Search Results - "Hutter, B"

Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling by Kordes, M, Röring, M, Heining, C, Braun, S, Hutter, B, Richter, D, Geörg, C, Scholl, C, Gröschel, S, Roth, W, Rosenwald, A, Geissinger, E, von Kalle, C, Jäger, D, Brors, B, Weichert, W, Grüllich, C, Glimm, H, Brummer, T, Fröhling, S

“…Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations…”
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High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma by Westphal, D., Garzarolli, M., Sergon, M., Horak, P., Hutter, B., Becker, J.C., Wiegel, M., Maczey, E., Blum, S., Grosche‐Schlee, S., Rütten, A., Ugurel, S., Stenzinger, A., Glimm, H., Aust, D., Baretton, G., Beissert, S., Fröhling, S., Redler, S., Surowy, H., Meier, F.

“…Summary Background Eccrine porocarcinoma (EPC) is a rare skin cancer arising from the eccrine sweat glands. Due to the lack of effective therapies, metastasis…”
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Quantitative evaluation of orofacial motor function in mice: The pasta gnawing test, a voluntary and stress-free behavior test by Rabl, R., Horvath, A., Breitschaedel, C., Flunkert, S., Roemer, H., Hutter-Paier, B.

“…•The pasta gnawing test measures orofacial motor deficits.•The pasta gnawing test is useful as an alternative to limb motor tests.•The pasta gnawing test is…”
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CHF5074, a novel γ‐secretase modulator, attenuates brain β‐amyloid pathology and learning deficit in a mouse model of Alzheimer's disease by Imbimbo, BP, Hutter‐Paier, B, Villetti, G, Facchinetti, F, Cenacchi, V, Volta, R, Lanzillotta, A, Pizzi, M, Windisch, M

“…Background and purpose:  We evaluated the effects of 1‐(3′,4′‐dichloro‐2‐fluoro[1,1′‐biphenyl]‐4‐yl)‐cyclopropanecarboxylic acid (CHF5074), a new γ‐secretase…”
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Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma by Dieter, S.M., Heining, C., Agaimy, A., Huebschmann, D., Bonekamp, D., Hutter, B., Ehrenberg, K.R., Fröhlich, M., Schlesner, M., Scholl, C., Schlemmer, H.-P., Wolf, S., Mavratzas, A., Jung, C.S., Gröschel, S., von Kalle, C., Eils, R., Brors, B., Penzel, R., Kriegsmann, M., Reuss, D.E., Schirmacher, P., Stenzinger, A., Federspil, P.A., Weichert, W., Glimm, H., Fröhling, S.

“…Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet…”
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Prospective genome and transcriptome sequencing in advanced-stage neuroendocrine neoplasms by Apostolidis, L., Kreutzfeldt, S., Oles, M., Gieldon, L., Heining, C., Horak, P., Hutter, B., Fröhlich, M., Klink, B., Lamping, M., Uhrig, S., Stenzinger, A., Winkler, E.C., Wiedenmann, B., Jäger, D., Schröck, E., Keilholz, U., Pavel, M.E., Glimm, H., Fröhling, S.

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PO-400 Arriba – fast and accurate gene fusion detection from RNA-seq data by Uhrig, S, Fröhlich, M, Hutter, B, Brors, B

“…IntroductionPersonalised oncology revolutionises the way how eligible therapies are selected to treat cancer patients. With the help of next-generation…”
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Repetitive elements in imprinted genes by Walter, J, Hutter, B, Khare, T, Paulsen, M

“…Genomic imprinting in mammals results in mono-allelic expression of about 80 genes depending on the parental origin of the alleles. Though the epigenetic…”
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431: Identification of deregulated genes in colorectal cancer metastasis through whole genome and transcriptome sequencing by Hauser, C, Hutter, B, Buchhalter, I, Shavinskaya, A, Abba, M, Yazdanparast, H, Eils, R, Brors, B, Allgayer, H

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Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial by Heilig, C.E., Horak, P., Kreutzfeldt, S., Teleanu, V., Mock, A., Renner, M., Bhatti, I.A., Hutter, B., Hüllein, J., Fröhlich, M., Uhrig, S., Süße, H., Heiligenthal, L., Ochsenreither, S., Illert, A.L., Vogel, A., Desuki, A., Heinemann, V., Heidegger, S., Bitzer, M., Scheytt, M., Brors, B., Hübschmann, D., Baretton, G., Stenzinger, A., Steindorf, K., Benner, A., Jäger, D., Heining, C., Glimm, H., Fröhling, S., Schlenk, R.F.

“…Approvals of cancer therapeutics are primarily disease entity specific. Current molecular diagnostic approaches frequently identify actionable alterations in…”
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CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice by Unger, M.S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T.M., Heneka, M.T., Attems, J., Aigner, L.

