Search Results - "Hutter, Lukas H"
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A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit
Published in The Journal of cell biology (29-08-2016)“…PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are…”
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CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization
Published in The Journal of cell biology (01-04-2019)“…Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a…”
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Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback
Published in Cell reports (Cambridge) (20-10-2015)“…Sister chromatid cohesion, mediated by the cohesin complex, is essential for faithful mitosis. Nevertheless, evidence suggests that the surveillance mechanism…”
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Interlinked bistable mechanisms generate robust mitotic transitions
Published in Cell cycle (Georgetown, Tex.) (18-10-2017)“…The transitions between phases of the cell cycle have evolved to be robust and switch-like, which ensures temporal separation of DNA replication, sister…”
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CORALINA: a universal method for the generation of gRNA libraries for CRISPR-based screening
Published in BMC genomics (14-11-2016)“…The bacterial CRISPR system is fast becoming the most popular genetic and epigenetic engineering tool due to its universal applicability and adaptability. The…”
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