by Putkaradze, Natalia, Hartz, Philip, Hutter, Michael C., Zapp, Josef, Thevis, Mario, Bernhardt, Rita

“…•The activity of the major human brain cytochrome P450, CYP46A1 towards AAS was investigated.•Oral turinabol (dehydrochloromethyltestosterone) is metabolized…”
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Novel approach to improve progesterone hydroxylation selectivity by CYP106A2 via rational design of adrenodoxin binding by Sagadin, Tanja, Riehm, Jan, Putkaradze, Natalia, Hutter, Michael C., Bernhardt, Rita

“…Bacterial P450s have considerable potential for biotechnological applications. The P450 CYP106A2 from Bacillus megaterium ATCC 13368 converts progesterone to…”
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Enzyme-Mediated Two-Step Regio- and Stereoselective Synthesis of Potential Rapid-Acting Antidepressant (2S,6S)‑Hydroxynorketamine by Bokel, Ansgar, Rühlmann, Ansgar, Hutter, Michael C, Urlacher, Vlada B

“…Recently, the anesthetic (S)-ketamine has been approved as a rapid-acting and long-lasting antidepressant. Its metabolite, (2S,6S)-hydroxynorketamine, has been…”
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Novel insights into oxidation of fatty acids and fatty alcohols by cytochrome P450 monooxygenase CYP4B1 by Thesseling, Florian A., Hutter, Michael C., Wiek, Constanze, Kowalski, John P., Rettie, Allan E., Girhard, Marco

“…CYP4B1 is an enigmatic mammalian cytochrome P450 monooxygenase acting at the interface between xenobiotic and endobiotic metabolism. A prominent CYP4B1…”
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New CYP154C4 from Streptomyces cavourensis YBQ59 performs regio- and stereo- selective 3β-hydroxlation of nootkatone by Ly, Thuy T.B., Thi Mai, Thu-Thuy, Raffaele, Alessandra, Urlacher, Vlada B., Nguyen, Thi Thao, Hutter, Michael C., Thi Vu, Hanh-Nguyen, Thuy Le, Duong Thi, Quach, Tung Ngoc, Phi, Quyet-Tien

“…Nootkatone, a sesquiterpenoid widely used in the food and cosmetics industries, exhibits diverse biological activities and pharmaceutical prospects…”
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Resurrection and characterization of ancestral CYP11A1 enzymes by Hartz, Philip, Strohmaier, Silja J., EL‐Gayar, Basma M., Abdulmughni, Ammar, Hutter, Michael C., Hannemann, Frank, Gillam, Elizabeth M. J., Bernhardt, Rita

“…Mitochondrial cytochromes P450 presumably originated from a common microsomal P450 ancestor. However, it is still unknown how ancient mitochondrial P450s were…”
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Engineering of versatile redox partner fusions that support monooxygenase activity of functionally diverse cytochrome P450s by Bakkes, Patrick J., Riehm, Jan L., Sagadin, Tanja, Rühlmann, Ansgar, Schubert, Peter, Biemann, Stefan, Girhard, Marco, Hutter, Michael C., Bernhardt, Rita, Urlacher, Vlada B.

“…Most bacterial cytochrome P450 monooxygenases (P450s or CYPs) require two redox partner proteins for activity. To reduce complexity of the redox chain, the…”
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Biotransformation of prednisone and dexamethasone by cytochrome P450 based systems – Identification of new potential drug candidates by Putkaradze, Natalia, Kiss, Flora Marta, Schmitz, Daniela, Zapp, Josef, Hutter, Michael C., Bernhardt, Rita

“…•The ability of CYP106A2 to hydroxylate prednisone and dexamethasone at position 15β is described.•The in vitro conversion of prednisone and dexamethasone with…”
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Regioselective Acetylation of C21 Hydroxysteroids by the Bacterial Chloramphenicol Acetyltransferase I by Mosa, Azzam, Hutter, Michael C., Zapp, Josef, Bernhardt, Rita, Hannemann, Frank

“…Chloramphenicol acetyltransferase I (CATI) detoxifies the antibiotic chloramphenicol and confers a corresponding resistance to bacteria. In this study we…”
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Identification and circumvention of bottlenecks in CYP21A2‐mediated premedrol production using recombinant Escherichia coli by König, Lisa, Brixius‐Anderko, Simone, Milhim, Mohammed, Tavouli‐Abbas, Daniela, Hutter, Michael C., Hannemann, Frank, Bernhardt, Rita

“…Synthetic glucocorticoids such as methylprednisolone are compounds of fundamental interest to the pharmaceutical industry as their modifications within the…”
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