Search Results - "Hutson, Susan M."

Branched-Chain Amino Acids and Brain Metabolism by Sperringer, Justin E., Addington, Adele, Hutson, Susan M.

“…This review aims to provide a historical reference of branched-chain amino acid (BCAA) metabolism and provide a link between peripheral and central nervous…”
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FGF21 is an endocrine signal of protein restriction by Laeger, Thomas, Henagan, Tara M, Albarado, Diana C, Redman, Leanne M, Bray, George A, Noland, Robert C, Münzberg, Heike, Hutson, Susan M, Gettys, Thomas W, Schwartz, Michael W, Morrison, Christopher D

“…Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. Here, we demonstrated that…”
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BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 by Tönjes, Martje, Barbus, Sebastian, Park, Yoon Jung, Wang, Wei, Schlotter, Magdalena, Lindroth, Anders M, Pleier, Sabrina V, Bai, Alfa H C, Karra, Daniela, Piro, Rosario M, Felsberg, Jörg, Addington, Adele, Lemke, Dieter, Weibrecht, Irene, Hovestadt, Volker, Rolli, Claudio G, Campos, Benito, Turcan, Sevin, Sturm, Dominik, Witt, Hendrik, Chan, Timothy A, Herold-Mende, Christel, Kemkemer, Ralf, König, Rainer, Schmidt, Kathrin, Hull, William-Edmund, Pfister, Stefan M, Jugold, Manfred, Hutson, Susan M, Plass, Christoph, Okun, Jürgen G, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard

“…Branched-chain amino acid transaminase 1, the enzyme that initiates the catabolism of branched-chain amino acids, is involved in glioma pathogenesis, making it…”
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Functional impact of high protein intake on healthy elderly people by Walrand, Stephane, Short, Kevin R, Bigelow, Maureen L, Sweatt, Andrew J, Hutson, Susan M, Nair, K Sreekumaran

“…Decline in muscle mass, protein synthesis, and mitochondrial function occurs with age, and amino acids are reported to enhance both muscle protein synthesis…”
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Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase by Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Wallace, Amy L., Ahmed, Kamran, Laxman, Sunil, Campeau, Philippe M., Lee, Brendan H., Hutson, Susan M., Tu, Benjamin P., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.

“…The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine disease, heart failure, obesity, and type 2 diabetes…”
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Leucine in food mediates some of the postprandial rise in plasma leptin concentrations by Lynch, Christopher J, Gern, Beth, Lloyd, Carolyn, Hutson, Susan M, Eicher, Rachel, Vary, Thomas C

“…In vitro, leptin secretion is regulated at the level of mRNA translation by the rapamycin-sensitive mammalian target of rapamycin (mTOR) and its agonist…”
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Mex3c Mutation Reduces Adiposity and Increases Energy Expenditure by Jiao, Yan, George, Sunil K., Zhao, Qingguo, Hulver, Matthew W., Hutson, Susan M., Bishop, Colin E., Lu, Baisong

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The case for regulating indispensable amino acid metabolism: the branched-chain alpha-keto acid dehydrogenase kinase-knockout mouse by Hutson, Susan M

“…BCAAs (branched-chain amino acids) are indispensable (essential) amino acids that are required for body protein synthesis. Indispensable amino acids cannot be…”
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Expression of mitochondrial branched-chain aminotransferase and α-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism by Cole, Jeffrey T, Sweatt, Andrew J, Hutson, Susan M

“…In the brain, metabolism of the essential branched chain amino acids (BCAAs) leucine, isoleucine, and valine, is regulated in part by protein synthesis…”
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Widespread neuronal expression of branched‐chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids by García‐Espinosa, María A., Wallin, Reidar, Hutson, Susan M., Sweatt, Andrew J.

“…Transamination of the branched‐chain amino acids produces glutamate and branched‐chain α‐ketoacids. The reaction is catalyzed by branched‐chain…”
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Increased Production of Functional Recombinant Human Clotting Factor IX by Baby Hamster Kidney Cells Engineered to Overexpress VKORC1, the Vitamin K 2,3-Epoxide-reducing Enzyme of the Vitamin K Cycle by Wajih, Nadeem, Hutson, Susan M., Owen, John, Wallin, Reidar

“…Some recombinant vitamin K-dependent blood coagulation factors (factors VII, IX, and protein C) have become valuable pharmaceuticals in the treatment of…”
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Structural Determinants for Branched-chain Aminotransferase Isozyme-specific Inhibition by the Anticonvulsant Drug Gabapentin by Goto, Masaru, Miyahara, Ikuko, Hirotsu, Ken, Conway, Myra, Yennawar, Neela, Islam, Mohammad M., Hutson, Susan M.

“…This study presents the first three-dimensional structures of human cytosolic branched-chain aminotransferase (hBCATc) isozyme complexed with the neuroactive…”
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Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR by Lynch, Christopher J, Halle, Beth, Fujii, Hisao, Vary, Thomas C, Wallin, Reidar, Damuni, Zahi, Hutson, Susan M

“…Leucine has been shown to stimulate adipose tissue protein synthesis in vivo as well as leptin secretion, protein synthesis, hyper-plastic growth, and tissue…”
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Function of leucine in excitatory neurotransmitter metabolism in the central nervous system by Hutson, S M, Lieth, E, LaNoue, K F

“…A novel hypothesis for the role of branched-chain amino acids (BCAA) in regulating levels of the major excitatory neurotransmitter glutamate in the central…”
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Leucine Metabolism in T Cell Activation: mTOR Signaling and Beyond by Ananieva, Elitsa A, Powell, Jonathan D, Hutson, Susan M

“…In connection with the increasing interest in metabolic regulation of the immune response, this review discusses current advances in understanding the role of…”
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Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system by Nautiyal, Manisha, Sweatt, Andrew J., MacKenzie, James A., Mark Payne, R., Szucs, Sylvia, Matalon, Reuben, Wallin, Reidar, Hutson, Susan M.

“…The NIPSNAP (4‐nitrophenylphosphatase domain and non‐neuronal SNAP25‐like protein homolog 1) proteins belong to a highly conserved family of proteins of…”
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Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats by Lynch, Christopher J, Hutson, Susan M, Patson, Brian J, Vaval, Alain, Vary, Thomas C

“…Acute administration of leucine and norleucine activates the mammalian target of rapamycin (mTOR) cell-signaling pathway and increases rates of protein…”
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Nitrogen shuttling between neurons and glial cells during glutamate synthesis by Lieth, Erich, LaNoue, Kathryn F., Berkich, Deborah A., Xu, Baiyang, Ratz, Michael, Taylor, Charles, Hutson, Susan M.

“…The relationship between neuronal glutamate turnover, the glutamate/glutamine cycle and de novo glutamate synthesis was examined using two different model…”
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Branched-chain amino acids and neurotransmitter metabolism: Expression of cytosolic branched-chain aminotransferase (BCATc) in the cerebellum and hippocampus by Sweatt, Andrew J., Garcia-Espinosa, Maria A., Wallin, Reidar, Hutson, Susan M.

“…In the brain, catabolism of the branched‐chain amino acids (BCAAs) provides nitrogen for the synthesis of glutamate and glutamine. Glutamate is formed through…”
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Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism by She, Pengxiang, Van Horn, Cynthia, Reid, Tanya, Hutson, Susan M, Cooney, Robert N, Lynch, Christopher J

“…Elevations in branched-chain amino acids (BCAAs) in human obesity were first reported in the 1960s. Such reports are of interest because of the emerging role…”
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