“…•CD8+ T-cells infiltrate the brain in aging and human AD pathology.•CD8+ T-cells can successfully be ablated from blood and brain using an anti-CD8 antibody…”
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PO-451 Targeted proteomics to improve therapy stratification of cancer patients by Wiemann, S, Wahjudi, L, Bernhardt, S, Abnaof, K, Richter, D, Hutter, B, Kreutzfeldt, S, Heining, C, Horak, P, Fröhling, S

“…IntroductionThe heterogeneity of tumours calls for patient stratification to select the most effective, personalised therapies. The NCT MASTER (Molecularly…”
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Effects of cerebrolysin on the outgrowth and protection of processes of cultured brain neurons by HARTBAUER, M, HUTTER-PAIER, B, WINDISCH, M

“…Cerebrolysin (Cere, EBEWE Arzneimittel, Austria), a peptidergic drug produced by a standardised enzymatic breakdown of porcine brain proteins, consists of a…”
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Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice by Rabl, R, Breitschaedel, C, Flunkert, S, Duller, S, Amschl, D, Neddens, J, Niederkofler, V, Rockenstein, E, Masliah, E, Roemer, H, Hutter-Paier, B

“…Synucleinopathies such as Parkinson's disease or multiple system atrophy are characterized by Lewy bodies in distinct brain areas. These aggregates are mainly…”
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Is alpha-synuclein pathology a target for treatment of neurodegenerative disorders? by Windisch, M, Wolf, H J, Hutter-Paier, B, Hofmeister, A, Wronski, R

“…Alpha-synuclein is the main constituent of intra-neuronal Lewy bodies, which are characteristic of Parkinson's disease, but aggregates are also found as axonal…”
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SEN1500, a novel oral amyloid-β aggregation inhibitor, attenuates brain pathology in a mouse model of Alzheimer’s disease by Brunner, D., Flunkert, S., Neddens, J., Duller, S., Scopes, D.I.C., Treherne, J.M., Hutter-Paier, B.

“…•SEN1500 reduces insoluble aggregated brain amyloid in APPSL mice.•SEN1500 reduces activated microglia in the cortex of APPSL mice.•SEN1500 is a novel…”
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomes by Rheinbay, Esther, Nielsen, Morten Muhlig, Abascal, Federico, Wala, Jeremiah A., Shapira, Ofer, Tiao, Grace, Hornshøj, Henrik, Hess, Julian M., Juul, Randi Istrup, Lin, Ziao, Feuerbach, Lars, Sabarinathan, Radhakrishnan, Madsen, Tobias, Kim, Jaegil, Mularoni, Loris, Shuai, Shimin, Lanzós, Andrés, Herrmann, Carl, Maruvka, Yosef E., Shen, Ciyue, Amin, Samirkumar B., Bandopadhayay, Pratiti, Bertl, Johanna, Boroevich, Keith A., Busanovich, John, Carlevaro-Fita, Joana, Chakravarty, Dimple, Chan, Calvin Wing Yiu, Craft, David, Dhingra, Priyanka, Diamanti, Klev, Fonseca, Nuno A., Gonzalez-Perez, Abel, Guo, Qianyun, Hamilton, Mark P., Haradhvala, Nicholas J., Hong, Chen, Isaev, Keren, Johnson, Todd A., Juul, Malene, Kahles, Andre, Kahraman, Abdullah, Kim, Youngwook, Komorowski, Jan, Kumar, Kiran, Kumar, Sushant, Lee, Donghoon, Lehmann, Kjong-Van, Li, Yilong, Liu, Eric Minwei, Lochovsky, Lucas, Park, Keunchil, Pich, Oriol, Roberts, Nicola D., Saksena, Gordon, Schumacher, Steven E., Sidiropoulos, Nikos, Sieverling, Lina, Sinnott-Armstrong, Nasa, Stewart, Chip, Tamborero, David, Tubio, Jose M. C., Umer, Husen M., Uusküla-Reimand, Liis, Wadelius, Claes, Wadi, Lina, Yao, Xiaotong, Zhang, Cheng-Zhong, Zhang, Jing, Haber, James E., Hobolth, Asger, Imielinski, Marcin, Kellis, Manolis, Lawrence, Michael S., von Mering, Christian, Nakagawa, Hidewaki, Raphael, Benjamin J., Rubin, Mark A., Sander, Chris, Stein, Lincoln D., Stuart, Joshua M., Tsunoda, Tatsuhiko, Wheeler, David A., Johnson, Rory, Reimand, Jüri, Gerstein, Mark, Khurana, Ekta, Campbell, Peter J., López-Bigas, Núria, Weischenfeldt, Joachim, Beroukhim, Rameen, Martincorena, Iñigo, Pedersen, Jakob Skou, Getz, Gad

“…The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 – 4 . Here we present analyses of driver point mutations and structural…”
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Prognostic factors for patients with microsurgically resected brain metastases by Korinth, M C, Delonge, C, Hütter, B O, Gilsbach, J M

“…With the advent of new therapies for metastatic carcinoma to the brain, patterns of intracranial disease and factors influencing survival become important…”
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Course of brain shift during microsurgical resection of supratentorial cerebral lesions: limits of conventional neuronavigation by Reinges, M H T, Nguyen, H-H, Krings, T, Hütter, B-O, Rohde, V, Gilsbach, J M

“…The authors have conducted a prospective study to evaluate the amount and course of brain shift during microsurgical removal of supratentorial cerebral…”
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When actions have consequences: empirically based decision making for intelligent user interfaces by Jameson, A, Grossmann-Hutter, B, March, L, Rummer, R, Bohnenberger, T, Wittig, F

“…One feature of intelligent user interfaces is an ability to make decisions that take into account a variety of factors, some of which may depend on the current…”
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